Experimental and Molecular Medicine

Korean Society for Biochemistry and Molecular Biongy (생화학분자생물학회)
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Regulation and function of AMPK in physiology and diseases

  • Jeon, Sang-Min (College of Pharmacy and Institute of Pharmaceutical Science and Technology, Ajou University)
  • Received : 2016.04.13
  • Accepted : 2016.04.26
  • Published : 2016.07.31
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Abstract

5'-adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase that was originally identified as the key player in maintaining cellular energy homeostasis. Intensive research over the last decade has identified diverse molecular mechanisms and physiological conditions that regulate the AMPK activity. AMPK regulates diverse metabolic and physiological processes and is dysregulated in major chronic diseases, such as obesity, inflammation, diabetes and cancer. On the basis of its critical roles in physiology and pathology, AMPK is emerging as one of the most promising targets for both the prevention and treatment of these diseases. In this review, we discuss the current understanding of the molecular and physiological regulation of AMPK and its metabolic and physiological functions. In addition, we discuss the mechanisms underlying the versatile roles of AMPK in diabetes and cancer.

Keywords

Acknowledgement

Supported by : Ministry of Health & Welfare, National Research Foundation of Korea (NRF)

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  95. LCAL1 enhances lung cancer survival via inhibiting AMPK-related antitumor functions vol.457, pp.1, 2016, https://doi.org/10.1007/s11010-019-03507-w
  96. Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure vol.25, pp.7, 2016, https://doi.org/10.1111/cns.13116
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  111. Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism vol.10, pp.1, 2019, https://doi.org/10.1038/s41467-019-08938-z
  112. HSP60-regulated Mitochondrial Proteostasis and Protein Translation Promote Tumor Growth of Ovarian Cancer vol.9, pp.1, 2016, https://doi.org/10.1038/s41598-019-48992-7
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  114. Phosphorylation of TET2 by AMPK is indispensable in myogenic differentiation vol.12, pp.None, 2016, https://doi.org/10.1186/s13072-019-0281-x
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  125. The Roles of AMPK in Revascularization vol.2020, pp.None, 2016, https://doi.org/10.1155/2020/4028635
  126. Vanillic Acid Alleviates Acute Myocardial Hypoxia/Reoxygenation Injury by Inhibiting Oxidative Stress vol.2020, pp.None, 2020, https://doi.org/10.1155/2020/8348035
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  130. Ozone Exposure Induces Metabolic Disorders and NAD+ Depletion Through PARP1 Activation in Spinal Cord Neurons vol.7, pp.None, 2020, https://doi.org/10.3389/fmed.2020.617321
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  132. Intracellular Transport in Cancer Metabolic Reprogramming vol.8, pp.None, 2020, https://doi.org/10.3389/fcell.2020.597608
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