Sleep Medicine and Psychophysiology (수면정신생리)

KOREAN ACADEMY OF SLEEP MEDICINE (대한수면의학회)
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Melatonin in Psychiatric Disorders

멜라토닌과 정신과 질환

  • Lee, Jin-Seong (Department of Neuropsychiatry, Pusan National University Yangsan Hospital) ;
  • Kim, Sung-Gon (Department of Neuropsychiatry, Pusan National University Yangsan Hospital) ;
  • Kim, Ji-Hoon (Department of Neuropsychiatry, Pusan National University Yangsan Hospital) ;
  • Jung, Woo-Young (Department of Neuropsychiatry, Pusan National University Yangsan Hospital) ;
  • Park, Ji-Hoon (Department of Neuropsychiatry, Pusan National University Yangsan Hospital)
  • 이진성 (양산부산대학교병원 정신건강의학과) ;
  • 김성곤 (양산부산대학교병원 정신건강의학과) ;
  • 김지훈 (양산부산대학교병원 정신건강의학과) ;
  • 정우영 (양산부산대학교병원 정신건강의학과) ;
  • 박지훈 (양산부산대학교병원 정신건강의학과)
  • Received : 2015.05.04
  • Accepted : 2015.06.15
  • Published : 2015.06.30
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Abstract

The secretion of melatonin exhibits a circadian rhythm entrained with the sleep-wake cycle. An alteration of this secretory rhythm has been found in various psychiatric disorders. This review summarizes the regulation of melatonin and its relationship to the circadian rhythm, major depressive disorder, bipolar disorder, seasonal affective disorder, Alzheimer's disease and autism. The review also looks at the effect of melatonin and melatonin agonist on sleep and symptoms of depression, bipolar disorder and seasonal affective disorder. In Alzheimer's disease, the circadian rhythm alterations are associated with the change of melatonin levels and melatonin receptors. It has been reported that melatonin and melatonin synthetic enzyme levels decrease in autism spectrum disorder.

