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Clinical Outcomes after Modified Fasting Therapy Supplied with Gamrosu: A Retrospective Observational Study

감로수(甘露水)를 이용한 절식요법의 임상결과에 관한 후향적 관찰연구

  • Received : 2016.05.26
  • Accepted : 2016.06.04
  • Published : 2016.06.30

Abstract

Objectives: Two historical evidence supported the concept of Gamrosu. The first one was Jeho-tang, a selected thirst quencher in Chosun Dynasty and the second one was Saeng-Maek-san, Dongeuibogam's recommendation as one of the qi-vigorating summer beverages. Gamrosu is a modified fasting therapy beverage which is manufactured from those two prescriptions and the carbohydrates (420.6 kcal/d). A retrospective observational study was conducted to evaluate the clinical outcomes. Methods: Thirty-three cases were reviewed at three local Korean Medical clinics that each site's participant has finished the modified fasting for 10 consecutive days. Clinical outcomes were reviewed at pre- and post-fasting sessions by retrieving the changes of body composition, blood pressure, blood chemistries & urine tests, and subjective symptoms & fatigue scores. Results: Demographics of the observed participants were 17 of male and 16 of female. Post-Gamrosu session, -6.89% of body weight, -8.97% of body fat mass were reduced with the nutrition indices being improved (P<0.001). -8.72% of systolic blood pressure, -39.86% of serum triglyceride, -6.75% of fast blood sugar and -8.12% of waist circumference were improved (P<0.05). The levels of high sensitivity C-reactive protein (-58.34%), CRP (-43.55%) and eosinophil (-21.30%) showed the significant diminished profiles (P<0.05). Liver/kidney functions and the standard of electrolytes were maintained within normal range in stable manners. The fatigue scale scores indicated significant lower scores. Conclusions: Taken together, obesity-related clinical outcomes after a modified fasting therapy with Gamrosu were sufficiently feasible and the observed findings should be considered for further prospective clinical studies.

