DOI QR코드

DOI QR Code

A Monte Carlo Study of Dose Enhancement with kilovoltage and megavoltage photons

몬테칼로 기법을 이용한 kV, MV X선에서의 선량증가 효과 비교 평가

  • Hwang, ChulHwan (Departments of Radiation Oncology, Pusan National University Hospital) ;
  • Im, In-Chul (Department of Radiological Science, Dongeui University) ;
  • Kim, Jung-Hoon (Departments of Radiological Science, College of Health Sciences, Catholic University of Pusan)
  • 황철환 (부산대학교병원 방사선종양학과) ;
  • 임인철 (동의대학교 의료보건생활대학 방사선학과) ;
  • 김정훈 (부산가톨릭대학교 보건과학대학 방사선학과)
  • Received : 2017.02.15
  • Accepted : 2017.04.30
  • Published : 2017.04.30

Abstract

Monte Carlo simulations were used to assess dose enhancement effects for 60-, 90-, 120-, and 150-kV X-rays, and for 6- and 15-MV X-rays. The MCNPX code was used for a computer simulation of the ICRU slab phantom, and gold, gadolinium, and iron oxide (Fe2O3) were employed as dose enhancement agents. In consideration of the buildup region of the incident energy, agent concentrations of 5, 10, 15, and 20 mg/g were inserted on the surface of the phantom at a depth of 5 cm. Based on baseline values obtained in the absence of dose enhancement agents, a quantitative analysis was performed by evaluating depth-dependent changes in the absorbed energy and the dose enhancement factor (DEF). A higher concentration of dose enhancement agents led to a greater dose enhancement effect with iron oxide, gadolinium, and gold in descending order. For kilovoltage (kV) X-rays, as the incident energy was decreased and as the energy became closer to the ionization potential of the atoms in the enhancement agent, the dose enhancement effect increased. In the megavoltage (MV) X-ray range, dose enhancement was higher at 6 MV compared with 15 MV. However, the overall dose enhancements were significantly lower compared to the results obtained with kV X-rays.

Monte Carlo 기법을 활용하여 60, 90, 120, 150 kV와 6, 15 MV X선에서의 선량증가 효과를 평가하였다. MCNPX code를 이용하여 ICRU slab 모의피폭체를 전산모사하였으며, 금, 가돌리늄, 산화철의 선량증가 물질을 사용하였다. 입사에너지의 전자평형 지점을 고려하여 모의피폭체의 표면 및 5 cm 깊이에 5, 10, 15, 20 mg/g 농도의 물질을 삽입하였으며, 선량증가 물질이 없을 때를 바탕으로 하여 깊이에 따른 흡수에너지 변화와 선량증가효과비를 통하여 정량적 평가를 시행하였다. 선량증가 물질의 농도가 높을수록, 금, 가돌리늄, 산화철 순으로 높은 선량증가 효과를 보였으며, kV X선에서는 입사에너지가 낮을수록, 물질의 원자 내 전리 퍼텐셜에 가까울수록 높은 선량증가 효과를 보였다. MV X선에서는 15 MV에 비해 6 MV에서 높은 선량증가 현상을 나타내었으며, kV X선에 비해서는 현저히 낮은 결과를 확인할 수 있었다.

