The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Effects of Yijung-tang (YJT) on Experimental Hypothyroidism in Mice

이중탕(理中湯)이 생쥐에 유발된 갑상선기능저하증에 미치는 영향

  • Song, Yu-Rim (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Dong-Shin University) ;
  • Park, Kyung-Mi (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Dong-Shin University) ;
  • Yang, Seung-Jeong (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Dong-Shin University) ;
  • Lee, Eun-Kyu (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Dong-Shin University) ;
  • Lee, Seung-Ho (Baek-Jae Korean Medicine Clinic) ;
  • Cho, Seong-Hee (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Dong-Shin University)
  • 송유림 (동신대학교 한의과대학 부인과교실) ;
  • 박경미 (동신대학교 한의과대학 부인과교실) ;
  • 양승정 (동신대학교 한의과대학 부인과교실) ;
  • 이은규 (동신대학교 한의과대학 부인과교실) ;
  • 이승호 (백제한의원) ;
  • 조성희 (동신대학교 한의과대학 부인과교실)
  • Received : 2017.01.20
  • Accepted : 2017.02.14
  • Published : 2017.02.24
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Abstract

Objectives: The present study was carried out to investigate the effects of YJT on experimental hypothyroidism induced by sodium perchlorate and methimazolein in mice. Methods: 30 one-month-old C57BL6 mice were decided into 4 groups: 1) normal (n=6), 2) sodium perchlorate and methimazolein-induced hypothyroidism control (n=8), 3) hypothyroidism mice treated with low YJT (n=8), 4) hypothyroidism mice treated with high YJT (n=8). Sodium perchlorate and methimazolein were administered for 4 weeks, YJT (low and high) was administered for 2 weeks after sodium perchlorate and methimazolein were initiated for a total duration of 2 week. The changes were observed : weight of body, T3, T4, TSH, follicular cells in the thyroid tissues, LDL cholesterol, HDL cholesterol, triglyceride and free fatty acid, FBG, AST, ALT and so on. Results: YJT did not affect body weight gain. YJT restored free T4 level decreased by sodium perchlorate and methimazolein and prevented shrinking of follicles and proliferation of follicular cells in the thyroid tissues. In addition, YJT lowered total and LDL cholesterol levels elevated by sodium perchlorate and methimazolein respectively and ameliorated distribution of fat in liver tissues. In addition, the effect on fasting blood glucose (FBG), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were also investigated. Conclusions: These data suggest that YJT can be used to treat woman patients which are accompanied with hypothyroidism relatively safely.

