Gut and Liver

The Korean Association for the Study of the Liver (대한간학회)
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Characteristics of Pediatric Inflammatory Bowel Disease in Korea: Comparison with EUROKIDS Data

  • Lee, Hyeon Ah (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Suk, Jung Yoon (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Choi, Sung Youn (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Kim, Eun Ran (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Young-Ho (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Chang Kyun (Department of Internal Medicine, Kyung Hee University School of Medicine) ;
  • Huh, Kyu Chan (Department of Internal Medicine, Konyang University School of Medicine) ;
  • Lee, Kang Moon (Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea College of Medicine) ;
  • Park, Dong Il (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
  • Received : 2014.09.01
  • Accepted : 2014.10.28
  • Published : 2015.11.15
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Abstract

Background/Aims: Pediatric inflammatory bowel disease (IBD) has been increasing worldwide. The characteristics of pediatric-onset IBD have mainly been reported in Western countries. We investigated the clinical characteristics of pediatric IBD in Korea and compared these with the data from the 5-year European multicenter study of children with new-onset IBD (EUROKIDS registry). Methods: Children who were diagnosed with IBD between July 1987 and January 2012 were investigated at five Korean university hospitals. Their clinical characteristics were retrospectively evaluated by medical record review. The results were compared with the EUROKIDS data. Results: A total of 30 children with Crohn's disease (CD) and 33 children with ulcerative colitis (UC) were enrolled. In comparison with the EUROKIDS group, Korean pediatric IBD patients showed a male predominance (86.7% vs 59.2%, p=0.002 in CD; 75.8% vs 50%, p=0.003 in UC). Korean pediatric CD patients had a higher prevalence of terminal ileal disease (36.7% vs 16.3%, p=0.004) and perianal disease (33.3% vs 8.2%, p<0.001) than patients in the EUROKIDS group. Korean pediatric UC patients had a higher prevalence of proctitis than patients in the EUROKIDS group. Conclusions: Our results suggest that the characteristics of Korean pediatric IBD patients and European pediatric IBD patients may be different.

