Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)

Korean Society of Radiological Science (대한방사선과학회)
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Radiation Protection Effect of Selenium on the Rat's Prostate

흰쥐의 전립선에 대한 셀레늄(Se)의 방사선 방호효과

  • Choi, Hyung-Seok (Department of Emergency Management, Inje University) ;
  • Choi, Jun-Hyeok (Radiation Safety Research Center, Inje University) ;
  • Jung, Do-Young (Department of Emergency Management, Inje University) ;
  • Kim, Jang-Oh (Department of Emergency Management, Inje University) ;
  • Shin, Ji-Hye (Department of Emergency Management, Inje University) ;
  • Kim, Joo-Hee (Department of Emergency Management, Inje University) ;
  • Min, Byung-In (Department of Nuclear Applied Engineering, Inje University)
  • 최형석 (인제대학교 재난관리학과) ;
  • 최준혁 (인제대학교 방사선방재센터) ;
  • 정도영 (인제대학교 재난관리학과) ;
  • 김장오 (인제대학교 재난관리학과) ;
  • 신지혜 (인제대학교 재난관리학과) ;
  • 김주희 (인제대학교 재난관리학과) ;
  • 민병인 (인제대학교 원자력응용공학부)
  • Received : 2017.05.18
  • Accepted : 2017.06.09
  • Published : 2017.06.30
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Abstract

High-tech medical equipment has increased the utilization of radiation in the medical field. As a result, research on radiation protection using natural materials has become an important social issue. Selenium is a natural substance that is highly expressed in prostate known that an essential role in prostate cells. Selenium was orally administered to Rat and irradiated with 10 Gy of radiation. Then, the prostate tissue w as used as a target organ for 1 day, 7 days and 21 days to investigate the radiation protection effect of selenium through changes of blood components, Superoxide Dismutase and histological changes. As a result, there was a significant protective effect of hematopoietic immune system(hemoglobin concentration, neutrophil, platelet) in the group irradiated with selenium(p<0.05). the observation of tissue changes selenium is an effective component to increase Superoxide Dismutase activity, and it was confirmed that it has an effect of inhibiting the expression of hypertrophy of prostate by irradiation. Therefore, it is considered that selenium can be utilized as a radioprotective agent by inducing prevention of prostate-related diseases.

첨단 의료 장비의 보급으로 의료 분야의 방사선 활용도가 증가하면서 천연물을 활용한 방사선 방호제 연구는 사회적으로 중요한 과제가 되고 있다. 천연물인 셀레늄(Se)이 전립선에서 높게 발현되며 전립선 세포에 필수적인 역할을 한다는 것으로 알려져 있다. 전립선 조직을 대상으로 셀레늄에 의한 방사선 방호 효과를 연구하기 위하여 10 Gy의 방사선을 조사 시킨 후 1, 7, 21일 기간에 따른 혈구성분 및 항산화효소(Superoxide Dismutase; SOD) 활성 변화와 조직학적 변화를 관찰하였다. 방사선조사군(Rad)에 비해 셀레늄 투여 후 방사선조사군(Se+Rad)에서 조혈면역계의 손상을 경감시키는 유의한 방호 효과가 있었다(p<0.05). 셀레늄이 항산화효소인 Superoxide Dismutase(SOD)의 활성을 증가시키는 유효한 성분이며, 방사선 조사에 의한 전립선비대증의 발현을 억제하는 효과가 있음을 확인하였다. 셀레늄이 부득이하게 수반되는 방사선 피폭으로 인한 전립선 관련 질병의 예방과 방사선 방호제로서 유용성이 있을 것이라 사료된다.

Keywords

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