The Journal of the Convergence on Culture Technology (문화기술의 융합)

The International Promotion Agency of Culture Technology (국제문화기술진흥원)
권호 표지
DOI QR코드

DOI QR Code

Improvement of Insulin Resistance by Curcumin in High Fat Diet Fed Mice

고지방식이 급여 마우스에서 curcumin의 인슐린 저항성 개선 효능

  • 김단비 (대구가톨릭대학교 식품영양학과) ;
  • 안은영 (대구가톨릭대학교 식품영양학과) ;
  • 김은정 (대구가톨릭대학교 식품영양학과)
  • Received : 2017.12.25
  • Accepted : 2018.02.06
  • Published : 2018.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

Rapid increase of diabetic population is a major health concern in Korea. In a trial to develop food components which can prevent and/or cure diabetes, we investigated the anti-diabetic activity of curcumin in high fat diet (HFD)-induced type 2 diabetes mellitus (T2DM) animal model. C57BL/6 mice were divided into three groups: normal diet (ND), high fat diet (HFD), and curcumin (CUR, HFD+0.02% curcumin). Mice were fed each diet for 16 weeks. CUR significantly reduced body weight gain, the levels of plasma glucose, insulin, total-cholesterol (T-C), and LDL-C, whereas increased HDL-C compared to those of HFD group. Notably, insulin signaling pathway was activated by CUR. This suggests that CUR improves obesity-associated T2DM by overcoming insulin resistance in part.

당뇨 환자의 급격한 증가는 한국의 주요 건강문제중 하나이다. 당뇨 예방 또는 치료용 식품개발에 대한 노력의 일환으로 본 연구에서는 고지방식이급여로 유도한 제2형 당뇨동물모델에서 커큐민의 항당뇨효능을 연구하였다. C57BL/6 마우스를 정상식이, 고지방식이, 그리고 고지방식이에 0.02% 커큐민을 급여한 군으로 나누고 각 식이를 총 16주간 급여하였다. 그 결과, 커큐민 급여군이 고지방식이급여군에 비해 체중 증가량, 혈당, 혈중 인슐린, 총콜레스테롤, LDL-콜레스테롤 농도가 유의적으로 감소하였고 반면에 HDL-콜레스테롤 수준은 증가하였다. 또한 커큐민의 급여는 인슐린 신호전달체계를 활성화시켰다. 이러한 결과는 커큐민이 인슐린 저항성을 일부 극복시킴으로써 비만과 연관된 제2형 당뇨병을 개선시킬 수 있음을 제시한다.

