The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L.

  • Kim, Wan-Su (Department of Periodontology, College of Dentistry, Wonkwang University) ;
  • Choi, Woo Jin (Department of Microbiology, College of Medicine, Chung-Ang University) ;
  • Lee, Sunwoo (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Kim, Woo Joong (Department of Microbiology, College of Medicine, Chung-Ang University) ;
  • Lee, Dong Chae (Department of Microbiology, College of Medicine, Chung-Ang University) ;
  • Sohn, Uy Dong (Asia Pacific International School) ;
  • Shin, Hyoung-Shik (Department of Periodontology, College of Dentistry, Wonkwang University) ;
  • Kim, Wonyong (Department of Microbiology, College of Medicine, Chung-Ang University)
  • Received : 2014.08.12
  • Accepted : 2014.10.15
  • Published : 2015.01.30
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Abstract

The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin-containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), and proinflammatory cytokine ($IL-1{\beta}$, IL-6, and IL-10) production. Antioxidant activity evaluations revealed that the ethanol extract had the highest free radical scavenging activity, ($91.0{\pm}3.2%$), similar to ${\alpha}$-tocopherol (99.9%). The extracts had antimicrobial activity against the periodontopathic microorganisms Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum subsp. animalis, Fusobacterium nucleatum subsp. polymorphum, and Prevotella intermedia. This study shows that Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.

Keywords

References

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