The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
권호 표지
DOI QR코드

DOI QR Code

Research Trends of the Traditional Korean Medicine Treatment for Atopic Dermatitis -Based on the Journal of Pediatrics of Korean Medicine-

아토피 피부염의 한의학적 치료에 대한 연구 동향 -대한한방소아과학회지를 중심으로-

  • Jin, Qi Ying (Department of Korean Pediatrics, Graduate School, Kyung Hee University) ;
  • Lee, Jin Yong (Department of Korean Pediatrics, Graduate School, Kyung Hee University)
  • 김기영 (경희대학교 대학원 소아과학교실) ;
  • 이진용 (경희대학교 대학원 소아과학교실)
  • Received : 2016.11.28
  • Accepted : 2017.02.13
  • Published : 2017.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives The goal of this review was to investigate clinical, experimental and literature studies of Korean medicine on atopic dermatitis (AD) of Korean children in Korean medicine literature, seeking for the better research methods for more effective treatments. Methods Electronic investigations were practiced on AKOP (The Association of Korean Oriental Pediatrics, http://www.akop.or.kr) to collect theses which were published by J Pediatr Korean Med. The key word 'Atopy' was used for searching to ensure that every related thesis was collected. The publication date was limited from 1996 to 2016. The selected literatures were assessed mainly according to distributions of study type, publication year, scale, treatment and its efficacy. Results 55 papers were selected from 59 studies. In these collected 55 related theses, there were 29 experimental studies (52.73%), 18 clinical studies (32.73%), 8 review studies (14.55%). In the 29 experimental studies, there were 20 studies (68.97%) using NC/Nga mouse as subjects. The mite antigen was used to trigger AD by 8 studies (27.59%). The studies have been utilizing DNCB and DNFB instead of mite antigen since 2011. All the experimental studies showed that the Korean medicine was effective in AD. In total 18 clinical studies, 3 studies (16.67%) were case reports, only 1 thesis (5.56%) was conducted by case control study and the rest were case series studies. 7 studies (38.89%) of 18 studies diagnosed AD according to Hanifin and Rajka's diagnostic criteria (1980), only 1 study (5.56%) according to the Korean standard and the rest 10 studies (55.56%) didn't mention diagnostic criteria. 12 clinical studies (66.67%) showed efficacy in treating AD. There were 10 studies (55.56%) only employing internal treatments and 1 thesis (5.56%) didn't mention the exact prescription. Naesowhajungtang-kamibang, Saenghyeoryunbue-um were used 3 times (16.67%) as the internal medicine respectively. 5 theses (27.78%) were combined with acupuncture therapy. Hegu (LI4), Sanyinjiao (SP6) were used in 4 theses, and Taichong (LR3), Quchi (LI11), Zusanli (ST36) in 3 theses. The number of acupoints chosen from The Spleen meridian of Foot-Taiyin was the largest. There were 8 review theses. 2 were about the foreign oriental medicine, 3 were about the external medicine or external treatment methods, and 3 other studies were about severity scoring systems, the methodological study in the latest clinical study, overview for pattern and results of herbal medicine-derived AD clinical researches. Conclusions The experimental studies and clinical studies showed the effectiveness of Korean medicine treatments. However, this study still needs improving by conducting more comparative studies and using better research methods, in order to find more effective treatments to improve clinical efficacy.