Keywords

References

  1. Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002; 347:417-429. https://doi.org/10.1056/NEJMra020831
  2. Armitage E, Drummond HE, Wilson DC, Ghosh S. Increasing incidence of both juvenile-onset Crohn's disease and ulcerative colitis in Scotland. Eur J Gastroenterol Hepatol 2001;13:1439-1447. https://doi.org/10.1097/00042737-200112000-00007
  3. Auvin S, Molinie F, Gower-Rousseau C, et al. Incidence, clinical presentation and location at diagnosis of pediatric inflammatory bowel disease: a prospective population-based study in northern France (1988-1999). J Pediatr Gastroenterol Nutr 2005;41:49-55. https://doi.org/10.1097/01.MPG.0000162479.74277.86
  4. Goodhand J, Hedin CR, Croft NM, Lindsay JO. Adolescents with IBD: the importance of structured transition care. J Crohns Colitis 2011;5:509-519. https://doi.org/10.1016/j.crohns.2011.03.015
  5. Jung YS, Song CS, Kim ER, et al. Seasonal variation in months of birth and symptom flares in Korean patients with inflammatory bowel disease. Gut Liver 2013;7:661-667. https://doi.org/10.5009/gnl.2013.7.6.661
  6. Mamula P, Markowitz JE, Baldassano RN. Inflammatory bowel disease in early childhood and adolescence: special considerations. Gastroenterol Clin North Am 2003;32:967-995. https://doi.org/10.1016/S0889-8553(03)00046-3
  7. Sawczenko A, Sandhu BK. Presenting features of inflammatory bowel disease in Great Britain and Ireland. Arch Dis Child 2003;88:995-1000. https://doi.org/10.1136/adc.88.11.995
  8. Kugathasan S, Judd RH, Hoffmann RG, et al. Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study. J Pediatr 2003;143:525-531. https://doi.org/10.1067/S0022-3476(03)00444-X
  9. Yang SK, Yun S, Kim JH, et al. Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986-2005: a KASID study. Inflamm Bowel Dis 2008;14:542-549. https://doi.org/10.1002/ibd.20310
  10. Kim BJ, Song SM, Kim KM, et al. Characteristics and trends in the incidence of inflammatory bowel disease in Korean children: a single-center experience. Dig Dis Sci 2010;55:1989-1995. https://doi.org/10.1007/s10620-009-0963-5
  11. Lee NY, Park JH. Clinical features and course of Crohn disease in children. Korean J Gastrointest Endosc 2007;34:193-199.
  12. Song SM, Kim Y, Oh SH, Kim KM. Nutritional status and growth in Korean children with Crohn's disease: a single-center study. Gut Liver 2014;8:500-507. https://doi.org/10.5009/gnl13183
  13. de Bie CI, Paerregaard A, Kolacek S, et al. Disease phenotype at diagnosis in pediatric Crohn's disease: 5-year analyses of the EUROKIDS Registry. Inflamm Bowel Dis 2013;19:378-385. https://doi.org/10.1002/ibd.23008
  14. Levine A, de Bie CI, Turner D, et al. Atypical disease phenotypes in pediatric ulcerative colitis: 5-year analyses of the EUROKIDS Registry. Inflamm Bowel Dis 2013;19:370-377. https://doi.org/10.1002/ibd.23013
  15. Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 1989;170:2-6.
  16. Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006;55:749-753. https://doi.org/10.1136/gut.2005.082909
  17. Ouyang Q, Tandon R, Goh KL, Ooi CJ, Ogata H, Fiocchi C. The emergence of inflammatory bowel disease in the Asian Pacific region. Curr Opin Gastroenterol 2005;21:408-413.
  18. Loftus EV Jr, Schoenfeld P, Sandborn WJ. The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: a systematic review. Aliment Pharmacol Ther 2002;16:51-60. https://doi.org/10.1046/j.1365-2036.2002.01140.x
  19. Ye BD, Yang SK, Cho YK, et al. Clinical features and long-term prognosis of Crohn's disease in Korea. Scand J Gastroenterol 2010; 45:1178-1185. https://doi.org/10.3109/00365521.2010.497936
  20. Park JB, Yang SK, Myung SJ, et al. Clinical characteristics at diagnosis and course of Korean patients with Crohn's disease. Korean J Gastroenterol 2004;43:8-17.
  21. Muller KE, Lakatos PL, Arato A, et al. Incidence, Paris classification, and follow-up in a nationwide incident cohort of pediatric patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2013;57:576-582. https://doi.org/10.1097/MPG.0b013e31829f7d8c
  22. Hope B, Shahdadpuri R, Dunne C, et al. Rapid rise in incidence of Irish paediatric inflammatory bowel disease. Arch Dis Child 2012; 97:590-594. https://doi.org/10.1136/archdischild-2011-300651
  23. Malmborg P, Grahnquist L, Lindholm J, Montgomery S, Hildebrand H. Increasing incidence of paediatric inflammatory bowel disease in northern Stockholm County, 2002-2007. J Pediatr Gastroenterol Nutr 2013;57:29-34. https://doi.org/10.1097/MPG.0b013e31828f21b4
  24. Eszter Muller K, Laszlo Lakatos P, Papp M, Veres G. Incidence and paris classification of pediatric inflammatory bowel disease. Gastroenterol Res Pract 2014;2014:904307.
  25. Ng SC, Tang W, Ching JY, et al. Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study. Gastroenterology 2013; 145:158-165. https://doi.org/10.1053/j.gastro.2013.04.007
  26. Lok KH, Hung HG, Ng CH, Li KK, Li KF, Szeto ML. The epidemiology and clinical characteristics of Crohn's disease in the Hong Kong Chinese population: experiences from a regional hospital. Hong Kong Med J 2007;13:436-441.
  27. American Gastroenterological Association Clinical Practice Committee. American Gastroenterological Association medical position statement: perianal Crohn's disease. Gastroenterology 2003;125:1503-1507. https://doi.org/10.1016/j.gastro.2003.08.024
  28. Schwartz DA, Loftus EV Jr, Tremaine WJ, et al. The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota. Gastroenterology 2002;122:875-880. https://doi.org/10.1053/gast.2002.32362
  29. Van Limbergen J, Russell RK, Drummond HE, et al. Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology 2008;135:1114-1122. https://doi.org/10.1053/j.gastro.2008.06.081
  30. Levine A, Griffiths A, Markowitz J, et al. Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification. Inflamm Bowel Dis 2011;17:1314-1321. https://doi.org/10.1002/ibd.21493
  31. da Silva BC, Lyra AC, Rocha R, Santana GO. Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis. World J Gastroenterol 2014;20:9458-9467. https://doi.org/10.3748/wjg.v20.i28.9458
  32. Park SH, Kim YM, Yang SK, et al. Clinical features and natural history of ulcerative colitis in Korea. Inflamm Bowel Dis 2007;13: 278-283. https://doi.org/10.1002/ibd.20015

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