Allergy, Asthma & Immunology Research

The Korean Academy of Asthma, Allergy and Clinical Immunology (대한천식알레르기학회)
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A Multicenter Retrospective Case Study of Anaphylaxis Triggers by Age in Korean Children

  • Lee, So-Yeon (Department of Pediatrics, Hallym University College of Medicine) ;
  • Ahn, Kangmo (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Jihyun (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Jang, Gwang Cheon (Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital) ;
  • Min, Taek Ki (Department of Pediatrics, Soonchunhyang University Hospital) ;
  • Yang, Hyeon-Jong (Department of Pediatrics, Soonchunhyang University Hospital) ;
  • Pyun, Bok Yang (Department of Pediatrics, Soonchunhyang University Hospital) ;
  • Kwon, Ji-Won (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Sohn, Myung Hyun (Department of Pediatrics, Yonsei University College of Medicine) ;
  • Kim, Kyung Won (Department of Pediatrics, Yonsei University College of Medicine) ;
  • Kim, Kyu-Earn (Department of Pediatrics, Yonsei University College of Medicine) ;
  • Yu, Jinho (Department of Pediatrics, University of Ulsan College of Medicine) ;
  • Hong, Soo-Jong (Department of Pediatrics, University of Ulsan College of Medicine) ;
  • Kwon, Jung Hyun (Department of Pediatrics, Korea University, College of Medicine) ;
  • Kim, Sung-Won (Department of Pediatrics, Pusan Saint Maria Hospital) ;
  • Song, Tae Won (Department of Pediatrics, Inje University College of Medicine) ;
  • Kim, Woo Kyung (Department of Pediatrics, Inje University College of Medicine) ;
  • Kim, Hyung Young (Department of Pediatrics, Pusan National University School of Medicine) ;
  • Jeon, You Hoon (Department of Pediatrics, Hallym University College of Medicine) ;
  • Lee, Yong Ju (Department of Pediatrics, Hallym University College of Medicine) ;
  • Lee, Hae Ran (Department of Pediatrics, Hallym University College of Medicine) ;
  • Kim, Hye-Young (Department of Pediatrics, Pusan National University School of Medicine) ;
  • Ahn, Youngmin (Department of Pediatrics, Eulji University School of Medicine) ;
  • Yum, Hye Yung (Department of Pediatrics, Seoul Medical Center) ;
  • Suh, Dong In (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Kim, Hyun Hee (Department of Pediatrics, The Catholic University of Korea College of Medicine) ;
  • Kim, Jin-Tack (Department of Pediatrics, The Catholic University of Korea College of Medicine) ;
  • Kim, Jeong Hee (Department of Pediatrics, Inha University College of Medicine) ;
  • Park, Yong Mean (Department of Pediatrics, Konkuk University School of Medicin) ;
  • Lee, Sooyoung (Department of Pediatrics, Ajou University School of Medicine) ;
  • Korean Academy of Pediatric Allergy and Respiratory Diseases Food Allergy and Atopic Dermatitis Study Group (Korean Academy of Pediatric Allergy and Respiratory Diseases Food Allergy and Atopic Dermatitis Study Group)
  • Received : 2016.02.28
  • Accepted : 2016.05.26
  • Published : 2016.11.01
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Abstract

Purpose: Although anaphylaxis is recognized as an important, life-threatening condition, data are limited regarding its triggers in different age groups. We aimed to identify anaphylaxis triggers by age in Korean children. Methods: We performed a retrospective review of medical records for children diagnosed with anaphylaxis between 2009 and 2013 in 23 secondary or tertiary hospitals in South Korea. Results: A total of 991 cases ($mean\;age=5.89{\pm}5.24$) were reported, with 63.9% involving patients younger than 6 years of age and 66% involving male children. Food was the most common anaphylaxis trigger (74.7%), followed by drugs and radiocontrast media (10.7%), idiopathic factors (9.2%), and exercise (3.6%). The most common food allergen was milk (28.4%), followed by egg white (13.6%), walnut (8.0%), wheat (7.2%), buckwheat (6.5%), and peanut (6.2%). Milk and seafood were the most common anaphylaxis triggers in young and older children, respectively. Drug-triggered anaphylaxis was observed more frequently with increasing age, with antibiotics (34.9%) and nonsteroidal anti-inflammatory drugs (17.9%) being the most common causes. Conclusions: The most common anaphylaxis trigger in Korean children was food. Data on these triggers show that their relative frequency may vary by age.

Keywords

Acknowledgement

Grant : BK21플러스

Supported by : 연세대학교

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