Keywords

References

  1. Lee HS, Kim JS, Pyun BY. Pediatric allergy and respiratory disease, change of prevalence and the allergens of atopic dermatitis in children: in between the year of 1992 and 2002. Pediatr Allergy Respir Dis. 2002;12(4):263-71.
  2. Korean Dermatological Association Textbook Compilation Committee. Dermatology. 5th ed. Seoul: Ryomoongak Publishing co. 2008:170.
  3. Hong WS. Jeonggyo Huang Di Nei Jing Su Wen. Seoul: Dongyanguihakyeonguwon Publishing co. 1985:72-80, 246-8.
  4. Song SG. Jin Gui Yao Lue Guang Zhou Xiao Quan. Beijing: Renminweisheng Publishing co. 1994:221-6.
  5. Chao YF. Chao Shi Zhu Bing Yuan Hou Lun. Seoul: Daesung Publishing co. 1992:251-3.
  6. Kwon MW, Lee HJ, Park EJ, Hwang WJ. The clinical study of atopic dermatitis and eosinophil cationic protein in atopic dermatitis. J Korean Orient Med. 2000;14(2):121-32.
  7. Choi YY, Kim MH, Kim CJ, Choi YJ, Hwang MK. Anti-inflammatory effects of HC001 on atopic dermatitis- like skin lesions in mice. J Korean Orient Med Prescription. 2012;20(1):41-9.
  8. Choi IH, Kim SH, Kim YC, Yun YH. A clinical study of Shi Ho Cheong Gan-San on Blood Heat pattern atopic dermatitis: a randomized, double-blind clinical trial. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 2011;24(1):96-110.
  9. Choi H, Kim JS, Lee EH. Clinical study for visual application of circle pattern with 3G color on atopic dermatitis patients. J Korean Orient Pediatr. 2009;23(2):1-14.
  10. Lee SH, Chang GT, Kim JH. A study on growth of children with atopic dermatitis. J Korean Orient Pediatr. 2002;16(2):163-70.
  11. Kwon WM, Lee JL, Park EJ, Hwang WJ. The clinical study of atopic dermatitis and eosinophil cationic protein in atopic dermatitis. J Korean Orient Med. 2000;14(2):119-30.
  12. Kim MJ, Kim DG, Lee JY. The relationship between allergic and functional gastrointestinal disorders in children and adolescents. J Pediatr Korean Med. 2014;28(1):32-42. https://doi.org/10.7778/jpkm.2014.28.1.032
  13. Lee JH, Han JK, Kim YH. The effects of Forsythiae Fructus n-BuOH fraction on atopic dermatitis. J Korean Orient Pediatr. 2016;30(3):1-30.
  14. Aum SH, Ahn SH, Park SY, Cheon JH, Kim KB. The anti-inflammatory effects of Hataedock taken Douchi extracts on atopic dermatitis-like skin lesion of NC/Nga mouse. J Korean Orient Pediatr. 2016;30(2):1-9.
  15. Cha HY, Ahn SH, Jeong AR, Cheon JH, Park SY, Kim KB. The effects of Hataedock on 2,4-dinitrofluorobenzene induced atopic dermatitis like skin lesion in NC/Nga mice. J Korean Orient Pediatr. 2015;29(4):97-107. https://doi.org/10.7778/jpkm.2015.29.4.097
  16. Kim YH, Lee HL. Therapeutic effects of Sesamum Indicum extracts on atopic dermatitis-like skin lesions of NC/Nga mouce. J Korean Orient Pediatr. 2015;29(4):39-66. https://doi.org/10.7778/jpkm.2015.29.4.039
  17. Park JM, Chae JW. Effects of Aurantii Immaturus Fructus (AI) on atopic dermatitis (AD) induced by DNCB in mice. J Korean Orient Pediatr. 2015;29(1):27-43. https://doi.org/10.7778/jpkm.2015.29.1.027
  18. Lee YS, Han JK, Kim YH. The effects of Dictamni Radicis Cortex extracts on DNCB induced atopic dermatitis- like skin lesions of NC/Nga mouse. J Korean Orient Pediatr. 2014;28(4):1-29.