Keywords

References

  1. Korean Diabetes Association, "Diabetes Fact Sheet in Korea" 2016.
  2. J. A. Martyn, M. Kaneki and S. Yasuhara, "Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms," Anesthesiology, Vol. 109, No. 1, pp. 137-148, Jul 2008. https://doi.org/10.1097/ALN.0b013e3181799d45
  3. O. Osborn and J. M. Olefsky, "The cellular and signaling networks linking the immune system and metabolism in disease," Nature medicine, Vol. 18, No. 3, pp. 363-374, March 2012. https://doi.org/10.1038/nm.2627
  4. S. Tateya, F. Kim and Y. Tamori, "Recent advances in obesity-induced inflammation and insulin resistance," Frontiers in endocrinology, Vol. 4, No. 93, pp. 1-14, Aug 2013.
  5. L. Van Gaal and A. Scheen, "Weight management in type 2 diabetes: current and emerging approaches to treatment," Diabetes Care, Vol. 38, No. 6, pp. 1161-1172, Jun 2015. https://doi.org/10.2337/dc14-1630
  6. S. Prasad, S. C. Gupta, A. K. Tyagi and B. B. Aggarwal, "Curcumin, a component of golden spice: from bedside to bench and back," Biotechnology advances, Vol. 32, No. 6, pp. 1053-1064, Nov 2014. https://doi.org/10.1016/j.biotechadv.2014.04.004
  7. P. G. Bradford, "Curcumin and Obesity," Biofactors, Vol. 39, No. 1, pp. 78-87, Jan 2013. https://doi.org/10.1002/biof.1074
  8. B. B. Aggarwal, "Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals," Annual review of nutrition, Vol. 30, pp. 173-199, Aug 2010. https://doi.org/10.1146/annurev.nutr.012809.104755
  9. A. S. Jimenez-Osorio, A. Monroy and S. Alavez, "Curcumin and insulin resistance-Molecular targets and clinical evidences," Biofactors, Vol. 42, No. 6, pp. 561-580, Nov 2016. https://doi.org/10.1002/biof.1302
  10. Z. Ghorbani, A. Hekmatdoost and P. Mirmiran, "Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin," International journal of endocrinology and metabolism, Vol. 12, No. 4, pp. e18081, Oct 2014.
  11. A. Takaguri, K. Satoh, M. Itagaki, Y. Tokumitsu and K. Ichihara, "Effects of Atorvastatin and Pravastatin on Signal Transduction Related to Glucose Uptake in 3T3L1 Adipocytes," Journal of pharmacological sciences, Vol. 107, No. 1, pp. 80-89, May 2008. https://doi.org/10.1254/jphs.FP0072403
  12. R. C. Russell, C. Fang and K. L. Guan, "An emerging role for TOR signaling in mammalian tissue and stem cell physiology," Development, Vol. 138, No. 16, pp. 3343-3356, Aug 2011. https://doi.org/10.1242/dev.058230
  13. M. Laplante and D. M. Sabatini, "mTOR signaling in growth control and disease," Cell, Vol. 149, No. 2, pp. 274-293, Apr 2012. https://doi.org/10.1016/j.cell.2012.03.017
  14. L. Khamzina, A. Veilleux, S. Bergeron and A. Marette, "Increased Activation of the Mammalian Target of Rapamycin Pathway in Liver and Skeletal Muscle of Obese Rats: Possible Involvement in Obesity-Linked Insulin Resistance," Endocrinology, Vol. 146, No. 3, pp. 1473-1481, Dec 2005. https://doi.org/10.1210/en.2004-0921
  15. I. S. Yoo, "The study of health care utilization and direct medical cost in the diabetes melliuts client," The journal of the convergence on culture technology, Vol. 1, No. 4, pp. 87-91, Nov 2015. https://doi.org/10.17703/JCCT.2015.1.4.87
  16. L. Khamzina, A. Veilleux, S. Bergeron and A. Marette, "Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance," Endocrinology, Vol. 146, No. 3, pp. 1473-1481, Mar 2005. https://doi.org/10.1210/en.2004-0921
  17. S. H. Um, F. Frigerio, M. Watanabe, F. Picard, M. Joaquin, M. Sticker, S. Fumagalli, P. R. Allegrini, S. C. Kozma, J. Auwerx and G. Thomas, "Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity," Nature, Vol. 431, No. 7005, pp. 200-205, Sep 2004. https://doi.org/10.1038/nature02866
  18. S. Y. Tsai, A. A. Rodriguez, S. G. Dastidar, E. Del Greco, K. L. Carr, J. M. Sitzmann, E. C. Academia, C. M. Viray, L. L. Martinez, B. S. Kaplowitz, T. D. Ashe, A. R. La Spada and B. K. Kennedy, "Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice," Cell reports, Vol. 16, No. 7, pp. 1903-1914, Aug 2016. https://doi.org/10.1016/j.celrep.2016.07.029
  19. T. H. Reynolds 4th1, N. Cinquino, M. Anthony, C. B. Phelps and E. Zachary Berk, "Insulin resistance without elevated mammalian target of rapamycin complex 1 activity in muscles of mice fed a high-fat diet," Journal of applied physiology, Vol. 107, No. 5, pp. 1479-1485, Nov 2009. https://doi.org/10.1152/japplphysiol.00574.2009
  20. P. Wang, C. Su, H. Feng, X. Chen, Y. Dong, Y. Rao, Y. Ren, J. Yang, J. Shi, J. Tian and S. Jiang, "Curcumin regulates insulin pathways and glucose metabolism in the brains of APPswe/PS1dE9 mice," International journal of immunopathology and pharmacology, Vol. 30, No. 1, pp. 25-43, Mar 2017. https://doi.org/10.1177/0394632016688025
  21. L. Ding, J. Li, B. Song, X. Xiao, B. Zhang, M. Qi, W. Huang, L. Yang and Z. Wang, "Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway," Toxicology and applied pharmacology, Vol. 304, pp. 99-109, Aug 2016. https://doi.org/10.1016/j.taap.2016.05.011
  22. T. C. Cheng, C. S. Lin, C. C. Hsu, L. J. Chen, K. C. Cheng and J. T. Cheng, "Activation of muscarinic M-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from Wistar rats," Neuroscience letters, Vol. 465, No. 3, pp. 238-241, Nov 2009. https://doi.org/10.1016/j.neulet.2009.09.012
  23. M. Kanitkar, K. Gokhale, S. Galande and R. R. Bhonde, "Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo," British journal of pharmacology, Vol. 155, No. 5, pp. 702-713, Nov 2008. https://doi.org/10.1038/bjp.2008.311
  24. L. X. Na, Y. Li, H. Z. Pan, X. L. Zhou, D. J. Sun, M. Meng, X. X. Li and C. H. Sun, "Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial," Molecular nutrition and food research, Vol. 57, No. 9, pp. 1569-1577, Sep 2013. https://doi.org/10.1002/mnfr.201200131
  25. S. Chuengsamarn, S. Rattanamongkolgul, R. Luechapudiporn, C. Phisalaphong and S. Jirawatnotai, "Curcumin extract for prevention of type 2 diabetes," Diabetes Care. Vol. 35, No. 11, pp. 2121-2127, Nov 2012. https://doi.org/10.2337/dc12-0116
  26. M. Tang, D. E. Larson-Meyer and M. Liebman, "Effect of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and plasma glucose in healthy subjects," The American journal of clinical nutrition, Vol. 87, No. 5, pp. 1262-2167, May 2008. https://doi.org/10.1093/ajcn/87.5.1262