Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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Seasonal Variations of Exposure to Environmental Chemicals: Implication from the Korean National Environmental Health Survey (2012-2014)

환경오염물질 노출수준의 계절적 변이와 그 함의 - 제2기 국민환경보건기초조사(2012-2014)

  • Hwang, Moon-Young (Environmental Health Research Division, National Institute of Environmental Research) ;
  • Ryu, Jung-Min (Environmental Health Research Division, National Institute of Environmental Research) ;
  • Kown, Young-Min (Environmental Health Research Division, National Institute of Environmental Research) ;
  • Hong, Soo-Yeon (Environmental Health Research Division, National Institute of Environmental Research) ;
  • Park, Choong-Hee (Environmental Health Research Division, National Institute of Environmental Research)
  • 황문영 (국립환경과학원, 환경건강연구부) ;
  • 류정민 (국립환경과학원, 환경건강연구부) ;
  • 권영민 (국립환경과학원, 환경건강연구부) ;
  • 홍수연 (국립환경과학원, 환경건강연구부) ;
  • 박충희 (국립환경과학원, 환경건강연구부)
  • Received : 2018.11.30
  • Accepted : 2018.12.20
  • Published : 2018.11.28
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Abstract

Objectives: Human biomonitoring (HBM) is a measurement of the chemicals and their metabolites in human biological samples and has been successfully employed to determine the exposure levels of environmental chemicals. In this study, we analyzed seasonal variations of the blood or urinary levels of chemicals, and assessed that these differences could affect the results of association study. Methods: The Korea National Environmental Health Survey (KoNEHS) is a nationwide survey that analyzes exposure levels of environmental pollutants, 19 kinds of chemicals including heavy metals and organic chemicals, and the exposure factors in the general population. Based on KoNEHS data, we analyzed the levels of chemicals concentrations over the total survey period (2012-2014) and each season, and assessed the association of thyroid measures with phthalate metabolite and BPA. Results: Exposure levels of blood mercury and lead were lower in summer compare to winter. Bisphenol A and PAHs metabolites were higher in spring and summer, but lower in autumn. VOCs metabolites were generally lower in summer and autumn. Phthalate metabolites were higher in all other seasons than in winter. Pyrethroid metabolite, 3-PBA, was higher in summer and autumn. Regarding seasonal variation of chemical exposures, the statistical significance and size of effects between thyroid measures and phthalate and BPA were changed with season. Conclusion: Seasonal variations of chemical exposure and health outcome should be considered for interpreting biomonitoring results from a public health context.