  19. Min DL, Park EJ. Effects of Nardostachys Jatamansi on atopic dermatitis-like skin lesions. J Korean Orient Pediatr. 2012;26(2):13-24. https://doi.org/10.7778/jpkm.2012.26.2.013
  20. Seo HY, Han JK, Kim YH. Therapeutic effects of Yijungtang on atopic dermatitis-like skin lesions of NC/Nga mouse induced by mite antigen. J Korean Orient Pediatr. 2011;25(1):1-27.
  21. Han DS, Han JK, Kim YH. Effects of SPDJTK (SoPungDoJeokTangKami) and concurrent administration of AJ (Atopy cream, Jawoongo) plus SPDJTK on atopic dermatitis-like skin lesions in NC/Nga mouse induced by BMAC. J Korean Orient Pediatr. 2010;24(1):9-35.
  22. Park DB, Han JK, Kim YH. Effect of Yanghyeoljeseuptang (YHJST) composition on atopic dermatitis NC/Nga mice induced by DNCB (dinitrochlorobenzene). J Korean Orient Pediatr. 2009;23(3):263-91.
  23. Lee NY, Kim YH, Han JK. Effects of concurrent administration of Jaumjeseuptangkakam (JUJSTK) and atopy cream, Jawoongo (AJ) on atopic dermatitis-like skin lesions in NC/Nga mouse. J Korean Orient Pediatr. 2009;23(2):9-36.
  24. Park SK, Han JK, Kim YH. Anti-dermatitis effects of Kamicheongsimyeonjatang on GATA-3 regulation in NC/Nga mouse. J Korean Orient Pediatr. 2009;23(2):29-50.
  25. Song HJ, Han JK, Kim YH. Effects of concurrent administration of KKSDU and AJ on atopic dermatitis-like skin lesions in NC/Nga mouse. J Korean Orient Pediatr. 2009;23(2):51-85.
  26. Lee NY, Kim YH, Han JK. Effects of Jaumjeseuptangkakam (JUJSTK) on atopic dermatitis-like skin lesions in NC/Nga mouse. J Korean Orient Pediatr. 2009;23(2):87-101.
  27. Song HJ, Han JK, Kim YH. Effects of Kakamsodokum (KKSDU) on atopic dermatitis-like skin lesions in NC/Nga mouse. J Korean Orient Pediatr. 2009;23(1):23-35.
  28. Yeo EJ, Han JK, Kim YH. Effects of atopy cream-combined with Jawoongo ointment on the development of atopic dermatitis-like skin lesions in NC/Nga mouse. J Korean Orient Pediatr. 2009;23(1):37-72.
  29. Yoon JE, Kim YH, Han JK, Kim YH. Effect of Gupoongjeseuptang (GPJST) on DNCB (dinitrochloro benzene)-induced atopic dermatitis-like model NC/Nga mice. J Korean Orient Pediatr. 2008;22(3):105-37.
  30. Na DG, Han JK, Kim YH. Effect of Jeseupwiryeongtang-gagam on atopic dermatitis-like skin NC/Nga mouse induced by Dermatophagoides Farinae Crude extract. J Korean Orient Pediatr. 2008;22(2):81-114.
  31. Kim YH, Han JK, Kim YH. Effect of Kami-kanghwalsan (KKHS) on atopic dermatitis-like skin lesions induced in NC/Nga mouse by mite antigen stimulation. J Korean Orient Pediatr. 2008;22(1):69-93.
  32. Yeo EJ, Han JK, Kim YH. Inhibitory studies of Scrophulariae Radix on development of dermatitis in NC/Nga mice. J Korean Orient Pediatr. 2007;21(2):13-34.
  33. Kim WY, Lee JY. Effects of Hanghaedan on the cytokine secretory function of monocytes of atopic dermatitis patients. J Korean Orient Pediatr. 2007;21(2):169-84.
  34. Yoon JY, Han JK, Kim YH. Effect of Kami-chungsimyeunjatang on atopic dermatitis-like skin lesions induced in NC/Nga mice by mite antigen stimulation. J Korean Orient Pediatr. 2007;21(1):87-116.
  35. Kim HB, Kim OI, Lee SY. Anti-histamic effect and IL-4 and GM-CSF mRNA expression on Sungmagalkuntang. J Korean Orient Pediatr. 2006;20(2):69-83.
