The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지
DOI QR코드

DOI QR Code

Deficiency-excess and Cold-heat Pattern Identification and Analysis of the Characteristics of Asthma Patients

천식(喘息) 환자의 허실한열변증(虛實寒熱辨證)과 특성 비교 분석

  • Bhang, Yeon-hee (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Jae-hyo (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Do, Ha-yoon (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Mi-a (Kyung Hee University Korean Medicine Hospital) ;
  • Kim, Kwan-il (Kyung Hee University Korean Medicine Hospital) ;
  • Lee, Beom-joon (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Jung, Hee-jae (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
  • 방연희 (경희대학교 대학원 임상한의학과 폐계내과학교실) ;
  • 김재효 (경희대학교 대학원 임상한의학과 폐계내과학교실) ;
  • 도하윤 (경희대학교 대학원 임상한의학과 폐계내과학교실) ;
  • 김미아 (경희대학교 한방병원) ;
  • 김관일 (경희대학교 한방병원) ;
  • 이범준 (경희대학교 대학원 임상한의학과 폐계내과학교실) ;
  • 정희재 (경희대학교 대학원 임상한의학과 폐계내과학교실)
  • Received : 2017.11.24
  • Accepted : 2017.12.29
  • Published : 2017.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: The aim of this observational study was to identify and analyze the patterns to compare the characteristics of asthma patients. Methods: The subjects were 40 asthma patients who had satisfied the inclusion and exclusion criteria. They were divided into deficiency syndrome and excess syndrome groups, and cold syndrome and heat syndrome groups. Their quality of life was measured by the quality of life questionnaire for adult Korean asthmatics (QLQAKA) and VAS. Heart rate variability (HRV) was measured, and the degree of obesity was evaluated by body mass index (BMI). Hematological, biochemical, and immunoglobulin (Ig) E laboratory tests were included. Results: Based on pattern identification, the 40 asthma patients could be divided into two categories of groups: 1) the deficiency syndrome (N=18) and the excess syndrome (N=22) groups: 2) the cold syndrome (N=35) and the heat syndrome (N=5) groups. The mean value of HF differed significantly between the deficiency and excess syndrome groups. The mean value of IgE in blood tests of asthmatics was greater than four times the reference value. For BMI, the subjects were classified into three groups: normal weight (N=12), overweight (N=12), and obese (N=16). Conclusions: Development of a more accurate asthma-specific pattern identification tool could play a crucial role in asthma control. In addition, good control of asthma can improve the quality of life. Obesity is one of the factors associated with asthma exacerbation.

