DOI QR코드

DOI QR Code

Fibula Free Flap for Mandibular Reconstruction using Simulation Surgery in Bisphosphonate related Osteonecrosis of the Jaw

  • Kim, Hong-Joon (Department of Oral and Maxillofacial Surgery, College of Medicine, University of Ulsan, Asan Medical Center) ;
  • Hwang, Jong-Hyun (Department of Oral and Maxillofacial Surgery, College of Medicine, University of Ulsan, Asan Medical Center) ;
  • Ahn, Kang-Min (Department of Oral and Maxillofacial Surgery, College of Medicine, University of Ulsan, Asan Medical Center)
  • Received : 2015.05.07
  • Accepted : 2015.05.20
  • Published : 2015.06.10

Abstract

Purpose Bisphophonate-related osteonecrosis of the jaw (BRONJ) is an emerging problem. Extensive osteonecrosis of the jaw needs free flap reconstruction. Free fibular flap is the most useful flap for maxilla-mandibular hard and soft tissue reconstruction. The advantages of fibular free flap are simultaneous soft and hard tissue reconstruction and placing implant in reconstructed mandible and maxilla. In this study, four consecutive BRONJ patients who underwent fibula free flap reconstruction using simulation surgery were reviewed. Materials and Methods Four BRONJ patients who underwent free fibula reconstruction between May 2006 and September 2014 were included in this study. Male to female ratio was 1:3 and average age was 67.3 years old (62-70). All patients need mandibular bone reconstruction. Three patients suffered from osteoporosis and one male patient had multiple myeloma. Postoperative flap survival, functional reconstruction, esthetic results, food taking were evaluated. Results Three osseous flaps and one osteocutaneous flap were used. All the fibular flaps were survived and patients were recovered without complications. Oro-cutaneous fistula was resolved after operation. All patients were satisfied with the esthetic results. Patients reported improved solid food intake after operation with partial denture. One fully edentulous patient had semi-fluid diet after operation. Conclusion Treatment of the BRONJ is difficult due to lack of standard protocol. Fibular free flap using simulation surgery is the workhorse flap for mandibular hard and soft tissue reconstruction, especially in stage III BRONJ patient. In this study, functional and esthetic results were successful in all patients. Normal diet was possible with partial dentures.