  36. Han KH, Park EJ, Lee HJ. A comparative study of regulatory effect of atopic allergic reaction by prescriptions (A, B). J Korean Orient Pediatr. 2005;19(2):13-30.
  37. Han JK, Kim YH. Effect of Kami-dangkueeumja (KDKEJ) in atopic dermatitis animal model. J Korean Orient Pediatr. 2005;19(1):35-52.
  38. Jin KS, Lim TH, Park EJ, Lee HJ, Han KH, Na WK. Regulatory effect of atopic allergic reaction by Chungsangbangpoong-tang. J Korean Orient Pediatr. 2004;18(2):61-76.
  39. Han KC, Lee JY, Kim DG. Effects of Arctii Fructus on the atopic dermatitis. J Korean Orient Pediatr. 2004;18(2):107-17.
  40. Kim SH, Jung HS, Cho BG, Lee JY, Kim DG. Effects of Lithospermum Erythrorhizon on the atopic dermatitis. J Korean Orient Pediatr. 2004;18(1):63-75.
  41. Shin DG, Kim WY, Lee JY, Kim DK. Effect of Sunbangpaedoktang on the cytokine secretory function of monocyte isolated and cultured from peripheral blood of AD patients. J Korean Orient Pediatr. 2002;16(1):21-37.
  42. Park JW, Park CK. A statistical study on the contents of theses of oriental medicine. J Korean Med Classics. 1994;7:161-97.
  43. Sung HK, Seo KS, Son CG. A observational study on children with atopic dermatitis in atopic-free village. J Korean Orient Pediatr. 2014;30(2):1-9.
  44. Jo MS, Han JK, Kim YH. The use of oriental medicine for pediatric outpatients with atopic dermatitis. J Korean Orient Pediatr. 2011;25(2):8-15. https://doi.org/10.7778/jpkm.2011.25.2.008
  45. Shin MR, Oh JA, Lee DN. 6 cases of atopic dermatitis children patients for hospitalization program. J Korean Orient Pediatr. 2014;28(2):40-55. https://doi.org/10.7778/jpkm.2014.28.2.040
  46. Min DL, Han MH, Park G, Seo S, Han SR. Retrospective study about the effectiveness of a Korean medicine treatment on 69 infant and young child atopic dermatitis patients. J Korean Orient Pediatr. 2014;28(3):17-30. https://doi.org/10.7778/jpkm.2014.28.3.017
  47. Ko MJ, Baek JH. A clinical study on the effect of Hwangryunhaedock-tang on atopic dermatitis. J Korean Orient Pediatr. 2012;26(4):51-60. https://doi.org/10.7778/jpkm.2012.26.4.051
  48. Park ES, Lee JY. One case of atopic dermatitis treated by Horminis Placenta external wet therapy. J Korean Orient Pediatr. 2010;24(1):46-56.
  49. Yoon HJ, Yoon JS, Kim DG, Lee JY. The effects of low level laser therapy on decrease of atopic dermatitis symptoms. J Korean Orient Pediatr. 2009;23(3):193-206.
  50. Yu HY, Kim KB, Min SY, Kim JH. Case study of the effects of Saenghyeoryunbueum on atopic dermatitis. J Korean Orient Pediatr. 2008;22(1):35-48.
  51. Song HJ, Han JK, Kim YH. A clinical study on the treatment of atopic dermatitis by using Kamichungsimyeunjatang. J Korean Orient Pediatr. 2007;21(3):21-31.
  52. You HJ, Lee JY, Kim DG. Effects of Naesowhajungtanggamibang on serum cytokines of patients with atopic dermatitis. J Korean Orient Pediatr. 2006;20(2):15-29.
  53. Koh DJ, Yoo HJ, Lee JY, Kim DG. Clinical assessment of efficacy, safety and usefulness of traditional herbal medicine (THM) on atopic dermatitis. J Korean Orient Pediatr. 2006;20(2):129-37.
  54. Lim YK, Jung JA, Yun CS, Hur KW, Lee H, Kim HC, Kim YR, Cho YH. A pilot study of herb medication for atopic dermatitis. J Korean Orient Pediatr. 2006;20(3):129-41.