Keywords

References

  1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. Washington, D.C., American Psychiatric Publishing;2013.
  2. Ancoli-Israel S. Sleep and aging: prevalence of disturbed sleep and treatment considerations in older adults. J Clin Psychiatry 2005; 66 Suppl 9:24-30; quiz 42-23.
  3. Ancoli-Israel S, Ayalon L, Salzman C. Sleep in the elderly: normal variations and common sleep disorders. Harv Rev Psychiatry 2008;16:279-286. https://doi.org/10.1080/10673220802432210
  4. Arendt J. Melatonin: a new probe in psychiatric investigation? Br J Psychiatry 1989;155:585-590.
  5. Bartness TJ, Goldman BD. Mammalian pineal melatonin: a clock for all seasons. Experientia 1989;45:939-945. https://doi.org/10.1007/BF01953051
  6. Benedetti F, Colombo C, Barbini B, Campori E, Smeraldi E. Morning sunlight reduces length of hospitalization in bipolar depression. J Affect Disord 2001;62:221-223. https://doi.org/10.1016/S0165-0327(00)00149-X
  7. Benedetti F, Colombo C, Serretti A, Lorenzi C, Pontiggia A, Barbini B, et al. Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Biol Psychiatry 2003;54:687-692. https://doi.org/10.1016/S0006-3223(02)01894-2
  8. Benedetti F, Dallaspezia S, Fulgosi MC, Barbini B, Colombo C, Smeraldi E. Phase advance is an actimetric correlate of antidepressant response to sleep deprivation and light therapy in bipolar depression. Chronobiol Int 2007;24:921-937. https://doi.org/10.1080/07420520701649455
  9. Bersani G, Garavini A. Melatonin add-on in manic patients with treatment resistant insomnia. Prog Neuropsychopharmacol Biol Psychiatry 2000;24:185-191. https://doi.org/10.1016/S0278-5846(99)00097-4
  10. Brunner P, Sozer-Topcular N, Jockers R, Ravid R, Angeloni D, Fraschini F, et al. Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer's disease. Eur J Histochem 2006;50:311-316.
  11. Colombo C, Lucca A, Benedetti F, Barbini B, Campori E, Smeraldi E. Total sleep deprivation combined with lithium and light therapy in the treatment of bipolar depression: replication of main effects and interaction. Psychiatry Res 2000;95:43-53. https://doi.org/10.1016/S0165-1781(00)00164-5
  12. Cortesi F, Giannotti F, Sebastiani T, Panunzi S, Valente D. Controlled-release melatonin, singly and combined with cognitive behavioural therapy, for persistent insomnia in children with autism spectrum disorders: a randomized placebo-controlled trial. J Sleep Res 2012;21:700-709. https://doi.org/10.1111/j.1365-2869.2012.01021.x
  13. Delagrange P, Boutin JA. Therapeutic potential of melatonin ligands. Chronobiol Int 2006;23:413-418. https://doi.org/10.1080/07420520500464387
  14. Dowling GA, Burr RL, Van Someren EJ, Hubbard EM, Luxenberg JS, Mastick J, et al. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease. J Am Geriatr Soc 2008;56:239-246. https://doi.org/10.1111/j.1532-5415.2007.01543.x
  15. Dubocovich ML, Markowska M. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine 2005;27:101-110. https://doi.org/10.1385/ENDO:27:2:101
  16. Eastman CI, Young MA, Fogg LF, Liu L, Meaden PM. Bright light treatment of winter depression: a placebo-controlled trial. Arch Gen Psychiatry 1998;55:883-889. https://doi.org/10.1001/archpsyc.55.10.883
  17. Ferrari E, Arcaini A, Gornati R, Pelanconi L, Cravello L, Fioravanti M, et al. Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia. Exp Gerontol 2000;35:1239-1250. https://doi.org/10.1016/S0531-5565(00)00160-1
  18. Fornaro M, McCarthy MJ, De Berardis D, De Pasquale C, Tabaton M, Martino M, et al. Adjunctive agomelatine therapy in the treatment of acute bipolar II depression: a preliminary open label study. Neuropsychiatric Disease and Treatment 2013;9:243-251.
  19. Gringras P, Gamble C, Jones AP, Wiggs L, Williamson PR, Sutcliffe A, et al. Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial. BMJ 2012;345:e6664. https://doi.org/10.1136/bmj.e6664
  20. Grunhaus L, Hirschman S, Dolberg OT, Schreiber S, Dannon PN. Coadministration of melatonin and fluoxetine does not improve the 3-month outcome following ECT. J ECT 2001;17:124-128. https://doi.org/10.1097/00124509-200106000-00007
  21. Hallam KT, Olver JS, Chambers V, Begg DP, McGrath C, Norman TR. The heritability of melatonin secretion and sensitivity to bright nocturnal light in twins. Psychoneuroendocrinology 2006;31:867-875. https://doi.org/10.1016/j.psyneuen.2006.04.004
  22. Kasper S, Hajak G, Wulff K, Hoogendijk WJ, Montejo AL, Smeraldi E, et al. Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline. J Clin Psychiatry 2010;71:109-120. https://doi.org/10.4088/JCP.09m05347blu