Keywords

References

  1. Marx RE. Pamidronate (aredia) and zoledronate (zometa) induced avascular necrosis of the jaws: A growing epidemic. J Oral Maxillofac Surg 2003;61:1115-1117 https://doi.org/10.1016/S0278-2391(03)00720-1
  2. Tam Y, Kar K, Nowzari H, Cha HS, Ahn KM. Osteonecrosis of the jaw after implant surgery in patients treated with bisphosphonates--a presentation of six consecutive cases. Clinical implant dentistry and related research 2014;16:751-761 https://doi.org/10.1111/cid.12048
  3. Hewitt C, Farah CS. Bisphosphonate-related osteonecrosis of the jaws: A comprehensive review. J Oral Pathol Med 2007;36:319-328 https://doi.org/10.1111/j.1600-0714.2007.00540.x
  4. Ahn K. Multiple myeloma: Chapter 8. Bisphosphonate related osteonecrosis of the jaw New York: Nova, 2014
  5. Advisory Task Force on Bisphosphonate-Related Ostenonecrosis of the Jaws AAoO, Maxillofacial S. American association of oral and maxillofacial surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 2007;65:369-376 https://doi.org/10.1016/j.joms.2006.11.003
  6. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, et al. American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw--2014 update. J Oral Maxillofac Surg 2014;72:1938-1956 https://doi.org/10.1016/j.joms.2014.04.031
  7. Ferrari S, Bianchi B, Savi A, Poli T, Multinu A, Balestreri A, et al. Fibula free flap with endosseous implants for reconstructing a resected mandible in bisphosphonate osteonecrosis. J Oral Maxillofac Surg 2008;66:999-1003 https://doi.org/10.1016/j.joms.2007.06.631
  8. Nocini PF, Saia G, Bettini G, Ragazzo M, Blandamura S, Chiarini L, et al. Vascularized fibula flap reconstruction of the mandible in bisphosphonate-related osteonecrosis. Eur J Surg Oncol 2009;35:373-379 https://doi.org/10.1016/j.ejso.2008.05.002
  9. Sacco R, Sacco G, Acocella A, Sale S, Sacco N, Baldoni E. A systematic review of microsurgical reconstruction of the jaws using vascularized fibula flap technique in patients with bisphosphonate-related osteonecrosis. J Appl Oral Sci 2011;19:293-300 https://doi.org/10.1590/S1678-77572011000400001
  10. Ghazali N, Collyer JC, Tighe JV. Hemimandibulectomy and vascularized fibula flap in bisphosphonate-induced mandibular osteonecrosis with polycythaemia rubra vera. Int J Oral Maxillofac Surg 2013;42:120-123 https://doi.org/10.1016/j.ijom.2012.03.019
  11. Hanasono MM, Militsakh ON, Richmon JD, Rosenthal EL, Wax MK. Mandibulectomy and free flap reconstruction for bisphosphonate-related osteonecrosis of the jaws. JAMA Otolaryngol Head Neck Surg 2013;139:1135-1142 https://doi.org/10.1001/jamaoto.2013.4474
  12. Levine JP, Bae JS, Soares M, Brecht LE, Saadeh PB, Ceradini DJ, et al. Jaw in a day: Total maxillofacial reconstruction using digital technology. Plast Reconstr Surg 2013;131:1386-1391 https://doi.org/10.1097/PRS.0b013e31828bd8d0
  13. Bagan JV, Cibrian RM, Lopez J, Leopoldo-Rodado M, Carbonell E, Bagan L, et al. Sclerosis in bisphosphonate-related osteonecrosis of the jaws and its correlation with the clinical stages: Study of 43 cases. Br J Oral Maxillofac Surg 2015;53:257-262 https://doi.org/10.1016/j.bjoms.2014.12.004
  14. Pichardo SE, Richard van Merkesteyn JP. Bisphosphonate-related osteonecrosis of the jaws of dental origin. Oral Surg Oral Med Oral Pathol Oral Radiol 2014;117:393 https://doi.org/10.1016/j.oooo.2013.10.003
  15. Kos M. Association of dental and periodontal status with bisphosphonate-related osteonecrosis of the jaws. A retrospective case controlled study. Arch Med Sci 2014;10:117-123
  16. Lerman MA, Xie W, Treister NS, Richardson PG, Weller EA, Woo SB. Conservative management of bisphosphonate-related osteonecrosis of the jaws: Staging and treatment outcomes. Oral Oncol 2013;49:977-983 https://doi.org/10.1016/j.oraloncology.2013.05.012
  17. Kuhl S, Walter C, Acham S, Pfeffer R, Lambrecht JT. Bisphosphonate-related osteonecrosis of the jaws--a review. Oral Oncol 2012;48:938-947 https://doi.org/10.1016/j.oraloncology.2012.03.028
  18. Seth R, Futran ND, Alam DS, Knott PD. Outcomes of vascularized bone graft reconstruction of the mandible in bisphosphonate-related osteonecrosis of the jaws. The Laryngoscope 2010;120:2165-2171 https://doi.org/10.1002/lary.21062
  19. Pautke C, Otto S, Reu S, Kolk A, Ehrenfeld M, Sturzenbaum S, et al. Bisphosphonate related osteonecrosis of the jaw--manifestation in a microvascular iliac bone flap. Oral oncology 2011;47:425-429 https://doi.org/10.1016/j.oraloncology.2011.03.022

Cited by

  1. Microsurgical Reconstruction of the Jaws Using Vascularised Free Flap Technique in Patients with Medication-Related Osteonecrosis: A Systematic Review vol.2018, pp.2314-6141, 2018, https://doi.org/10.1155/2018/9858921