Keywords

References

  1. Yoon YH, Yun CY. A study on thought of regimen specified in Gyeokchiyeoron. J Korean Med Class. 2014 ; 27(4) : 153-69. https://doi.org/10.14369/SKMC.2014.27.4.153
  2. Heilbronn LK, Ravussin E. Calorie restriction and aging: review of the literature and implications for studies in humans. Am J Clin Nutr. 2003 ; 78(3) : 361-9. https://doi.org/10.1093/ajcn/78.3.361
  3. Michalsen A, Li C. Fasting therapy for treating and preventing disease-current state of evidence. Forsch Komplementmed. 2013 ; 20(6) : 444-53. https://doi.org/10.1159/000357765
  4. Wilhelmi de Toledo F, Buchinger A, Burggrabe H, Holz G, Kuhn C, Lischka E, et al. Fasting therapy: an expert panel update of the 2002 consensus guidelines. Forsch Komplementmed. 2013 ; 20(6) : 434-43. https://doi.org/10.1159/000357602
  5. Korean Association of Oriental Rehabilitation Medicine. Text book of oriental rehabilitation medicine. 2nd ed. Seoul : Koonja Publisher. 2005 : 376-84.
  6. Shin SU, Kim SS, Shin HD. The clinical study on the effect of reduction in body weight and the change of body composition after fasting therapy. J Korean Med Obes Res. 2003 ; 3(1) : 25-35.
  7. Kim KW, Chung SH, Chung WS. Clinical case series on the changes of body composition and blood chemistry after modified fasting therapy: a retrospective observational study. Master's thesis. Seoul: Kyunghee University. 2013.
  8. Park WI, Lee JH, Jo SH, Paik BL, Choi CK, Lee SG, et al. Effect of a traditional Korean very-low-calorie diet on obese patients. Korean J Med. 2002 ; 62(3) : 250-7.
  9. Hwang EH, Kim JY. The clinical study of comparison efficacy between the vegetable ferment extract and the spring water in fasting therapy. J Orient Rehab Med. 2004 ; 14(2) : 119-28.
  10. Nho JS. Very low calorie diet combining fasting with juice for obese patients. Master's thesis. Seoul: Kyunghee University. 2014.
  11. Kim DB, Chang SK, Cho CS, Kim CJ. The effect of zymolysis-dietotherapy with herbal formula on the obesity. Daejeon Univ Inst Korean Med. 2008 ; 17(1) : 75-82.
  12. Rothacker DQ, Staniszewski BA, Ellis PK. Liquid meal replacement vs traditional food: a potential model for women who cannot maintain eating habit change. J Am Diet Assoc. 2001 ; 101(3) : 345-7. https://doi.org/10.1016/S0002-8223(01)00089-X
  13. Lee JM, Hong SY. Effects of modified fasting therapy using fermented herbal medicine on changes of body compositions. J Orient Rehab Med. 2011 ; 21(3) : 33-43.
  14. Oh DS, Kim DH, Shin HT, Shin SU. A pilot study to develop beverage Gamrosu, a modified fasting therapy: case series, J Korean Med Obes Res. 2015 ; 15(2) : 153-61. https://doi.org/10.15429/jkomor.2015.15.2.153
  15. Lee SB, Keum DH, Lee MJ. The clinical study on protein analysis during fasting therapy period. J Orient Rehab Med. 1996 ; 6(1) : 317-26.
  16. Kim KW, Chung WS, Chung SH. A clinical case study on the changes of body composition and blood chemistry after modified fasting therapy in a patient with obesity. J Korean Med Obes Res. 2010 ; 10(2) : 49-56.
  17. Chung WS, Park HK, Choi HJ, Kim SS. A case report on the jaundice occurred during the modified fasting therapy period: the Gilbert's syndrome. J Korean Med Obes Res. 2011 ; 11 : 69-74.
  18. Jung SK, Kim DE, Yu DS, Yeom SR, Song YS, Kwon YD. The retrospective study on modified fasting therapy in inpatients. J Orient Rehab Med. 2008 ; 18(4) : 171-87.
  19. Kwon YY, Song YS. The clinical studies on obesity by fasting therapy. J Orient Rehab Med. 1995 ; 5(1) : 225-60.
  20. An JW, Choi SW, Kim JY. A clinical study on the body composition changes after fasting therapy. J Orientl Rehab Med. 2001 ; 11(1) : 29-43.
  21. Yeom SR, Kwon YD, Shin BC, Song YS, Lee JD. The clinical study on the change of bone mineral density during fasting therapy. J Orient Rehab Med. 2001 ; 11(2) : 27-37.
  22. Ji MS, Park MJ, Lee MY, Kim JG, Ko BS. Effect of Jehotang extract on the growth of intestinal bacteria and immunostimulation. Korean J Food Sci Technol. 2006 ; 38(1) : 104-8.
  23. Jeong SH, Kim SI, Sim KH, Jin SY, Kim MH. Antioxidant and antidiabetic activity of Jehotang according to different cooking methods. Culi Sci Hos Res. 2012 ; 18(5) : 233-42.
  24. Park KJ, Lee MJ, Kang HM, Kim KS, Lee SH, Cho IH. Saeng-Maek-San, a medicinal herb complex, protects liver cell damage induced by alcohol. Biol Pharm Bull. 2002 ; 25(11) : 1451-5. https://doi.org/10.1248/bpb.25.1451
  25. Ju IH. Effects of Saengmaek-san on osteoclastogenesis and gene expression. Master's thesis. Iksam: Wonkwang university. 2013.
  26. Lee SY, Oh SW. As a predictor of cardiovascular disease risk factors, body mass index and waist circumference usefulness: comparison between countries. Korean J Health Promot Dis Pre. 2005 ; 5(2) : 97-113.
  27. Goldhamer A, Lisle D, Parpia B, Anderson SV, Campbell TC. Medically supervised water-only fasting in the treatment of hypertension. J Manipulative Physiol Ther. 2001 ; 24(5) : 335-9. https://doi.org/10.1067/mmt.2001.115263
  28. Cho SI, Song YM, Kim CH, Seo HK, Choi JH, Shin BM. The effect of the fasting on body weight, blood pressure, blood cell count and blood chemistry in people. J Korean Acad Fam Med. 1994 ; 15(12) : 1128-40.
  29. Ryu EK, Chung SH, Lee JS, Kim SS, Shin HD. Clinical studies on hematologic change by fasting therapy. J Korean Med. 1989 ; 10(1) : 148-53.
  30. The Korean Association of Internal Medicine. Harrison's internal medicine. Seoul : MIP. 2003 : 460, 763, 1764.
  31. Kim BH. Diagnostic approach to abnormal liver tests in apparently healthy subjects. J Korean Med Assoc. 2005 ; 48(5) : 414-22. https://doi.org/10.5124/jkma.2005.48.5.414
  32. Samra M, Abcar AC. False estimates of elevated creatinine. The Perm J. 2012 ; 16(2) : 51-2.
  33. Watts NB, DiGirolamo M. Carbohydrate tolerance improves with fasting in obese subjects with noninsulin-dependent (type II) diabetes. Am J Med Sci. 1990 ; 299(4) : 250-6. https://doi.org/10.1097/00000441-199004000-00006
  34. Kang HJ, Song YS. Dietary fiber and cholesterol metabolism. J Korean Soc Food Sci Nutr. 1997 ; 26(2) : 358-69.
  35. Savendahl L, Underwood LE. Fasting increases serum total cholesterol, LDL cholesterol and apolipoprotein b in healthy, nonobese humans. J Nutr. 1999 ; 129(11) : 2005-8. https://doi.org/10.1093/jn/129.11.2005
  36. Min WK, Park HI, Jun KR, Chun SI, Lee WC. Factors affecting the difference between the low-density lipoprotein cholesterol concentrations measured directly and calculated using the friedewald formula. J Lab Med Qual Assur. 2008 ; 30(2) : 233-5.
  37. Park JS, Kim YJ, Lee JG, Kim YJ, Lee SL, Min HG, et al. The role of C-reactive protein as a inflammation-related factor in metabolic syndrome. Korean J Fam Med. 2009 ; 30(6) : 449-56. https://doi.org/10.4082/kjfm.2009.30.6.449
  38. Son JC, Kim BT, Lee DJ, Choi HK, Chung HJ, Kim GM. The most associated risk factor of the metabolic syndrome with C-reactive protein. Korean J Obes. 2003 ; 12(1) : 15-23.
  39. Lim KH. Metabolic adaptation to starvation. Inje Med J. 1999 ; 20(1) : 197-208.
  40. Edwards C, Canfield J, Copes N, Rehan M, Lipps D, Bradshaw PC. D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging(Albany NY). 2014 ; 6(8) : 621-44.
  41. Jing MJ, Lin WQ, Wang Q, Wang JJ, Tang J, Jiang ES, et al. Reliability and construct validity of two versions of Chalder Fatigue Scale among the general population in mainland China. Int J Environ Res Public Health. 2016 ; 13(1) : 147. https://doi.org/10.3390/ijerph13010147

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