Korean Journal of Family Medicine (가정의학회지)

The Korean Academy of Family Medicine (대한가정의학회)
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Health-Related Quality of Life and Cardiovascular Disease Risk in Korean Adults

  • Ko, Hyeon-Young (Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Jung-Kwon (Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shin, Jin-Young (Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Jo, Euni (Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2015.02.23
  • Accepted : 2015.10.15
  • Published : 2015.11.30
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Abstract

Background: Health-related quality of life (HRQoL) is considered an important outcome measure in chronic diseases, in particular cardiovascular disease (CVD), which is known to be associated with impaired HRQoL. However, few studies have examined HRQoL in individuals at high risk of CVD. Methods: Using the Fifth Korea National Health and Nutrition Examination Survey 2010-2012, we analyzed data from 10,307 adults aged ${\geq}30years$. The study subjects were stratified into 3 groups on the basis of their Framingham risk score-a 10-year estimate of CVD risk: <10.0% (low risk), 10.0%-19.9% (moderate risk), and ${\geq}20.0%$ (high risk). The EuroQol-5D (EQ-5D) was used to evaluate HRQoL. Results: A significantly higher proportion of high-risk subjects than low-risk participants had impaired HRQoL (defined as the lowest quartile of the EQ-5D index); this held true even after adjustment for confounding factors in multivariable logistic regression analysis (men: odds ratio [OR], 1.62; 95% confidence interval [CI], 1.24-2.11; women: OR, 1.46; 95% CI, 1.02-2.08). In terms of the 5 EQ-5D dimensions, a 10-year CVD risk ${\geq}20.0%$ was significantly associated with self-reported problems of mobility in men (OR, 3.15; 95% CI, 2.02-4.90), and of mobility (OR, 1.56; 95% CI, 1.09-2.24), self-care (OR, 2.14; 95% CI, 1.09-4.22), and usual activity problems (OR, 1.80; 95% CI, 1.17-2.78) in women. Conclusion: A high CVD risk is associated with impaired HRQoL. After adjustment for demographic and clinical factors, a 10-year CVD risk ${\geq}20.0%$ is an independent predictor of impaired HRQoL in the general population; in particular, of mobility problems in men, and of mobility, self-care, and usual activity problems in women.