Keywords

References

  1. National Research Council, 2006. Human biomonitoring for environmental chemicals. In: Committee on Human Biomonitoring for Environmental Toxicants. The National Academies Press, Washington, DC.
  2. Angerer, J., Bolt, HM., Bruning, T., Drexler, H., Eikmann, T., Ewers, U., Gieler, U., Greim, H., Hallier, E., Letzel, S., Mersch-Sundermann, V.H., Neuberger, M., Nowak, D., Rudiger, H.W., 2004. Uber das Biological Monitoring, den Unwillen Gesundheitsrisiken rational abzuschatzen und die Lust an radikalen Massnahmen. Umweltmed. Forsch. Prax. 9, 61-64.
  3. Hays SM, Becker RA, Leung HW, Aylward LL, Pyatt DW. 2007. Biomonitoring equivalents: A screening approach for interpreting biomonitoring results from a public health risk perspective. Regulatory Toxicol & Parmarcol. 47: 96-109. https://doi.org/10.1016/j.yrtph.2006.08.004
  4. Angerer, J., Bird, M.G., Burke, T.A., Doerrer, N.G., Needham, L., Robison, S.H., Sheldon, L., Zenick, H., 2006. Meeting Report: Strategic Biomonitoring Initiatives: Moving the Science Forward. Toxicol. Sci. published online June 19th, 2006, doi:10.1093/toxsci/kfl042.
  5. Kommission Human-Biomonitoring des Umweltbundesamtes, 1996. Human-biomonitoring: Definitionen, Moglichkeiten und Voraussetzungen. Bundesgesundheitsbl 39, 213-214.
  6. CDC (Centers for Disease Control and Prevention). 2015. Fourth National Report on Human Exposure to Environmental Chemicals, Update Tables. Washington, DC: CDC.
  7. Health Canada. 2013. Second Report on Human Biomonitoring of Environmental Chemicals in Canada: Results of the Canadian Health Measures Survey Cycle 2 (2009-2011).
  8. 박충희, 유승도. 2014. 국민환경보건기초조사의 현황 및 전망. 한국환경보건학회지. 40(1): 1-9. https://doi.org/10.5668/JEHS.2014.40.1.1
  9. Park CH, Hwang MY, Kim HJ, Ryu SD, Lee KJ, Choi KH, Paek DM. 2016. Early snapshot on exposure to environmental chemicals among Korea adults- results of the first Korean National Environmental Health Survey (2009-2011). Int J. Hyg Environ Health. 219: 398-404. https://doi.org/10.1016/j.ijheh.2016.04.001
  10. Masih A, Lall AS, Taneja A, Singhvi R. 2017. Exposure profiles, seasonal variation and health risk assessment of BTEX in indoor air of homes at different microenvironment of a terai province of northern India. Chemosphere. 176: 8-17. https://doi.org/10.1016/j.chemosphere.2017.02.105
  11. Smith MN, Workman T, McDonald KM, et al. Seasonal and occupational trends of five organophosphate pesticides in house dust. J Expo Sci Environ Epidemiol. 2016; 27:372-378.
  12. Weiss L, Arbuckle TE, Fisher M, et al. Temporal variability and sources of triclosan exposure in pregnancy. Int J Hyg Environ Health. 2015; 218: 507-513. https://doi.org/10.1016/j.ijheh.2015.04.003
  13. Wu L, Zhou X, Zhao D, Feng T, Zhou J, Wang TSJ, Wang C. 2017. Seasonal variation and exposure risk assessment of pesticide residues in vegetables from Xinjiang Uygur Autonomous Region of China during 2010-2014. J Food Composition and Analysis. 58: 1-9. https://doi.org/10.1016/j.jfca.2016.12.025
  14. Behall KM, Scolfield DJ, Hallfrisch JG, Kelsay JL, Reiser S. 1984. Seasonal variation in plasma glucose and hormone levels in adult men and women. Am J Clin Nutri. 1352-1356.
  15. Lips P, Hackeng L, Jongen MJM, Van Ginkel FC, Netelenbos JC. 1983. Seasonal variation in serum concentrations of parathyroid hormone in elderly people. J Clin Endocrinol and Metabol. 204-206.
  16. Roberto S, Giancarlo C, Michele B, Guido G, Luisa SL, Alberto Z, Guiseppe O. 1998. Seasonal variations in home and ambulatory blood pressure in the PAMELA population.
