Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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Effects of Bia-hwan (Féiér-wán) on the Ovariectomized Rat Model of Osteoporosis

비아환(肥兒丸)이 난소적출로 유발된 흰쥐의 골다공증 모델에 미치는 영향

  • Cho, Chang-Young (Department of Anatomy, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Eun-Young (Department of Anatomy, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Dong Hee (Department of Anatomy, College of Korean Medicine, Kyung Hee University) ;
  • Kim, MinBeom (Department of Anatomy, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Sang-bae (Department of Anatomy, College of Korean Medicine, Kyung Hee University) ;
  • Yang, KyuJin (Department of Anatomy, College of Korean Medicine, Kyung Hee University) ;
  • Sohn, Youngjoo (Department of Anatomy, College of Korean Medicine, Kyung Hee University) ;
  • Jung, Hyuk-Sang (Department of Anatomy, College of Korean Medicine, Kyung Hee University)
  • 조창영 (경희대학교 한의과대학 해부학교실) ;
  • 김은영 (경희대학교 한의과대학 해부학교실) ;
  • 김동희 (경희대학교 한의과대학 해부학교실) ;
  • 김민범 (경희대학교 한의과대학 해부학교실) ;
  • 김상배 (경희대학교 한의과대학 해부학교실) ;
  • 양규진 (경희대학교 한의과대학 해부학교실) ;
  • 손영주 (경희대학교 한의과대학 해부학교실) ;
  • 정혁상 (경희대학교 한의과대학 해부학교실)
  • Received : 2017.03.23
  • Accepted : 2017.04.10
  • Published : 2017.04.30
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Abstract

Objectives Osteoporosis is a common disease in adults with prevalence rate of more than 40%, and occurs more to female than to male. The purpose of this study is to identify the effect of Bia-hwan ($F{\acute{e}}i{\acute{e}}r$-$w{\acute{a}}n$) on the osteoporosis of ovariectomized rats. Methods 24 female rats were randomly assigned to a SHAM group, a control group, and a BAH group. Ovaries of the control group and the BAH group were extracted. After than, general animal feed were given to the SHAM group and the control group, animal feed contained BAH were given to the BAH group through mouths of them. After 8 weeks, rats were sacrificed and their weight, calcium, phosphorus, estradiol, total-cholesterol, triglyceride, ALP, albumin, AST, ALT, the weight of femur and tibia ash per body ratio, both area and thickness of trabecular bone, the area of osteoblast and the number of osteoclast were measured. Results The level of calcium, phosphorus, AST in the serum of the BAH group increased significantly compared to the control group. There was no significant difference between the control group and the BAH group in the level of estradiol, total-cholesterol, triglyceride, ALP, albumin, and ALT in the serum. There was no significant difference between the control group and the BAH group in the weight of femur and tibia ash per body ratio. The thickness of trabecular of the BAH group increased significantly compared to the control group, but there was no significant difference in the trabecular area. The area of osteoblast and the number of osteoclast of the BAH group decreased significantly compared to the control group. Conclusions From the results of the above study, oral intake of BAH can inhibit the decrease of calcium, phosphorus in blood and prevent the thinning process of the trabecular by suppressing activation of osteoclast. Thus, BAH may have effects on the treatment and prevention of osteoporosis.

Keywords

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