  55. Cho BG, Lee JY, Kim DG. A clinical study on the treatment of atopic dermatitis using Naesowhajungtanggamibang. J Korean Orient Pediatr. 2005;19(1):131-41.
  56. Kim DG, Lee JY. The clinical study of atopic dermatitis. J Korean Orient Pediatr. 1999;13(2):171-86.
  57. Lee SH, Kim JH. The clinical study of atopic dermatitis treated by Bopejungcheuntang (BPJC). J Korean Orient Pediatr. 2000;14(1):137-52.
  58. Jung HS, Lee JY. A study on the alteration of general characteristics and therapeutic effect of Gamiyeoldahansotang (加味熱多寒少湯) in patients with atopic dermatitis. J Korean Orient Pediatr. 2001;15(2):177-88.
  59. Han JK, Kim YH. A clinical study in 20 cases of atopic dermatitis (treatment with aroma therapy and Jaungo). J Korean Orient Pediatr. 2001;15(1):15-37.
  60. Jang JH, Lee JM, Lee SY. A clinical study of atopic dermatitis for children. J Korean Orient Pediatr. 2005;19(2):69-84.
  61. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl. 1980;92:44-7.
  62. Park YL, Kim HD, Kim KH, Kim MN, Kim JW, Ro YS, Park CW, Lee KH, Lee AY, Cho SH, Choi JH. Report from ADRG: a study on the diagnostic criteria of Korean atopic dermatitis. Korean J Dermatol. 2006;44(6):659-63.
  63. Park BK, Jang GT, Kim JH. A study of external treatment for the atopic dermatitis. J Korean Orient Pediatr. 2003;17(1):71-86.
  64. Kim MJ, Lee SY. A literature study of atopic dermatitis for children. J Korean Orient Pediatr. 2000;14(2):167-82.
  65. Min DL, Park EJ, Kang KH. Review of clinical and experimental studies on external application treatment for atopic dermatitis in the Korean literature. J Korean Orient Pediatr. 2013;27(1):36-49. https://doi.org/10.7778/jpkm.2013.27.1.036
  66. Ha NR, Lee JC, Kim KB. Recent research on treatments of atopic dermatitis in Japan -within diet and Kampo medicine-. J Korean Orient Pediatr. 2012;26(1):16-35. https://doi.org/10.7778/jpkm.2012.26.1.016
  67. Seo JM, Kim SC, Hwang SY, Hwang BM, Lee SY, Lee SG, Baek JH. A study on the severity scoring systems of atopic dermatitis; comparison, analysis and establishment on childhood patients in oriental medicine. J Korean Orient Pediatr. 2006:20(2):1-14.
  68. Kim KB, Min SY, Kim JH. The methodological study on atopic dermatitis in the latest clinical study. J Korean Orient Pediatr. 2006;20(2):151-64.
  69. Kim YH. Overview for pattern and results of herbal medicine-derived atopic dermatitis clinical researches. J Korean Orient Pediatr. 2012;26(2):53-61. https://doi.org/10.7778/jpkm.2012.26.2.053
  70. Park JS, Kim YH. A study on the dietary and external treatments of atopic dermatitis, and it's application according to phisical type. J Korean Orient Pediatr. 2003;17(2):85-101.

Cited by

  1. CARE 지침에 따른 대한한방소아과학회지의 증례보고에 대한 질평가 vol.32, pp.3, 2017, https://doi.org/10.7778/jpkm.2018.32.3.131
  2. 한방치료를 통한 성인 전신성 아토피 피부염 치험 1례 - 오령산(五苓散) 사용 효과를 중점으로 vol.32, pp.4, 2017, https://doi.org/10.6114/jkood.2019.32.4.167
  3. 아토피피부염 및 건선 환자 증례를 통한 상한론 백호탕 조문의 '면구(面垢)'에 대한 새로운 해석 vol.34, pp.1, 2017, https://doi.org/10.15188/kjopp.2020.02.34.1.45
  4. 연령과 사상체질에 따른 개인건강기록(PHR)에 기반한 아토피피부염 환자의 특성 vol.35, pp.1, 2017, https://doi.org/10.7778/jpkm.2021.35.1.63