Keywords

References

  1. Jo BY. Clinical Thyroidology. Seoul: Korea Medical Book Publishing Company. 2001:231-55, 409-41.
  2. National Health Insurance Service. Hypothyroidism[cited December 28, 2015]. Available from:URL:http://www.nhis.or.kr/bbs7/boards/B0039/15992.
  3. Gu BS. Clinical Gynecologic endocology. Seoul:Korea Medical Book Publishing Company. 2001:188.
  4. Burrow GN. The Thyroid gland and reproduction. In: Yen SSC. Jaffe RB, des. Reproductive endocrinology. Philadelphia: WB Saunders. 1986:4524-40.
  5. Monitor M, et al. Successful outcome of pregnancy in women with hypothyroidism. Ann Intern Med. 1981;94(1):31. https://doi.org/10.7326/0003-4819-94-1-31
  6. Lindsay AN, et al. Muticystic ovaties detecteer by sonography in children with hypothyroidism. Am J Dis Child. 1980;134:588.
  7. Wiersinga WM. Thyroid hormone replacement therapy. Horm Res. 2001;56:74-81.
  8. Do HK. Nephro-Endocrine system of Korean Medicine. Seoul:Korean Medicine Laboratory. 1993:729, 867-74, 1042, 1059-65.
  9. The Society of Korean Obstetrics and Gynecology. Korean Obstetrics and Gynecology(2). Seoul:Euiseongdang. 2012:193-8.
  10. Ko MG, Jang MK. Hyundae-Sanghanron. Seoul:Haneuimunhwasa. 2000:647-9.
  11. Hur J. Donguibogam. Seoul:Namsandang. 2007:382.
  12. College of Oriental Medicine, Professors of Prescriptionology. Prescriptionology. Seoul:Yeongrimsa. 2003:232-3.
  13. Seo CH, et al. Quantification Analysis and Antioxidant Activity of Leejung-tang. Official Journal of The Korean Medicine Society For The Herbal Formula Study. 2013;21(1):177-85.
  14. Shin IS, et al. Gastroprotective effects of Leejung-tang, an oriental traditional herbal formula, on ethanol-induced acute gastric injury in rats. Far J Trait Complement Altern Med. 2013;10:316-23.
  15. Seo HY, et al. The effect of Li Zhong tang on the suppression of The differentiation by IFN-${\gamma}$ response in IgE Hyperproduction and atopic dermatitis-like shin lesions induced NC/Nga mouse. J Korean Oriental Pediatrics. 2009;23:1-22.
  16. Seo HY, et al. Therapeutic Effects of Yijung-tang on atopic dermatitis-like skin lesions of NC/Nga mouse induced by mite antigen. J Korean Oriental Pediatrics. 2011;25:1-27.
  17. Koh KS, et al. Studies on the effects of aqua-acupuncture with Yi-Jung-tang extracts on the analgesia, anti-laxative and uropepsin value. J Korean Oriental Med. 1984;5:62-71.
  18. Lee JA, et al. Comparative study of 25 herbal formulas on anti-inflammatory effect. J Oriental Obstetrics & Gynecol. 2010;23:101-11.
  19. Kim SI, et al. The Effect of Anjeonlejoong -tang on Hypothyroidism : The Prospective Controlled Clinical Study. Korean J. Orient. Int. Med. 2004;fal:103-10.
  20. Hwang DC. Bang-Yak-Hap-Pyun. Seoul: Younglimsa. 2010:124-5.
  21. Tsourdi E, et al. Hyperthyroidism and Hypothyroidism in Male Mice and Their Effects on Bone Mass, Bone Turnover, and the Wnt Inhibitors Sclerostin and Dickkopf-1. Endocrinology. 2015;156(10):3517-27. https://doi.org/10.1210/en.2015-1073
  22. Cha BS. Internal Medicine understood by Pathophysiology Vol.9. Seoul:Jungdam. 2008:69-82.
  23. Guyton AC. Textbook of medical physiology. Phliadelphia:WB Saunder's Company. 1986:906-8.
  24. Choi JY, et al. Effects of Sipjeondaebotang on the white rat Hypothyroidism Induced by PTU(6-n-propyl-2-thiouracil). Official Journal of The Korean Medicine Society For The Herbal Formula Study. 2016;24(3):131-52.
  25. Park EY, KimDC. Effects of Insamyangyoung-tang Aqueous Extracts on the Hypothyroidism Induced by Propylthiouracil in Rats. J Korean Obstet Gynecol. 2015;28(2):55-75. https://doi.org/10.15204/jkobgy.2015.28.2.055
  26. Son JH, Kim DC. Effects of Yikgeebohyul -tang Aqueous Extracts on the Rat Hypothyroidism Induced by Propylthiouracil. J Korean Obstet Gynecol. 2015;28(3):54-73. https://doi.org/10.15204/jkobgy.2015.28.3.054
  27. Choi IG, et al. Effects of Jinmutang (JMT) on Hypothyroidism in Rats. Korean J. Orient. Int. Med. 2006;27(4):879-87.
  28. Lim BS, Kim CJ. The Effects of Woogwi-eum(Yougui-yin) on the Hypothyroidism of Rats. J Korean Oriental Med. 2000;44(4):26-36.
  29. Kim SJ, Kim DC. Effects of Jaeumkanghwa-tang on the Rat Hypothyroidism Induced by Propylthiouracil(PTU). J Korean Obstet Gynecol. 2014;27(1):41-64. https://doi.org/10.15204/JKOBGY2014.27.1.041
  30. Kim DH, et al. The Effects of Daeyoungjeon (DYJ) on the Hypothyroidism in Rats. Kor. J. Herbol. 2007;22(4):35-43.
  31. Joo JH, et al. Effects of Hyangsayangyi -tang Aqueous Extracts on the Hypothyroidism Related Hepatic Damages induced by PTU in Rats. J Physiol & Pathol Korean Med. 2015;29(5):394-402. https://doi.org/10.15188/kjopp.2015.10.29.5.394
  32. Cho CS, et al. The Effects of Danggwisaeyeoktang (當歸四逆湯) on the Hypothyroidism of Rats. Kor. J. Herbol. 2007;22(1):95-102.
  33. The compilation committee of Herbalogy, University College of Korean Medicine. Herbalogy textbook of The national University College of Korean Medicine. Seoul:Yeongrimsa. 2005:376, 573, 78, 84.
  34. Becker C. Prophylaxis and treatment of side effects due to iodinated contrast media relevant to radiological practice. Radiologe. 2007;47(9):768-73. https://doi.org/10.1007/s00117-007-1550-4
  35. Nakamura H, et al. Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' disease. J Clin Endocrinol Metab. 2007;92(6):2157-62. https://doi.org/10.1210/jc.2006-2135
  36. Mansourian AR. Metabolic pathways of tetraidothyronine and triidothyronine production by thyroid gland: a review of articles. Pak J Biol Sci. 2011;14(1):1-12. https://doi.org/10.3923/pjbs.2011.1.12
  37. Kim YS, et al. The Effects of Morinda Officinalis Radix on Thyroid function in Hypothyroidism Rat Model induced by 6-propyl, 2-thiouracil (PTU). Korean J. Orient. Int. Med. 2011;32(3):425-34.
  38. Isselbacher KJ, et al. Harrison's Internal Medicine 13th edition. Seoul:Jungdam. 1997:2099-101.
  39. Iwen KA, et al. Thyroid hormones and the metabolic syndrome. Eur Thyroid J. 2013;2(2):83-92. https://doi.org/10.1159/000351249
  40. Joffe BI, Distiller LA. Diabetes mellitus and hypothyroidism: Strange bedfellows or mutual companions. World J Diabetes. 2014;5(6):901-4. https://doi.org/10.4239/wjd.v5.i6.901
  41. Abd El-Kader SM, El-Den Ashmawy EM. Non-alcoholic fatty liver disease: The diagnosis and management. World J Hepatol. 2015;7(6):846-58. https://doi.org/10.4254/wjh.v7.i6.846

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