Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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High Hydrostatic Pressure Extract of Red Ginseng Attenuates Inflammation in Rats with High-fat Diet Induced Obesity

  • Jung, Sunyoon (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Lee, Mak-Soon (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Shin, Yoonjin (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Kim, Chong-Tai (Functional Materials Research Group, Korea Food Research Institute) ;
  • Kim, In-Hwan (Department of Food and Nutrition, Korea University) ;
  • Kim, Yangha (Department of Nutritional Science and Food Management, Ewha Womans University)
  • Received : 2015.07.02
  • Accepted : 2015.09.25
  • Published : 2015.12.31
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Abstract

Chronic low-grade inflammation is associated with obesity. This study investigated effect of high hydrostatic pressure extract of red ginseng (HRG) on inflammation in rats with high-fat (HF) diet induced obesity. Male, Sprague-Dawley rats (80~110 g) were randomly divided into two groups, and fed a 45% HF diet (HF) and a 45% HF diet containing 1.5% HRG (HF+HRG) for 14 weeks. At the end of the experiment, the serum leptin level was reduced by the HRG supplementation. The mRNA expression of genes related to adipogenesis including peroxisome proliferator-activated receptor-gamma and adipocyte protein 2 was down-regulated in the white adipose tissue (WAT). The mRNA levels of major inflammatory cytokines such as tumor necrosis factor-${\alpha}$, monocyte chemoattractant protein 1, and interleukin-6 were remarkably down-regulated by the HRG in WAT. These results suggest that HRG might be beneficial in ameliorating the inflammation-associated health complications by suppressing adipogenic and pro-inflammatory gene expression.

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References

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