Journal of the Korean Crystal Growth and Crystal Technology (한국결정성장학회지)

The Korea Association of Crystal Growth (한국결정성장학회)
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Preparation and characterization of silanized-hydroxypropyl methylcellulose/phase transformed calcium phosphate composite bone cements

실란처리된 하이드록시프로필 메틸셀룰로오스/상전이된 칼슘포스페이트 복합체 골시멘트의 제조 및 특성평가

  • 정나현 (부산대학교 재료공학부) ;
  • 김동현 (유펙스.메드 기술개발부) ;
  • 조훈상 (유펙스.메드 기술개발부) ;
  • 윤석영 (부산대학교 재료공학부)
  • Received : 2016.11.07
  • Accepted : 2016.11.21
  • Published : 2016.12.31
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Abstract

Silanized-hydroxypropyl methylcellulose (Si-HPMC)/phase transformed calcium phosphate (PTCP) composites are prepared to purpose application of injectable bone cements with enhanced biocompatibility. The crystal structure and chemical state of the synthesized PTCP and Si-HPMC as solid and liquid phase of the composite cements were measured by XRD and FT-IR. The handling and mechanical properties of cements were measured by injectability tests and three-point bending tests. The in-vitro mechanical properties, XRD, and SEM results of bone cements were showed that enhanced hardening behavior was an inherent function of bone cements after in-vitro test. The cytotoxicity result of bone cements also was showed enhanced biocompatibility. Therefore, these injectable cements had potential be used as calcium phosphate cements for biomedical applications.

실란처리된 하이드록시프로필 메틸셀룰로오스/상전이된 칼슘포스페이트 복합체 시멘트는 향상된 생체적합성을 가지는 주입이 가능한 골시멘트로서 제조 되었다. 복합체 시멘트의 고체상과 액체상으로서 상전이된 칼슘포스페이트와 실란처리된 하이드록시프로필 메틸셀룰로오스의 결정구조 및 화학적 상태는 XRD 및 FT-IR에 의해 측정 되었고, 시멘트의 조작성 및 기계적 물성은 주입성 및 3점 굽힘 시험에 의해 측정하였다. 체외에서 진행된 골시멘트의 기계적 물성, XRD 및 SEM 결과는 골시멘트의 고유 기능으로서의 향상된 경화거동을 보였다. 또한 골시멘트의 세포독성 결과 향상된 생체적합성을 보였다. 따라서 이러한 주입이 가능한 시멘트는 생체의학 응용에 대한 칼슘포스페이트 시멘트로서 사용이 가능하리라 판단되어진다.

Keywords

References

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