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Effects of Topical Moisturizers on the Skin of Healthy Full-term Infants and Toddlers

국소 보습제 도포가 정상 영유아 피부에 미치는 영향에 관한 연구

  • Hyun, Moo Yeol (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Lee, Yonghee (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Oh, Won Jong (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Yoo, Kwang Ho (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Park, Kui Young (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Kim, Myeung Nam (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Hong, Chang Kwun (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Kim, Beom Joon (Department of Dermatology, Chung-Ang University College of Medicine)
  • 현무열 (중앙대학교 의과대학 피부과학교실) ;
  • 이용희 (중앙대학교 의과대학 피부과학교실) ;
  • 오원종 (중앙대학교 의과대학 피부과학교실) ;
  • 유광호 (중앙대학교 의과대학 피부과학교실) ;
  • 박귀영 (중앙대학교 의과대학 피부과학교실) ;
  • 김명남 (중앙대학교 의과대학 피부과학교실) ;
  • 홍창권 (중앙대학교 의과대학 피부과학교실) ;
  • 김범준 (중앙대학교 의과대학 피부과학교실)
  • Received : 2015.01.26
  • Accepted : 2015.03.18
  • Published : 2015.03.31

Abstract

Moisturizers are the most prescribed products in dermatology. Treatment with moisturizers aims to maintain skin integrity and overall well-being by providing a healthy appearance. Moisturizers perform very important functions in baby care; however, there are few studies on the effects of moisturizers on the skin of infants. To investigate the effects of moisturizers on the skin of healthy full-term infants and toddlers, thirty-one healthy, full-term, 6- to 36-month-old infants and toddlers without any dermatologic conditions received moisturizer applied to the whole body except the eyes and diaper area after bathing twice daily for 4 weeks. Clinical assessments were conducted before treatment, immediately after the treatment period, and 1 and 4 weeks after treatment. At all visits, skin hydration, transepidermal water loss (TEWL), skin pH, and skin roughness were measured, the skin surface was photographed, and any adverse events were recorded. After using moisturizer, skin hydration significantly increased and TEWL and roughness significantly decreased. The skin pH was modified to mildly acidic and the skin surface was visually smoother than before treatment. There were no statistical significant differences of effects of moisturizers according to age and sex, and adverse events were not observed. The results of moisturizer application on the skin were increased skin hydration, recovery of barrier function, balancing skin pH within a mildly acidic range, and increasing the smoothness of the skin surface for 4 weeks.

보습제는 피부과에서 가장 흔하게 사용하는 제품 중 하나로, 피부장벽을 유지시키고 피부가 촉촉하고 건강하게 보이게 하며, 영유아의 정상적인 피부발달에 매우 중요하게 작용한다. 하지만 보습제 도포가 정상 영유아의 피부에 어떠한 영향을 미치는지에 대한 연구는 제한적이다. 이에 건강한 정상 영유아에서 일반적인 보습제 도포가 피부에 미치는 영향을 알아보고자 본 연구를 진행하였다. 31명의 피부염이 동반되지 않는 건강한 6 - 36개월 연령의 영유아를 대상으로, 하루 2회 목욕 후 눈과 기저귀 착용 부위를 제외한 전신에 존슨즈 베이비 내츄럴너리싱 로션을 4주간 도포하였다. 임상적 평가는 도포 전후, 1주, 4주에 실시하였다. 매 방문시 피부수분도와 경표피수분손실도, 피부산도 및 거칠기를 측정하였으며 피부표면을 촬영하여 비교하였고 보습제 도포 후 발생한 피부 발진을 포함한 모든 부작용을 기록하였다. 보습제 도포 후 피부수분도는 통계적으로 유의하게 증가하였으며, 경표피수분손실도와 거칠기는 통계적으로 유의하게 감소하였다. 피부산도는 약산성으로 조절되었으며, 육안적으로 피부표면은 매끄럽게 변화한 것이 관찰되었다. 임상 시험 기간 동안 부작용은 관찰되지 않았다. 본 실험을 통해 보습제 도포가 영유아의 피부에 있어 수분을 증가시키고, 피부장벽기능 증강과 약산성의 피부산도 조절 및 거칠기의 호전을 야기하며, 4주간의 보습제 도포가 미치는 영향의 정도를 확인할 수 있었다.