  23. Kennedy SH, Kutcher SP, Ralevski E, Brown GM. Nocturnal melatonin and 24-hour 6-sulphatoxymelatonin levels in various phases of bipolar affective disorder. Psychiatry Res 1996;63:219-222. https://doi.org/10.1016/0165-1781(96)02910-1
  24. Kennedy SH, Tighe S, McVey G, Brown GM. Melatonin and cortisol "switches" during mania, depression, and euthymia in a drug-free bipolar patient. J Nerv Ment Dis 1989;177:300-303. https://doi.org/10.1097/00005053-198905000-00009
  25. Lee H, Cho CH, Kim L. Human circadian rhythms. Sleep Med Psychophysiol 2014;21:51-60. https://doi.org/10.14401/KASMED.2014.21.2.51
  26. Lemoine P, Guilleminault C, Alvarez E. Improvement in subjective sleep in major depressive disorder with a novel antidepressant, agomelatine: randomized, double-blind comparison with venlafaxine. J Clin Psychiatry 2007;68:1723-1732. https://doi.org/10.4088/JCP.v68n1112
  27. Lewy AJ, Nurnberger JI Jr, Wehr TA, Pack D, Becker LE, Powell RL, et al. Supersensitivity to light: possible trait marker for manic-depressive illness. Am J Psychiatry 1985;142:725-727. https://doi.org/10.1176/ajp.142.6.725
  28. Lewy AJ. Melatonin and human chronobiology. Cold Spring Harb Symp Quant Biol 2007;72:623-636. https://doi.org/10.1101/sqb.2007.72.055
  29. Lewy AJ, Lefler BJ, Emens JS, Bauer VK. The circadian basis of winter depression. Proc Natl Acad Sci U S A 2006;103:7414-7419. https://doi.org/10.1073/pnas.0602425103
  30. Luboshitzky R, Shen-Orr Z, Tzischichinsky O, Maldonado M, Herer P, Lavie P. Actigraphic sleep-wake patterns and urinary 6-sulfatoxymelatonin excretion in patients with Alzheimer's disease. Chronobiol Int 2001;18:513-524. https://doi.org/10.1081/CBI-100103973
  31. Lynch HJ, Ozaki Y, Wurtman RJ. The measurement of melatonin in mammalian tissues and body fluids. J Neural Transm Suppl 1978:251-264.
  32. Mahlberg R, Walther S, Kalus P, Bohner G, Haedel S, Reischies FM, et al. Pineal calcification in Alzheimer's disease: an in vivo study using computed tomography. Neurobiol Aging 2008;29:203-209. https://doi.org/10.1016/j.neurobiolaging.2006.10.003
  33. Melke J, Goubran Botros H, Chaste P, Betancur C, Nygren G, Anckarsater H, et al. Abnormal melatonin synthesis in autism spectrum disorders. Mol Psychiatry 2008;13:90-98. https://doi.org/10.1038/sj.mp.4002016
  34. Montgomery SA, Kasper S. Severe depression and antidepressants: focus on a pooled analysis of placebo-controlled studies on agomelatine. Int Clin Psychopharmacol 2007;22:283-291. https://doi.org/10.1097/YIC.0b013e3280c56b13
  35. Murphy MJ, Peterson MJ. Sleep Disturbances in Depression. Sleep Med Clin 2015;10:17-23. https://doi.org/10.1016/j.jsmc.2014.11.009
  36. Nagy AD, Iwamoto A, Kawai M, Goda R, Matsuo H, Otsuka T, et al. Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder. Chronobiology International 2015;32:447-457. https://doi.org/10.3109/07420528.2014.992525
  37. Nathan PJ, Burrows GD, Norman TR. Melatonin sensitivity to dim white light in affective disorders. Neuropsychopharmacology 1999;21:408-413. https://doi.org/10.1016/S0893-133X(99)00018-4
  38. Nosjean O, Ferro M, Coge F, Beauverger P, Henlin JM, Lefoulon F, et al. Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem 2000;275:31311-31317. https://doi.org/10.1074/jbc.M005141200
  39. Nurnberger JI Jr, Adkins S, Lahiri DK, Mayeda A, Hu K, Lewy A, et al. Melatonin suppression by light in euthymic bipolar and unipolar patients. Arch Gen Psychiatry 2000;57:572-579. https://doi.org/10.1001/archpsyc.57.6.572
  40. Pandi-Perumal SR, Trakht I, Srinivasan V, Spence DW, Maestroni GJ, Zisapel N, et al. Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways. Prog Neurobiol 2008;85:335-353. https://doi.org/10.1016/j.pneurobio.2008.04.001
  41. Parry BL, Meliska CJ, Sorenson DL, Lopez AM, Martinez LF, Nowakowski S, et al. Increased melatonin and delayed offset in menopausal depression: role of years past menopause, follicle-stimulating hormone, sleep end time, and body mass index. J Clin Endocrinol Metab 2008;93:54-60. https://doi.org/10.1210/jc.2006-2853
  42. Pjrek E, Winkler D, Konstantinidis A, Willeit M, Praschak-Rieder N, Kasper S. Agomelatine in the treatment of seasonal affective disorder. Psychopharmacology (Berl) 2007;190:575-579. https://doi.org/10.1007/s00213-006-0645-3
  43. Quera-Salva MA, Hajak G, Philip P, Montplaisir J, Keufer-Le Gall S, Laredo J, et al. Comparison of agomelatine and escitalopram on nighttime sleep and daytime condition and efficacy in major depressive disorder patients. Int Clin Psychopharmacol 2011;26:252-262. https://doi.org/10.1097/YIC.0b013e328349b117