Keywords

References

  1. T. John and Lyman, "Complication probability as assessment from dose-volume histograms", Radiation Research, Vol. 104, pp.13-19, 1985. https://doi.org/10.2307/3576626
  2. P. Stavrev, N. Stavreva and A. Niemierko, "Generalization of a model of tissue response to radiation based on the ideas of functional subunits and binomia statistics", Physics in Medicine and Biology, Vol. 46, pp.1501-1518, 2001. https://doi.org/10.1088/0031-9155/46/5/312
  3. Pollack A, Zagars GK, Strarkshall G, Antolak JA, Lee JJ, et al, "Prostate cancer radiation dose-reponse: results of the M.D. Anderson Phase III randomized tiral". International Journal of Radiation Oncology Biology Physics, Vol. 53, pp. 1097-1105, 2002. https://doi.org/10.1016/S0360-3016(02)02829-8
  4. Sardi JE, Boixadera MA, Sardi JJ, et al.: "A critical overview of concurrent chemoradiotherapy in cervical cancer", Current Oncology Reports, Vol. 6, pp. 463-70, 2004. https://doi.org/10.1007/s11912-004-0077-3
  5. Kok HP, Crezee J, Franken NA, et al.: "Quantifying the combined effect of radiation therapy and hyperthermia in terms of equivalent dose distributions", International Journal of Radiation Oncology Biology Physics, Vol. 88, pp. 739-45, 2014. https://doi.org/10.1016/j.ijrobp.2013.11.212
  6. Cho SH, Jones BL, Krishnan S. "The dosimetric feasibility of gold nanoparticle-aided radiation therapy (GNRT) via brachytherapy using low-energy gamma x-ray sources". Physics in Medicine and Biology. Vol 54, pp. 4889-905, 2009 https://doi.org/10.1088/0031-9155/54/16/004
  7. Perez-Lopez CE, Garnica-Garza HM. "Monte Carlo modeling and optimization of contrast-enhanced radio therapy of brain tumors". Physics in Medicine and Biology. Vol 56, pp. 4059-72, 2011 https://doi.org/10.1088/0031-9155/56/13/020
  8. McMahon SJ, Hyland WB, Muir MF, Coulter JA, Jain S, Butterworth KT, et al. "Nanodosimetric effects of gold nanoparticles in megavoltage radiationtherapy". Radiotherapy and Oncology. Vol 100, pp. 412-6, 2011 https://doi.org/10.1016/j.radonc.2011.08.026
  9. Micheal KK, James CL, Devika BC et al, "Irradiation of gold nanoparticles by x-rays: Monte Carlo simulation of dose enhancements and the spatial properties of the secondary electron production", Medical. Physics. Vol. 38, pp. 624-631, 2011. https://doi.org/10.1118/1.3539623
  10. ChulHwan Hwang, Se-Sik Kang, Jung-Hoon Kim, "A Monte Carlo Study of Secondary Electron Production from Gold Nanoparticle in Kilovoltage and Megavolt age Energies". Journal of the Korean Society of Radiology, Vol 10, No 3, pp 153-159, 2015 https://doi.org/10.7742/jksr.2016.10.3.153
  11. Bahreyni Toossi MT, Ghorbani M, Mehrpouyan M et al. "A Monte Carlo study on tissue dose enhancement in brachytherapy: a comparison between gadolinium and gold nanoparticles". Australasian Physical and Engineering Science in Medicine Vol 35, pp 177-85, 2012 https://doi.org/10.1007/s13246-012-0143-3
  12. Khoei S1, Mahdavi SR, Fakhimikabir H, Shakeri-Zadeh A, Hashemian A., "The role of iron oxide nanoparticles in the radiosensitization of human prostate carcinoma cell line DU145 at megavoltage radiation energies". International Journal of Radiation Oncology Biology Physics. Vol 90, pp. 351-6, 2014 https://doi.org/10.3109/09553002.2014.888104
  13. Daniel G, Vladmir F. Eduardo G. Kujtim L, Geoffrey G, "Monte Carlo study of Radiation Dose Enhancement by Gadolinium in Megavoltage and High Dose Rate Radiotherapy", PLOSONE, Vol. 9, pp. 1-7, 2014
  14. Bahreyni Toossi M, Ghorbani M, Mehrpouyan M, Akbari F, Sobhkhiz Sabet L, et al. A "Monte Carlo study on tissue dose enhancement in brachytherapy: a comparison between gadolinium and gold nanoparticles". Australasian Physical and Engineering Sciences in Medicine Vol. 35, pp. 177-185, 2012 https://doi.org/10.1007/s13246-012-0143-3
  15. Corot C, Warlin D, "Superparamagnetic iron oxide nanoparticles for MRI: contrast media pharmaceutical company R&D perspective". Wiley Interdiscip Rev Nanomed Nanobiotechnol. Vol. 5, pp. 411-22, 2013. https://doi.org/10.1002/wnan.1225
  16. ICRU. Stopping Powers for Electrons and Positrons. Bethesda, MD: International Commission on Radiation Units and Measurements; 1984. International Commission on Radiation Units and Measurements. ICRU Report 37.
  17. Cranley K, Gilmore BJ, Fogarty GWA, et al, IPEM Report 78, Catalogue of Diagnostic X-ray Spectra and Other Data. The Institute of Physics and Engineering in Medicine, 1997
  18. Cranley K, Gilmore BJ, Fogaty GWA, "Catalogue of Diagnostic X-ray Spectra and Other data, Diagnostic Radiology and Magnetic Resonance Special Interest". Group of the Institute of Physics and Engineering in Medicine. pp. 4-43, 1997.
  19. Asghar M, Michael F, Mahmoud A, et al, "Monte Carlo calculation of Varian 2300C/D Linac photon beam characteristics: a comparison between MCNP4C, GEANT3 and measurements", Applied Radiation and Isotopes, Vol. 62, pp. 467-77, 2005.
  20. Mesbahi A, Jamali F, Gharehaghaji, N et al, "Effect of photon beam energy, gold nanoparticle size and concentration on the dose enhancement in radiation therapy" BioImpacts, Vol. 3, pp. 29-35, 2013.
  21. N. Ramesh and S. Sharma, "Dose enhancement in gold nanoparticle-aided radiotherapy for the therapeutic photon beams using Monte Carlo technique", Journal of Cancer Research and Therapeutics, Vol. 11, pp.94-97, 2011.
  22. SoRa K, "Feasibility study on the use of gold nanoparticles as a dose enhancement agent for a superficial X-ray therapy applied to melanoma", Seoul national university gradudate school.
  23. Faiz M. Khan, The physics of radiation therapy, Fourth edition, Wolters Kluwer Lippincott Williams & Wilkins.
  24. Albert Thompson, David Attwood, Eric Gullikson etc, X-RAY DATA BOOKLET, Lawrence Berkeley National Laboratory, University of California Berkeley, 2009

Cited by

  1. Verification of Secondary Electron Generated by Head Screw in Gamma Knife Using Monte Carlo N-Particle Simulation vol.31, pp.2, 2017, https://doi.org/10.14316/pmp.2020.31.2.29