Gut and Liver

The Korean Association for the Study of the Liver (대한간학회)
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Prognosis of Pregnancy-Associated Gastric Cancer: An Age-, Sex-, and Stage-Matched Case-Control Study

  • Song, Min Jeong (Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, Young Soo (Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Song, Ho June (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, Se Jeong (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ahn, Ji Yong (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Choi, Kee Don (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Gin Hyug (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jung, Hwoon-Yong (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Yook, Jeong Hwan (Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Byung Sik (Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine)
  • Received : 2015.07.13
  • Accepted : 2015.11.20
  • Published : 2016.09.15
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Abstract

Background/Aims: Pregnancy-associated gastric cancer is a rare condition. This case-control study was performed to identify the clinicopathological features and prognostic factors of pregnancy-associated gastric cancer. Methods: All consecutive patients who presented to our tertiary referral hospital with pregnancy-associated gastric cancer from 1991 to 2012 were identified. Two age-, sex-, and stage-matched controls for each case were also identified from the records. Clinicopathological, gynecological, and oncological outcomes were recorded. Immunohistochemical staining was performed for estrogen receptor, progesterone receptor, epidermal growth factor receptor, human epidermal growth factor receptor, and E-cadherin. Fluorescence in situ hybridization was performed for fibroblast growth factor receptor 2. Results: The median overall survival rates of the pregnancy-associated gastric cancer and control groups were 7.0 months and 15.0 months, respectively (p=0.189). Poor prognostic factors included advanced stage and tumor location in the corpus or the entire stomach but not pregnancy status or loss of E-cadherin. Pregnancy-associated gastric cancer was associated with a longer time from diagnosis to treatment (21 days vs 7 days, p=0.021). The two groups did not differ in the expression of the receptors or E-cadherin. Conclusions: The dismal prognosis of pregnancy-associated gastric cancer may related to the tumor stage and location rather than to pregnancy itself.

Keywords

References

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