Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Effect of Sargassum serratifolium Extracts on β-Amyloid Production

β-아밀로이드 단백질 생성에 대한 톱니모자반(Sargassum serratifolium) 추출물의 효과

  • Choi, Min-Woo (Department of Food Science and Nutrition, Pukyong National University) ;
  • Jung, Cha-Gyun (Department of Neurophysiology and Brain Science, Nagoya City University Graduate School of Medical Sciences) ;
  • Kim, Hyeung-Rak (Department of Food Science and Nutrition, Pukyong National University) ;
  • Kim, Jae-Il (Department of Food Science and Nutrition, Pukyong National University)
  • 최민우 (부경대학교 식품영양학과) ;
  • 정차균 (나고야시립대학 대학원의학연구과 뇌신경생리학부) ;
  • 김형락 (부경대학교 식품영양학과) ;
  • 김재일 (부경대학교 식품영양학과)
  • Received : 2017.02.16
  • Accepted : 2017.02.21
  • Published : 2017.02.28
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Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of insidious onset that causes gradual loss of memory and cognitive function, and it is the most common form of dementia in the elderly. AD is characterized by neuritic plaques and neurofibrillary tangles in the brain, together with loss of neuronal cells. The major neuropathological hallmark of AD is the accumulation of extracellular neurotoxic ${\beta}-amyloid$ ($A{\beta}$) peptides, such as $A{\beta}1-42$, in the brain. In the present study, we investigated the effect of sargachromenol (SCM), sargaquinoic acid (SQA) and sargahydroquinoic acid (SHQA) isolated from Sargassum serratifoilum ethanol extract (SSE) on $A{\beta}$ production in vitro using APP751-transfected Chinese hamster ovary cells (CHO-751). CHO-751 cells were treated with various concentrations of SSE, SCM, SQA and SHQA, and the level of extracellular $A{\beta}1-42$ was evaluated by enzyme-linked immunosorbent assay. SSE and SHQA reduced the production of $A{\beta}1-42$ in CHO-751 cells. Therefore, SHQA isolated from S. serratifolium has potential as an inhibitor of neurotoxic $A{\beta}$ peptide production.

Keywords

References

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