Keywords

References

  1. M. Loden, The clinical benefit of moisturizers, J. Eur. Acad. Dermatol. Venereol., 19(6), 672 (2005). https://doi.org/10.1111/j.1468-3083.2005.01326.x
  2. T. C. Flynn, J. Petros, R. E. Clark, and G. E.Viehman, Dry skin and moisturizers, Clin. Dermatol., 19(4), 387 (2001). https://doi.org/10.1016/S0738-081X(01)00199-7
  3. Z. D. Draelos, Therapeutic moisturizers, Dermatol. Clin., 18(4), 597 (2000). https://doi.org/10.1016/S0733-8635(05)70210-2
  4. M. Loden, Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders, Am. J. Clin. Dermatol., 4(11), 771 (2003). https://doi.org/10.2165/00128071-200304110-00005
  5. C. D. Coret, M. B. Suero, and N. K. Tierney, Tolerance of natural baby skin-care products on healthy, full-term infants and toddlers, Clin. Cosmet. Investig. Dermatol., 7, 51 (2014).
  6. U. Blume-Peytavi, M. Hauser, G. N. Stamatas, D. Pathirana, and N. Garcia Bartels, Skin care practices for newborns and infants: review of the clinical evidence for best practices, Pediatr. Dermatol., 29(1), 1 (2012). https://doi.org/10.1111/j.1525-1470.2011.01594.x
  7. S. Nicholls, C. S. King, and R. Marks, Short term effects of emollients and a bath oil on the stratum corneum, J. Soc. Cosmet. Chem., 29(10), 617 (1978).
  8. C. A. Garber and C. T. Nightingale, Characterizing cosmetic effects and skin morphology by scanning electron microscopy, J. Soc. Cosmet. Chem., 27(11), 509 (1976).
  9. M. Loden, H. Olsson, L. Skare, Axell T, and Ab AH, Instrumental and sensory evaluation of the frictional response of the skin following a single application of five moisturizing creams, J. Soc. Cosmet. Chem., 43(1), 13 (1992).
  10. M. Loden, The increase in skin hydration after application of emollients with different amounts of lipids, Acta. Derm. Venereol., 72(5), 327 (1992).
  11. W. Gehring, M. Gehse, V. Zimmerman, and M. Gloor, Effects of pH changes in a specific detergent multicomponent emulsion on the water content of stratum corneum, J. Soc. Cosmet. Chem., 42(5), 327 (1991).
  12. E. Simpson, N. S. Trookman, R. L. Rizer, N. Preston, L. E. Colon, and L. A. Johnson, Safety and tolerability of a body wash and moisturizer whenapplied to infants and toddlers with a history of atopic dermatitis: results from an open-label study, Pediatr. Dermatol., 29(5), 590 (2012). https://doi.org/10.1111/j.1525-1470.2012.01809.x
  13. S. Dikstein and A. Zlotogorski, Measurement of skin pH, Acta. Derm. Venereol. Suppl. (Stockh), 185, 18 (1994).
  14. J. L. Matousek and K. L. Campbell, A comparative review of cutaneous pH, Vet. Dermatol., 13(6), 293 (2002). https://doi.org/10.1046/j.1365-3164.2002.00312.x
  15. D. S. Anderson, The acid-base balance of the skin, Br. J. Dermatol., 63(8-9), 283 (1951). https://doi.org/10.1111/j.1365-2133.1951.tb13728.x
  16. H. Ohman and A. Vahlquist, In vivo studies concerning a pH gradient in human stratum corneum and upper epidermis, Acta. Derm. Venereol., 74(5), 375 (1994).
  17. C. Fox, D. Nelson, and J. Wareham, The timing of skin acidification in very low birth weight infants, J. Perinatol., 18(4), 272 (1998).
  18. C. Ehlers, U. I. Ivens, M. L. Møller, T. Senderovitz, and J. Serup, Females have lower skin surface pH than men. A study on the surface of gender, forearm site variation, right/left difference and time of the day on the skin surface pH, Skin Res. Technol., 7(2), 90 (2001). https://doi.org/10.1034/j.1600-0846.2001.70206.x
  19. K. P. Wilhelm, A.B. Cua, and H. I. Maibach, Skin aging. Effect on transepidermal water loss, stratum corneum hydration, skin surface pH, and casual sebum content, Arch. Dermatol., 127(12), 1806 (1991). https://doi.org/10.1001/archderm.1991.04520010052006
  20. A. Zlotogorski, Distribution of skin surface pH on the forehead and cheek of adults, Arch. Dermatol. Res., 279(6), 398 (1987). https://doi.org/10.1007/BF00412626
  21. M. Loden, The skin barrier and use of moisturizers in atopic dermatitis, Clin. Dermatol., 21(2), 145 (2003). https://doi.org/10.1016/S0738-081X(02)00373-5