Investigative and Clinical Urology

The Korean Urological Association (대한비뇨의학회)
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Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility

  • Agarwal, Ashok (American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic) ;
  • Bui, Albert Danh (American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic)
  • Received : 2017.09.04
  • Accepted : 2017.10.15
  • Published : 2017.11.22
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Abstract

Male infertility affects men worldwide. Oxidative stress (OS), characterized by an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, is one of the major causes of male infertility. OS causes damage at the molecular level, which impairs lipids, proteins, and DNA. The cyclic cascade of redox reactions weakens sperm function which leads to poor semen parameters and eventual sterility. There is a need for advanced diagnostic tests that can quickly and accurately detect OS. Most commonly used assays can only measure single constituents of OS. However, the MiOXSYS System introduces a new strategy to detect OS by measuring the oxidation-reduction potential (ORP)--a direct evaluation of the redox balance between ROS and antioxidants. The MiOXSYS System has shown promise as a diagnostic tool in the evaluation of male infertility. This review explores the concept of ORP, details the principle of the MiOXSYS System, and summarizes the findings in clinical studies that support ORP measurement in semen.

Keywords

References

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  9. MOTILIPERM Ameliorates Immobilization Stress-Induced Testicular Dysfunction via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway in SD Rats vol.21, pp.13, 2020, https://doi.org/10.3390/ijms21134750
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  11. Relationship of Seminal Oxidation-Reduction Potential with Sperm DNA Integrity and pH in Idiopathic Infertile Patients vol.9, pp.9, 2020, https://doi.org/10.3390/biology9090262
  12. Oxidative Stress is Associated with Reduced Sperm Motility in Normal Semen vol.14, pp.5, 2017, https://doi.org/10.1177/1557988320939731
  13. Oxidative and nitrosative stress in frozen-thawed pig spermatozoa. II: Effect of the addition of saccharides to freezing medium on sperm function vol.97, pp.None, 2020, https://doi.org/10.1016/j.cryobiol.2020.10.015
  14. Voltammetric Behaviour of Drug Molecules as a Predictor of Metabolic Liabilities vol.88, pp.4, 2020, https://doi.org/10.3390/scipharm88040046
  15. A Novel Endothelial Damage Inhibitor Reduces Oxidative Stress and Improves Cellular Integrity in Radial Artery Grafts for Coronary Artery Bypass vol.8, pp.None, 2021, https://doi.org/10.3389/fcvm.2021.736503
  16. Diagnostic value of advanced semen analysis in evaluation of male infertility vol.53, pp.2, 2017, https://doi.org/10.1111/and.13625
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  18. Comparative study of fertility parameters in vitrified human spermatozoa in the presence or absence of EmbryORP ® : A novel antioxidant vol.53, pp.4, 2017, https://doi.org/10.1111/and.13886
  19. The effect of paternal age on intracytoplasmic sperm injection outcome in unexplained infertility vol.19, pp.3, 2021, https://doi.org/10.1080/2090598x.2021.1955553
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