Experimental and Molecular Medicine

Korean Society for Biochemistry and Molecular Biongy (생화학분자생물학회)
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Microbiota in T-cell homeostasis and inflammatory diseases

  • Lee, Naeun (Center for Integrative Rheumatoid Transcriptomics and Dynamics, College of Medicine, The Catholic University of Korea) ;
  • Kim, Wan-Uk (Center for Integrative Rheumatoid Transcriptomics and Dynamics, College of Medicine, The Catholic University of Korea)
  • Received : 2016.12.12
  • Accepted : 2017.01.02
  • Published : 2017.05.31
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Abstract

The etiology of disease pathogenesis can be largely explained by genetic variations and several types of environmental factors. In genetically disease-susceptible individuals, subsequent environmental triggers may induce disease development. The human body is colonized by complex commensal microbes that have co-evolved with the host immune system. With the adaptation to modern lifestyles, its composition has changed depending on host genetics, changes in diet, overuse of antibiotics against infection and elimination of natural enemies through the strengthening of sanitation. In particular, commensal microbiota is necessary in the development, induction and function of T cells to maintain host immune homeostasis. Alterations in the compositional diversity and abundance levels of microbiota, known as dysbiosis, can trigger several types of autoimmune and inflammatory diseases through the imbalance of T-cell subpopulations, such as Th1, Th2, Th17 and Treg cells. Recently, emerging evidence has identified that dysbiosis is involved in the progression of rheumatoid arthritis, type 1 and 2 diabetic mellitus, and asthma, together with dysregulated T-cell subpopulations. In this review, we will focus on understanding the complicated microbiota-T-cell axis between homeostatic and pathogenic conditions and elucidate important insights for the development of novel targets for disease therapy.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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  15. Gut microbiota in ALS: possible role in pathogenesis? vol.19, pp.9, 2019, https://doi.org/10.1080/14737175.2019.1623026
  16. Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis vol.12, pp.6, 2017, https://doi.org/10.1038/s41385-019-0201-1
  17. The gut microbiota modulator berberine ameliorates collagen‐induced arthritis in rats by facilitating the generation of butyrate and adjusting the intestinal hypoxia and nitrate supply vol.33, pp.11, 2017, https://doi.org/10.1096/fj.201900425rr
  18. Individuals at risk of seropositive rheumatoid arthritis: the evolving story vol.286, pp.6, 2019, https://doi.org/10.1111/joim.12980
  19. The Th17/Treg Cell Balance: A Gut Microbiota-Modulated Story vol.7, pp.12, 2019, https://doi.org/10.3390/microorganisms7120583
  20. Narirutin suppresses M1-related chemokine interferon-gamma-inducible protein-10 production in monocyte-derived M1 cells via epigenetic regulation vol.16, pp.71, 2017, https://doi.org/10.4103/pm.pm_105_20
  21. The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases vol.11, pp.None, 2017, https://doi.org/10.3389/fmicb.2020.00301
  22. Short-Term Amoxicillin-Induced Perturbation of the Gut Microbiota Promotes Acute Intestinal Immune Regulation in Brown Norway Rats vol.11, pp.None, 2017, https://doi.org/10.3389/fmicb.2020.00496
  23. T cell subsets and functions in atherosclerosis vol.17, pp.7, 2017, https://doi.org/10.1038/s41569-020-0352-5
  24. The Effect of Intestinal Microbiome on the Effectiveness of Antitumor Immunotherapy vol.14, pp.3, 2017, https://doi.org/10.1134/s1990750820030105