  44. Rao AV, Devi SP, Srinivasan V. Urinary melatonin in depression. Indian J Psychiatry 1983;25:167-172.
  45. Sack RL, Lewy AJ, White DM, Singer CM, Fireman MJ, Vandiver R. Morning vs evening light treatment for winter depression. Evidence that the therapeutic effects of light are mediated by circadian phase shifts. Arch Gen Psychiatry 1990;47:343-351. https://doi.org/10.1001/archpsyc.1990.01810160043008
  46. Savaskan E, Ayoub MA, Ravid R, Angeloni D, Fraschini F, Meier F, et al. Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease. J Pineal Res 2005;38:10-16. https://doi.org/10.1111/j.1600-079X.2004.00169.x
  47. Savaskan E, Olivieri G, Meier F, Brydon L, Jockers R, Ravid R, et al. Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients. J Pineal Res 2002;32:59-62. https://doi.org/10.1034/j.1600-079x.2002.00841.x
  48. Singer C, Tractenberg RE, Kaye J, Schafer K, Gamst A, Grundman M, et al. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease. Sleep 2003;26:893-901. https://doi.org/10.1093/sleep/26.7.893
  49. Skene DJ, Swaab DF. Melatonin rhythmicity: effect of age and Alzheimer's disease. Exp Gerontol 2003;38:199-206. https://doi.org/10.1016/S0531-5565(02)00198-5
  50. Srinivasan V, Smits M, Spence W, Lowe AD, Kayumov L, Pandi-Perumal SR, et al. Melatonin in mood disorders. World J Biol Psychiatry 2006;7:138-151. https://doi.org/10.1080/15622970600571822
  51. Terman JS, Terman M, Lo ES, Cooper TB. Circadian time of morning light administration and therapeutic response in winter depression. Arch Gen Psychiatry 2001;58:69-75. https://doi.org/10.1001/archpsyc.58.1.69
  52. Thorpe M, Pannell J, Nance M. Agomelatine-associated manic switch in bipolar depression: a case report. Aust N Z J Psychiatry 2014;48:958-959.
  53. van Someren EJ, Hagebeuk EE, Lijzenga C, Scheltens P, de Rooij SE, Jonker C, et al. Circadian rest-activity rhythm disturbances in Alzheimer's disease. Biol Psychiatry 1996;40:259-270. https://doi.org/10.1016/0006-3223(95)00370-3
  54. Wahlund B, Grahn H, Saaf J, Wetterberg L. Affective disorder subtyped by psychomotor symptoms, monoamine oxidase, melatonin and cortisol: identification of patients with latent bipolar disorder. Eur Arch Psychiatry Clin Neurosci 1998;248:215-224. https://doi.org/10.1007/s004060050041
  55. Wehr TA, Duncan WC Jr, Sher L, Aeschbach D, Schwartz PJ, Turner EH, et al. A circadian signal of change of season in patients with seasonal affective disorder. Arch Gen Psychiatry 2001;58:1108-1114. https://doi.org/10.1001/archpsyc.58.12.1108
  56. Weitzman ED, Weinberg U, D'Eletto R, Lynch H, Wurtman RJ, Czeisler C, et al. Studies of the 24 hour rhythm of melatonin in man. J Neural Transm Suppl 1978:325-337.
  57. Wetterberg L. Clinical importance of melatonin. Prog Brain Res 1979;52:539-547. https://doi.org/10.1016/S0079-6123(08)62962-3
  58. Wirojanan J, Jacquemont S, Diaz R, Bacalman S, Anders TF, Hagerman RJ, et al. The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome. J Clin Sleep Med 2009;5:145-150.
  59. Wirz-Justice A, Quinto C, Cajochen C, Werth E, Hock C. A rapid-cycling bipolar patient treated with long nights, bedrest, and light. Biol Psychiatry 1999;45:1075-1077. https://doi.org/10.1016/S0006-3223(98)00289-3
  60. Wright B, Sims D, Smart S, Alwazeer A, Alderson-Day B, Allgar V, et al. Melatonin versus placebo in children with autism spectrum conditions and severe sleep problems not amenable to behaviour management strategies: a randomised controlled crossover trial. J Autism Dev Disord 2011;41:175-184. https://doi.org/10.1007/s10803-010-1036-5
  61. Wu YH, Fischer DF, Kalsbeek A, Garidou-Boof ML, van der Vliet J, van Heijningen C, et al. Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the "master clock". FASEB J 2006;20:1874-1876. https://doi.org/10.1096/fj.05-4446fje
  62. Wu YH, Swaab DF. Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer's disease. Sleep Med 2007;8:623-636. https://doi.org/10.1016/j.sleep.2006.11.010
  63. Wu YH, Zhou JN, Van Heerikhuize J, Jockers R, Swaab DF. Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease. Neurobiol Aging 2007;28:1239-1247. https://doi.org/10.1016/j.neurobiolaging.2006.06.002
  64. Yatham LN, Vieta E, Goodwin GM, Bourin M, de Bodinat C, Laredo J, et al. Agomelatine or placebo as adjunctive therapy to a mood stabiliser in bipolar I depression: randomised double-blind placebo-controlled trial. Br J Psychiatry 2015 (DOI: 10.1192/bjp.bp.114.147587).

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