Journal of Korean Medical Science

Korean Acad Medical Sciences (대한의학회)
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Recovery Rates of Non-Tuberculous Mycobacteria from Clinical Specimens Are Increasing in Korean Tertiary-Care Hospitals

  • Kim, Namhee (Department of Laboratory Medicine, Pusan National University Hospital) ;
  • Yi, Jongyoun (Department of Laboratory Medicine, Pusan National University Hospital) ;
  • Chang, Chulhun L. (Department of Laboratory Medicine, Pusan National University Yangsan Hospital)
  • Received : 2017.01.13
  • Accepted : 2017.05.12
  • Published : 2017.08.10
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Abstract

Non-tuberculous mycobacteria (NTM) are being recognized increasingly as the causative agents of opportunistic infections in humans. This study investigated the epidemiologic trends of NTM recovery from various clinical specimens in 2 Korean tertiary-care hospitals. We reviewed the laboratory records of patient samples cultured for mycobacteria between 2009 and 2015 at 2 tertiary-care hospitals in Korea. The medical records for patients with positive NTM samples were also reviewed. During the study period, 144,540 specimens were cultured for mycobacteria. The proportion of NTM-positive samples increased from 23.3% in 2009 to 48.2% in 2015. The 2 most frequently isolated NTM were Mycobacterium intracellulare (38.3%) and M. avium (23.1%). The number of clinically significant diseases caused by NTM in inpatients and outpatients increased from 6.8 to 12.9 per 100,000 patients over the same period. The rates of recovery of NTM from clinical specimens and the number of patients with NTM infections increased significantly (P < 0.001, testing for trend) between 2009 and 2015.

Keywords

Acknowledgement

Supported by : Pusan National University Yangsan Hospital

References

  1. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, Holland SM, Horsburgh R, Huitt G, Iademarco MF, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007; 175: 367-416. https://doi.org/10.1164/rccm.200604-571ST
  2. Saleeb P, Olivier KN. Pulmonary nontuberculous mycobacterial disease: new insights into risk factors for susceptibility, epidemiology, and approaches to management in immunocompetent and immunocompromised patients. Curr Infect Dis Rep 2010; 12: 198-203. https://doi.org/10.1007/s11908-010-0103-6
  3. Khan K, Wang J, Marras TK. Nontuberculous mycobacterial sensitization in the United States: national trends over three decades. Am J Respir Crit Care Med 2007; 176: 306-13. https://doi.org/10.1164/rccm.200702-201OC
  4. Billinger ME, Olivier KN, Viboud C, de Oca RM, Steiner C, Holland SM, Prevots DR. Nontuberculous mycobacteria-associated lung disease in hospitalized persons, United States, 1998-2005. Emerg Infect Dis 2009; 15: 1562-9. https://doi.org/10.3201/eid1510.090196
  5. Thomson RM; NTM working group at Queensland TB Control Centre and Queensland Mycobacterial Reference Laboratory. Changing epidemiology of pulmonary nontuberculous mycobacteria infections. Emerg Infect Dis 2010; 16: 1576-83. https://doi.org/10.3201/eid1610.091201
  6. Cook JL. Nontuberculous mycobacteria: opportunistic environmental pathogens for predisposed hosts. Br Med Bull 2010; 96: 45-59. https://doi.org/10.1093/bmb/ldq035
  7. Ryoo SW, Shin S, Shim MS, Park YS, Lew WJ, Park SN, Park YK, Kang S. Spread of nontuberculous mycobacteria from 1993 to 2006 in Koreans. J Clin Lab Anal 2008; 22: 415-20. https://doi.org/10.1002/jcla.20278
  8. Chae DR, Kim YI, Kee SJ, Kim YH, Chi SY, Ban HJ, Kwon YS, Oh IJ, Kim KS, Kim SO, et al. The impact of the 2007 ATS/IDSA diagnostic criteria for nontuberculous mycobacterial disease on the diagnosis of nontuberculous mycobacterial lung disease. Respiration 2011; 82: 124-9. https://doi.org/10.1159/000320254
  9. Pfyffer GE. Mycobacterium: general characteristics, laboratory detection, and staining procedures. In: Jorgensen JH, Pfaller MA, Carroll KC, Funke G, Landry ML, Richter SS, Warnock DW, editors. Manual of Clinical Microbiology. 11th ed. Washington, D.C., ASM Press, 2015, p536-69.
  10. Lee SK, Lee EJ, Kim SK, Chang J, Jeong SH, Kang YA. Changing epidemiology of nontuberculous mycobacterial lung disease in South Korea. Scand J Infect Dis 2012; 44: 733-8. https://doi.org/10.3109/00365548.2012.681695
  11. Koh WJ, Chang B, Jeong BH, Jeon K, Kim SY, Lee NY, Ki CS, Kwon OJ. Increasing recovery of nontuberculous mycobacteria from respiratory specimens over a 10-year period in a tertiary referral hospital in South Korea. Tuberc Respir Dis 2013; 75: 199-204. https://doi.org/10.4046/trd.2013.75.5.199
  12. Park YS, Lee CH, Lee SM, Yang SC, Yoo CG, Kim YW, Han SK, Shim YS, Yim JJ. Rapid increase of non-tuberculous mycobacterial lung diseases at a tertiary referral hospital in South Korea. Int J Tuberc Lung Dis 2010; 14: 1069-71.
  13. Sakatani M. The non-tuberculous mycobacteriosis. Kekkaku 2005; 80: 25-30.
  14. Management of opportunist mycobacterial infections: Joint Tuberculosis Committee Guidelines 1999. Subcommittee of the Joint Tuberculosis Committee of the British Thoracic Society. Thorax 2000; 55: 210-8. https://doi.org/10.1136/thorax.55.3.210
  15. Ding LW, Lai CC, Lee LN, Hsueh PR. Disease caused by non-tuberculous mycobacteria in a university hospital in Taiwan, 1997-2003. Epidemiol Infect 2006; 134: 1060-7. https://doi.org/10.1017/S0950268805005698
  16. Simner PJ, Stenger S, Richter E, Brown-Elliott BA, Wallace RJ, Wengenack NL. Mycobacterium: laboratory characteristics of slowly growing mycobacteria. In: Jorgensen JH, Pfaller MA, Carroll KC, Funke G, Landry ML, Richter SS, Warnock DW, editors. Manual of Clinical Microbiology. 11th ed. Washington, D.C., ASM Press, 2015, p570-94.
  17. Falkinham JO 3rd. Ecology of nontuberculous mycobacteria--where do human infections come from? Semin Respir Crit Care Med 2013; 34: 95-102. https://doi.org/10.1055/s-0033-1333568
  18. Hong KS, Ahn JH, Choi EY, Jin HJ, Shin KC, Chung JH, Lee KH. Microbiologic distribution and clinical features of nontuberculous mycobacteria in the tertiary hospital in Daegu. Yeungnam Univ J Med 2015; 32: 71-9. https://doi.org/10.12701/yujm.2015.32.2.71
  19. Glassroth J. Pulmonary disease due to nontuberculous mycobacteria. Chest 2008; 133: 243-51. https://doi.org/10.1378/chest.07-0358
  20. Kim CK, Sung H, Park YJ, Chang CL. A proposal for laboratory workflow changes for efficient tuberculosis control. Ann Clin Microbiol 2013; 16: 61-8. https://doi.org/10.5145/ACM.2013.16.2.61

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