  25. Effects of Vigiis 101-LAB on a healthy population's gut microflora, peristalsis, immunity, and anti-oxidative capacity: A randomized, double-blind, placebo-controlled clinical study vol.6, pp.9, 2017, https://doi.org/10.1016/j.heliyon.2020.e04979
  26. Single‐Cell Immune Profiling in Coronary Artery Disease: The Role of State‐of‐the‐Art Immunophenotyping With Mass Cytometry in the Diagnosis of Atherosclerosis vol.9, pp.24, 2017, https://doi.org/10.1161/jaha.120.017759
  27. Bacterial infections in lupus: Roles in promoting immune activation and in pathogenesis of the disease vol.4, pp.None, 2017, https://doi.org/10.1016/j.jtauto.2020.100078
  28. The Gut Microbiota and Its Relevance to Peripheral Lymphocyte Subpopulations and Cytokines in Patients with Rheumatoid Arthritis vol.2021, pp.None, 2017, https://doi.org/10.1155/2021/6665563
  29. Role of Intestinal Microbiota on Gut Homeostasis and Rheumatoid Arthritis vol.2021, pp.None, 2017, https://doi.org/10.1155/2021/8167283
  30. Integrated Fecal Microbiome and Serum Metabolomics Analysis Reveals Abnormal Changes in Rats with Immunoglobulin A Nephropathy and the Intervention Effect of Zhen Wu Tang vol.11, pp.None, 2017, https://doi.org/10.3389/fphar.2020.606689
  31. Virus Infection Is an Instigator of Intestinal Dysbiosis Leading to Type 1 Diabetes vol.12, pp.None, 2021, https://doi.org/10.3389/fimmu.2021.751337
  32. Gut Microbiota as Regulators of Th17/Treg Balance in Patients With Myasthenia Gravis vol.12, pp.None, 2021, https://doi.org/10.3389/fimmu.2021.803101
  33. Alterations of Gut Microbiota in Patients With Graves’ Disease vol.11, pp.None, 2017, https://doi.org/10.3389/fcimb.2021.663131
  34. Coccidia-Microbiota Interactions and Their Effects on the Host vol.11, pp.None, 2017, https://doi.org/10.3389/fcimb.2021.751481
  35. The Role of Microbiome and Virome in Idiopathic Pulmonary Fibrosis vol.9, pp.4, 2017, https://doi.org/10.3390/biomedicines9040442
  36. The Role of Enterobacteriaceae in Gut Microbiota Dysbiosis in Inflammatory Bowel Diseases vol.9, pp.4, 2017, https://doi.org/10.3390/microorganisms9040697
  37. Targeting the gut-liver-immune axis to treat cirrhosis vol.70, pp.5, 2017, https://doi.org/10.1136/gutjnl-2020-320786
  38. Anti-Inflammatory and Immunomodulatory Properties of Fermented Plant Foods vol.13, pp.5, 2021, https://doi.org/10.3390/nu13051516
  39. Gut Microbiota, in the Halfway between Nutrition and Lung Function vol.13, pp.5, 2021, https://doi.org/10.3390/nu13051716
  40. Treatment and mechanism of fecal microbiota transplantation in mice with experimentally induced ulcerative colitis vol.246, pp.13, 2017, https://doi.org/10.1177/15353702211006044
  41. Gut microbiome-host interactions in driving environmental pollutant trichloroethene-mediated autoimmunity vol.424, pp.None, 2017, https://doi.org/10.1016/j.taap.2021.115597
  42. Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis vol.89, pp.None, 2017, https://doi.org/10.1016/j.nut.2021.111282
  43. The Influence of Diet and Probiotics on the Response of Solid Tumours to Immunotherapy: Present and Future Perspectives vol.11, pp.18, 2017, https://doi.org/10.3390/app11188445
  44. Overview of the microbiota in the gut-liver axis in viral B and C hepatitis vol.27, pp.43, 2017, https://doi.org/10.3748/wjg.v27.i43.7446
  45. Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice vol.11, pp.1, 2021, https://doi.org/10.1038/s41598-021-90888-y
  46. Efficacy of probiotics for managing infantile colic due to their anti-inflammatory properties: a meta-analysis and systematic review vol.64, pp.12, 2017, https://doi.org/10.3345/cep.2020.01676
  47. Risk Factors for Infections, Antibiotic Therapy, and Its Impact on Cancer Therapy Outcomes for Patients with Solid Tumors vol.11, pp.12, 2021, https://doi.org/10.3390/life11121387