The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Interactions between herbal medicines and synthetic antihypertensive drugs

단미 한약과 합성 혈압약의 상호작용

  • Oh, Yoona (Division of Pharmacology, School of Korean Medicine, Pusan National University) ;
  • Lee, Hongbum (Division of Pharmacology, School of Korean Medicine, Pusan National University) ;
  • Kim, Hyungwoo (Division of Pharmacology, School of Korean Medicine, Pusan National University)
  • 오유나 (부산대학교 한의학전문대학원 약물의학부) ;
  • 이홍범 (부산대학교 한의학전문대학원 약물의학부) ;
  • 김형우 (부산대학교 한의학전문대학원 약물의학부)
  • Received : 2018.09.27
  • Accepted : 2018.11.25
  • Published : 2018.11.30
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Abstract

Objective : Many patients take antihypertensive drugs as well as herbal medicines at the same time in order to treat other symptoms or to keep their well-being. In this study, interactions between herbal medicines and synthetic antihypertensive drugs were analyzed. Methods : To investigate the interaction between herbal medicines and synthetic antihypertensive drugs, three electronic databases, including OASIS, Mediline and Sciencedirect were searched. Experimental and clinical studies on the interaction between herbal medicines and antihypertensive drugs were independently reviewed and included. Results : Analyzing selected studies, twenty herbs were found to interact with antihypertensive drugs. Herbs found to increase the antihypertensive effect were Panax ginseng, Carthamus tinctorius, Magnolia officinalis, Silybum marianum, Scutellaria baicalensis, Schisandra chinensis, Sophora flavescens, Piper nigrum, Curcuma longa, Ginkgo biloba, Juncus effuses and Hydrastis canadensis. In contrast, Commiphora myrrha, Rhodiola rosea, Hypericum perforatum, Eurycoma longifolia, and Daturae metel were found to inhibit the antihypertensive effect. Stephania tetrandra could increase or decrease the effect depending on the type of antihypertensive drug. Epedria sínica was suspected of pharmacodynamic interaction with antihypertensive drug. Glycyrrhiza uralensis has been reported to have serious side effects in combination with antihypertensive drugs. Conclusion : These results imply that when used in combination with herbal medicines and synthetic antihypertensive drugs, proper doses and herbs which are to avoid need to be informed to the patients. Despite concerns about interactions between herbal medicines and synthetic drugs, related research is very limited. More systematic researches are needed to give information on patient safety as well as to guide clinical practice.

Keywords

DHBCBU_2018_v33n6_9_f0001.tif 이미지

Fig. 1 Flow diagram of study selection and identification

Table 1. Herbs-Antihypertensive drugs interactions

DHBCBU_2018_v33n6_9_t0001.tif 이미지

Table 2. List of hypertensive drugs interacted with herbs

DHBCBU_2018_v33n6_9_t0002.tif 이미지

Table 3. List of herbs which increase or decrease the bioavailability of antihypertensive drugs

DHBCBU_2018_v33n6_9_t0003.tif 이미지

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