Yonsei Medical Journal

Yonsei Univ College Medicine (연세대학교의과대학)
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Impact of Serum Leptin to Adiponectin Ratio on Regression of Metabolic Syndrome in High-Risk Individuals: The ARIRANG Study

  • Kang, Dae Ryong (Department of Humanities and Social Medicine, Ajou University School of Medicine) ;
  • Yadav, Dhananjay (Department of Preventive Medicine, Yonsei University Wonju College of Medicine) ;
  • Koh, Sang-Baek (Department of Preventive Medicine, Yonsei University Wonju College of Medicine) ;
  • Kim, Jang-Young (Institute of Genomic Cohort, Yonsei University) ;
  • Ahn, Song Vogue (Department of Preventive Medicine, Yonsei University Wonju College of Medicine)
  • Received : 2016.07.25
  • Accepted : 2016.09.29
  • Published : 2017.03.01
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Abstract

Purpose: The ratio of serum leptin to adiponectin (L/A ratio) could be used as a marker for insulin resistance. However, few prospective studies have investigated the impact of L/A ratio on improvement of metabolic components in high-risk individuals with metabolic syndrome. We examined the association between L/A ratio and the regression of metabolic syndrome in a population-based longitudinal study. Materials and Methods: A total of 1017 subjects (431 men and 586 women) with metabolic syndrome at baseline (2005-2008) were examined and followed (2008-2011). Baseline serum levels of leptin and adiponectin were analyzed by radioimmunoassay. Area under the receiver operating characteristics curve (AUROC) analyses were used to assess the predictive ability of L/A ratio for the regression of metabolic syndrome. Results: During an average of 2.8 years of follow-up, metabolic syndrome disappeared in 142 men (32.9%) and 196 women (33.4%). After multivariable adjustment, the odds ratios (95% confidence interval) for regression of metabolic syndrome in comparisons of the lowest to the highest tertiles of L/A ratio were 1.84 (1.02-3.31) in men and 2.32 (1.37-3.91) in women. In AUROC analyses, L/A ratio had a greater predictive power than serum adiponectin for the regression of metabolic syndrome in both men (p=0.024) and women (p=0.019). Conclusion: Low L/A ratio is a predictor for the regression of metabolic syndrome. The L/A ratio could be a useful clinical marker for management of high-risk individuals with metabolic syndrome.

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Acknowledgement

Supported by : Korea Centers for Disease Control and Prevention

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