Keywords

References

  1. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2095-128. https://doi.org/10.1016/S0140-6736(12)61728-0
  2. Alvarez-Bueno C, Cavero-Redondo I, Martinez-Andres M, Arias-Palencia N, Ramos-Blanes R, Salcedo-Aguilar F. Effectiveness of multifactorial interventions in primary health care settings for primary prevention of cardiovascular disease: a systematic review of systematic reviews. Prev Med 2015;76 Suppl:S68-75. https://doi.org/10.1016/j.ypmed.2014.11.028
  3. Cepeda-Valery B, Cheong AP, Lee A, Yan BP. Measuring health related quality of life in coronary heart disease: the importance of feeling well. Int J Cardiol 2011;149:4-9. https://doi.org/10.1016/j.ijcard.2010.09.048
  4. Wenger NK, Mattson ME, Furberg CD, Elinson J. Assessment of quality of life in clinical trials of cardiovascular therapies. Am J Cardiol 1984;54:908-13. https://doi.org/10.1016/S0002-9149(84)80232-5
  5. Centers for Disease Control and Prevention. Measuring healthy days: population assessment of health-related quality of life. Atlanta (GA):Centers for Disease Control and Prevention; 2000.
  6. Xie J, Wu EQ, Zheng ZJ, Sullivan PW, Zhan L, Labarthe DR. Patient-reported health status in coronary heart disease in the United States: age, sex, racial, and ethnic differences. Circulation 2008;118:491-7. https://doi.org/10.1161/CIRCULATIONAHA.107.752006
  7. De Smedt D, Clays E, Annemans L, Doyle F, Kotseva K, Pająk A, et al. Health related quality of life in coronary patients and its association with their cardiovascular risk profile: results from the EUROASPIRE III survey. Int J Cardiol 2013;168:898-903. https://doi.org/10.1016/j.ijcard.2012.10.053
  8. Sullivan PW, Ghushchyan V, Wyatt HR, Wu EQ, Hill JO. Impact of cardiometabolic risk factor clusters on health-related quality of life in the U.S. Obesity (Silver Spring) 2007;15:511-21. https://doi.org/10.1038/oby.2007.580
  9. Ludt S, Wensing M, Szecsenyi J, van Lieshout J, Rochon J, Freund T, et al. Predictors of health-related quality of life in patients at risk for cardiovascular disease in European primary care. PLoS One 2011;6:e29334. https://doi.org/10.1371/journal.pone.0029334
  10. Korea Centers for Disease Control and Prevention. Korean health statistics 2010: Korea National Health and Nutrition Examination Survey (KNHANES V-1). Cheongju: Korea Centers for Disease Control and Prevention; 2011.
  11. Korea Centers for Disease Control and Prevention. Korean health statistics 2011: Korea National Health and Nutrition Examination Survey (KNHANES V-2). Cheongju: Korea Centers for Disease Control and Prevention; 2012.
  12. Korea Centers for Disease Control and Prevention. Korean health statistics 2012: Korea National Health and Nutrition Examination Survey (KNHANES V-3). Cheongju: Korea Centers for Disease Control and Prevention; 2013.
  13. Richardson LC, Wingo PA, Zack MM, Zahran HS, King JB. Health-related quality of life in cancer survivors between ages 20 and 64 years: population-based estimates from the Behavioral Risk Factor Surveillance System. Cancer 2008;112:1380-9. https://doi.org/10.1002/cncr.23291
  14. Alonso J, Ferrer M, Gandek B, Ware JE Jr, Aaronson NK, Mosconi P, et al. Health-related quality of life associated with chronic conditions in eight countries: results from the International Quality of Life Assessment (IQOLA) Project. Qual Life Res 2004;13:283-98. https://doi.org/10.1023/B:QURE.0000018472.46236.05
  15. Lee H, Oh YJ, Kim M, Kim H, Lee JP, Kim S, et al. The association of moderate renal dysfunction with impaired preference-based healthrelated quality of life: third Korean national health and nutritional examination survey. BMC Nephrol 2012;13:19. https://doi.org/10.1186/1471-2369-13-19
  16. D'Agostino RB Sr, Vasan RS, Pencina MJ, Wolf PA, Cobain M, Massaro JM, et al. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 2008;117:743-53. https://doi.org/10.1161/CIRCULATIONAHA.107.699579
  17. Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQol Group. Ann Med 2001;33:337-43. https://doi.org/10.3109/07853890109002087
  18. Nam H, Kim K, Kwon S, Koh K, Poul K. EQ-5D Korean valuation study using time trade of method. Cheongju: Korea Centers for Disease Control and Prevention; 2007.
  19. Blumel JE, Castelo-Branco C, Binfa L, Gramegna G, Tacla X, Aracena B, et al. Quality of life after the menopause: a population study. Maturitas 2000;34:17-23. https://doi.org/10.1016/S0378-5122(99)00081-X
  20. Jiang Y, Hesser JE. Associations between health-related quality of life and demographics and health risks. Results from Rhode Island's 2002 behavioral risk factor survey. Health Qual Life Outcomes 2006;4:14. https://doi.org/10.1186/1477-7525-4-14
  21. Kaplan GA, Keil JE. Socioeconomic factors and cardiovascular disease: a review of the literature. Circulation 1993;88(4 Pt 1):1973-98. https://doi.org/10.1161/01.CIR.88.4.1973
  22. Govil SR, Weidner G, Merritt-Worden T, Ornish D. Socioeconomic status and improvements in lifestyle, coronary risk factors, and quality of life: the Multisite Cardiac Lifestyle Intervention Program. Am J Public Health 2009;99:1263-70. https://doi.org/10.2105/AJPH.2007.132852
  23. Bromberger JT, Meyer PM, Kravitz HM, Sommer B, Cordal A, Powell L, et al. Psychologic distress and natural menopause: a multiethnic community study. Am J Public Health 2001;91:1435-42. https://doi.org/10.2105/AJPH.91.9.1435
  24. Trevisol DJ, Moreira LB, Kerkhoff A, Fuchs SC, Fuchs FD. Health-related quality of life and hypertension: a systematic review and meta-analysis of observational studies. J Hypertens 2011;29:179-88. https://doi.org/10.1097/HJH.0b013e328340d76f
  25. Rubin RR, Peyrot M. Quality of life and diabetes. Diabetes Metab Res Rev 1999;15:205-18. https://doi.org/10.1002/(SICI)1520-7560(199905/06)15:3<205::AID-DMRR29>3.0.CO;2-O
  26. Tillmann M, Silcock J. A comparison of smokers' and ex-smokers' healthrelated quality of life. J Public Health Med 1997;19:268-73. https://doi.org/10.1093/oxfordjournals.pubmed.a024629
  27. Lalonde L, Clarke AE, Joseph L, Mackenzie T, Grover SA; Canadian Collaborative Cardiac Assessment Group. Health-related quality of life with coronary heart disease prevention and treatment. J Clin Epidemiol 2001;54:1011-8. https://doi.org/10.1016/S0895-4356(01)00361-4
  28. Lalonde L, O'Connor A, Joseph L, Grover SA; Canadian Collaborative Cardiac Assessment Group. Health-related quality of life in cardiac patients with dyslipidemia and hypertension. Qual Life Res 2004;13:793-804. https://doi.org/10.1023/B:QURE.0000021695.26201.a0
  29. Bharmal M, Thomas J 3rd. Comparing the EQ-5D and the SF-6D descriptive systems to assess their ceiling effects in the US general population. Value Health 2006;9:262-71. https://doi.org/10.1111/j.1524-4733.2006.00108.x
  30. Kontodimopoulos N, Pappa E, Niakas D, Yfantopoulos J, Dimitrakaki C, Tountas Y. Validity of the EuroQoL (EQ-5D) instrument in a Greek general population. Value Health 2008;11:1162-9. https://doi.org/10.1111/j.1524-4733.2008.00356.x

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