Keywords

References

  1. The Korean Academy of Tuberculosis and Respiratory diseases. Respiratory Diseases. Seoul: Koonja; 2007, p. 325-6.
  2. Masoli M, Fabian D, Holt S. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59:469. https://doi.org/10.1111/j.1398-9995.2004.00526.x
  3. Korean Academy of Asthma, Allergy, and Clinical Immunology, Korean Academy of Allergy and Respiratory Disease. Korean guideline for asthma. Korean Academy of Asthma, Allergy, and Clinical Immunology, Korean Academy of Allergy and Respiratory Disease, c2016. [cited 2016 Mar 20]. Available from: http://www.allergy.or.kr/file/150527_01.pdf.
  4. Hwang WS, Lee JS, Joo CY, Jung HJ, Lee HG, Jung SK. The Clinical Study on 1 Case of Hyperthyroid patient Treated with Yukmijihwangtang. The Journal of Oriental Chronic Diseases 2002; 8(1):53-63.
  5. He DP, Wang WL, Guo QJ. Literature Study on Distribution Regularity of Traditional Chinese Medicine Syndromes of Bronchial Asthma. J of Liaoning University of Traditional Chinese Medicine 2010;12(8):71-2.
  6. Gan HJ. Studies on Relationship Between Cold-heat Asthma at Stage of Attack of Bronchial Asthma and ET-1 and ANF. J of Shaanxi College of Traditional Chinese Medicine 2003;26(5):64-6.
  7. Li ZY, Liu WW. Clinical Study on Immunity, Adrenocortical Function and Platelet Activation in Cold-Heat Type of Attack Stage of Child Asthma. J of Fujian College of Traditional Chinese Medicine 2001;11(1):6-9.
  8. Cao YX, Dong JC, Du YJ. Biomarkers and Inflammatory Characteristics for Microcosmic Syndrome Differentiation of Cold-phlegm Syndrome and Heat-phlegm Syndrome in Patients with Bronchial Asthma. Zhongguo Zhong Xi Yi Jie He Za Zhi 2010;30(8):828-32.
  9. Kim SK, Park YB. Development of Questionnaire for Cold-Heat Patternization. Journal of korean Institute of Oriental Medical Diagnostics 2003; 7(1):64-75.
  10. Park JW, Cho YS, Lee SY, Nahm DH, Kim YK, Kim DK, et al. Multi - center study for the utilization of quality of life questionnaire for adult Korean asthmatics (QLQAKA). Journal of asthma, allergy and clinical immunology 2000; 20(3):467-79.
  11. Ahn JE, Yoo KY. Statistic Analysis of Biomedical Data. Seoul: Hannarae; 2006, p. 261-423.
  12. The Global Initiative for Asthma. GINA report, global strategy for asthma management and prevention. Revised 2016 [Internet]. The Global Initiative for Asthma; c2016 [cited 2016 Mar 26]. Available from: http://www.ucalgary.ca/icancontrolasthma/files/icancontrolasthma/wms-gina-2016-main-report-final.pdf.
  13. Song WJ, Kang MG, Chang YS, Cho SH. Epidemiology of Adult Asthma in Asia: toward a better understanding. Asia Pac Allergy 2014; 4(2):75-85. https://doi.org/10.5415/apallergy.2014.4.2.75
  14. Lee BK. Korean Diagnostics. Seoul: Sungbosa; 2009, p. 25, 42.
  15. The National University of Dept. of Internal Medicine Pulmonary System. Internal Medicine Pulmonary System. Seoul: Nado; 2010, p. 491.
  16. Lee SI, Kim DG, Lee YJ, No SH, Joo YS. Herbal Formula Science. Seoul: Younglimsa; 1999, p. 50-2.
  17. Jang GB. Kyungakjeonseo. Seoul: Iljungsa; 1992, p. 354-64.
  18. Jung DY, Lee JH, Jung SK, Lee HG. Literature reviews on asthma due to dyspnea due to the kidney deficiency. Journal of Korean Medicine 1978;15(1):498-504.
  19. Choi JY, Lee JS, Jeong SY, Lee KY, Lee KK, Jung HJ, et al. An Analysis of Therapeutic Effects of Gamichuongsangboha-tang in 30 Asthmatics Based on Criteria for Defiency-Excess Differentiating Syndromes of Asthma. The Journal of Internal Korean Medicine 2004;25(3):379-87.
  20. Yeo MK, Park KH, Bae KH, Jang ES, Lee YS. Development on the Questionnaire of Cold-Heat Pattern Identification Based on Usual Symptoms for Health Promotion - Focused on Reliability Study. J Physiol & Pathol Korean Med 2016; 30(2):116-23. https://doi.org/10.15188/kjopp.2016.04.30.2.116
  21. The National Univerity of Dept. of Oriental Medical Diagnostics, Biofunction. Biofunctional Medicine. Seoul: Koonja; 2008, p. 81, 94-6.
  22. Jung IT, Lee SH, Kim SY, Cha NH, Kim KS, Lee DI, et al. The Effect of Acupuncture Treatment on the Heart Rate Variability of Chronic Headache Patients. The journal of Korean Acupuncture & Moxibustion Society 2005;22(3):105-12.
  23. Kim JS, Hwang W, Bae KT, Nam SS, Kim YS. Effect of Acupuncture for Mental Stress on Short-term Analysis of Heart Rate Variability (HRV). Journal of Korean Acupuncture & Moxibustion Society 2004;21(5):227-39.
  24. Min YG. The Pathophysiology, Diagnosis and Treatment of Allergic Rhinitis. Allergy Asthma Immunol Res 2010;2(2):65-76. https://doi.org/10.4168/aair.2010.2.2.65
  25. Kim SH, Go HG, Gang YJ, Sung YE, Park IW, Choi BH. The effect of inhaled disodium cromoglycate on the blood eosinophil count and serum IgE level in stable bronchial asthmatics. Journal of asthma, allergy and chinical immunology 1995;15(2):230-8.
  26. Beuther DA, Sutherland ER. Overweight, Obesity, and Incident Asthma: a Meta-Analysis of Prospective Epidemiologic Studies. Am J Respir Crit Care Med 2007;175(7):661-6. https://doi.org/10.1164/rccm.200611-1717OC
  27. Ronmark E, Andersson C, Nystrom L, Forsberg B, Jarvholm B, Lundback B. Obesity Increases the Risk of Incident Asthma among Adults. Eur Respir J 2005;25(2):282-8. https://doi.org/10.1183/09031936.05.00054304
  28. Peters JI, McKinney JM, Smith B, Wood P, Forkner E, Galbreath AD. Impact of obesity in asthma: evidence from a large prospective disease management study. Ann Allergy Asthma Immunol 2011;106(1):30-5. https://doi.org/10.1016/j.anai.2010.10.015
  29. Choi JE, Shin TR, Park SM, Kim JH, Shin SH, Lee HY, et al. Association of Body Mass Index with Airway Hyperresponsiveness and Lung Function in Adult Asthmatics. Allergy Asthma Respir Dis 2014;2(1):16-22. https://doi.org/10.4168/aard.2014.2.1.16

Cited by

  1. 천식환자 허실변증과 객담 cytokine 및 특성 비교분석 vol.40, pp.4, 2019, https://doi.org/10.22246/jikm.2019.40.4.582