Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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Human Papillomavirus Prevalence and Distribution according to Age among Korean and Chinese Women

중국과 한국여성에서 나이에 따른 인유두종바이러스의 유병률과 분포

  • Kim, Geehyuk (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University) ;
  • Kim, Sunghyun (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Park, Sunyoung (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University) ;
  • Park, Sangjung (Department of Clinical Laboratory Science, College of Medical Science, Daegu Haany University) ;
  • Lin, Han (Department of Pathology, Liaocheng School of Clinical Medicine, Taishan Medical University) ;
  • Ren, Yubo (Department of Pathology, Liaocheng School of Clinical Medicine, Taishan Medical University) ;
  • Li, Yingxue (Department of Pathology, Liaocheng School of Clinical Medicine, Taishan Medical University) ;
  • Lee, In Soo (Department of Clinical Laboratory Science, Hyejeon College) ;
  • Lee, Jae Dal (Department of Clinical Laboratory Science, Hyejeon College) ;
  • Lee, Dongsup (Department of Clinical Laboratory Science, Hyejeon College)
  • 김지혁 (연세대학교 임상병리학과) ;
  • 김성현 (부산카톨릭대학교 임상병리학과) ;
  • 박선영 (연세대학교 임상병리학과) ;
  • 박상정 (대구한의과대학 임상병리학과) ;
  • ;
  • ;
  • ;
  • 이인수 (혜전대학교 임상병리과) ;
  • 이재달 (혜전대학교 임상병리과) ;
  • 이동섭 (혜전대학교 임상병리과)
  • Received : 2015.10.08
  • Accepted : 2015.11.09
  • Published : 2015.12.30
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Abstract

Cervical cancer is the third most common cancer among women worldwide. Cervical cancer is significantly associated with human papillomavirus (HPV) infection. The prevalence of HPV infection is influenced by geography, immune status, sexual history and genetic factors. For example, geographically, HPV prevalence varies from 1.5% to 39%. However, little is known about the relationship between HPV prevalence and age. An analysis of HPV prevalence by age will help determine when high-risk groups are exposed to HPV. Such an analysis could also demonstrate a correlation between specific HPV genotypes and age. In addition, the analysis might clarify the optimum age for using vaccines. In this study, HPV prevalence and genotype distribution among Korean and Chinese women are analyzed by age. The REBA HPV-ID$^{(R)}$ assay (YD diagnostics, Yong-in, Republic of Korea) was used for detecting HPV genotypes in uterine cervical liquid-based cytology samples from 533 women from Korea and 324 from East China (Western Shandong province. Women with severe dysplasia such as SCC (Squamous cell carcinoma) and HSIL (High-grade squamous intraepithelial lesion) groups were primarily in their 40s and 50s, whereas women with mild and moderate dysplasia (ASCUS and LSIL groups) were primarily in their 30s and 40s. Women with HPV genotype 16 and 18 infections were primarily in their 40s. The results suggest that HPV infection is associated with certain age groups in the Korean population.

자궁경부암은 전세계 여성에서 세 번째로 많이 발생하는 암이다. 인유두종 바이러스(HPV) 감염이 자궁경부암 발병에 주요한 역할을 한다. HPV 감염은 지리적 위치나 면역학적 상태, 성적 병력, 유전적 요인 등에 영향을 받는다. 예를 들어, HPV 감염률이 스페인에서는 1.5%인 반면, 온두라스와 케냐에서는 39%에 육박한다. 그러나 HPV 감염률과 나이와의 연관성에 대해서는 알려진 바가 적다. 나이에 대한 HPV 감염률 분석은 어느 나이대가 자궁경부암에 고위험군인지를 알아낼 수 있다. 또한 특정 HPV 유전형과 나이 간의 연관성을 입증할 수 있다. 게다가 백신을 주사하는 데에 최적의 나이대를 명확히 알 수 있을 것이다. 이 연구에서는 한국과 중국 여성에서의 HPV 감염률과 유전형 분포를 나이에 따라 분석하였다. 한국과 중국 여성의 자궁 탈락 세포로 REBA HPV-ID$^{(R)}$ 검사법(YD 진단법, 용인, 대한민국)을 통해 HPV 유전형을 파악하였다. 편평세포암과 고등급 병변의 환자군에서는 40대와 50대가 주를 이룬 반면, 중간병변의 환자군에서는 30대와 40대가 주를 이뤘다. HPV 16, 18형 감염은 주로 40대에 속했다. 이러한 결과는 지속적인 감염이 자궁경부암을 일으킨다는 주장을 뒷받침한다.

Keywords

References

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