  17. Romano ME, Kalloo G, Etzel T, Braun JM. 2017. Seasonal variation in exposure to endocrine-disrupting chemicals. Epidemiology. 28(5): e42-e43. https://doi.org/10.1097/EDE.0000000000000696
  18. Choi WH, Kim SJ, Baek YW, Choi KH, Lee KJ, Kim SK, Yu SD, Choi KH. 2017. Exposure to environmental chemicals among Korean adults-updates from the second Korean National Environmental Health Survey (2012-2014). Int. J. Hyg. Environ. Health 220: 29-35.
  19. Park CH, Choi WH, Hwang MY, Lee YM. Kim SJ, Ryu SD, Lee IA, Paek DM, Choi KH. 2017. Association between urinary phthalate metabolites and bisphenol A levels, and thyroid hormones among Korean adults population-Korean National Environmental Health Survey (KoNEHS) 2012-2014. Sci. Total Environ. 584-585: 950-957. https://doi.org/10.1016/j.scitotenv.2017.01.144
  20. Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL. 2005. Urinary creatinine concentrations in the U.S. population: implication for urinary biologic monitoring measurements. Environ Health Perspect. 113: 192-200. https://doi.org/10.1289/ehp.7337
  21. Lakind JS, Sobus JR, Goodman M, Barr DB, Furst P, Albertini RJ, Arbuckle TE, Schoeters G, Tan YM, Teeguarden J, Tornero-Velez R, Weisel CP. 2014. A proposal for assessing study quality: Biomonitoring, Environmental Epidemiology, and Short-lived Chemicals (BEES-C) instrument. Environ Int. 73, 195-207. https://doi.org/10.1016/j.envint.2014.07.011
  22. 질병관리본부. 2017. 계절에 따른 식품 및 영양소 섭취 현황. 주간 건강과 질병. 제10권. 49호: 1333-1337.
  23. Engstrom A, Michaelsson K, Suwanzono Y, Wolk A, Vahter M, Akesson A. 2011. Long-term cadmium exposure and the association with bone mineral density and factures in a population-based study among women. J Bone & Mineral Reseach. 26(3): 486-495. https://doi.org/10.1002/jbmr.224
  24. 강공언, 김남송, 신은상. 2011. 익산지역 대기 중 PM10과 PM2.5의 계절별 특성. 한국환경보건학회지 37: 29-43.
  25. Lee BK and Hieu NT. 2011. Seasonal variation and sources of heavy metals in atmospheric aerosols in a residential area of Ulsan, Korea. Aerosol and air Quality Research. 11: 679-688. https://doi.org/10.4209/aaqr.2010.10.0089
  26. Ho KF, Lee SC, Guo H, Tsai WY. 2004. Seasonal and diurnal variations of volatile organic compounds (VOCs) in the atmosphere of Hong Kong. Sci of Tot Environ. 332: 155-166. https://doi.org/10.1016/j.scitotenv.2004.04.021
  27. Erythropel HC, Maric M, Nicell JA, Leask RL, Yargeau V. 2014. Leaching of the plasticizer di(2-ethylhexyl) phthalate (DEHP) from plastic containers and the question of human exposure. Appl Microbiol Biotechnol. 98: 9967-9981. https://doi.org/10.1007/s00253-014-6183-8
  28. Heudorf U, Mersch-Sundermann V, Angerer J. 2007. Phthalate: Toxicology and exposure. Int J. Hyg Environ Health. 210: 623-634. https://doi.org/10.1016/j.ijheh.2007.07.011
  29. lee JY, Shin HJ, Bae SY, Kim YP, Kang CH. 2008. Seasonal variation of particulate size distributions of PAHs at Seoul, Korea. Air Qual Atmos Health. 1: 57-68. https://doi.org/10.1007/s11869-008-0002-2
  30. Martorell I, Nieto A, Nadia M, Perello G, Marce RM, Domingo JL. 2012. Human exposure to polycyclic aromatic hydrocarbons (PAHs) using data from a duplicate diet study in Catalonia, Spain. Food and Chem Toxicol. 50(11): 4103-4108. https://doi.org/10.1016/j.fct.2012.08.011
  31. Imai K, Yoshinaga J, Yoshikane M, Shiraishi H, Mieno MN, Yoshiike M, Nozawa S, Iwamoto T. 2014. Pyrethroid insecticide exposure and semen quality of young Japanese men. Reprod Toxicol 43:38-44. doi:10.1016/j.reprotox.2013.10.010
  32. Saillenfait AM, Ndiaye D, Sabate JP. 2015. Pyrethroids: Exposure and health effects-An update. Int J Hyg Environ Health. 218: 281-292. https://doi.org/10.1016/j.ijheh.2015.01.002
  33. Hays SM, Aylward L, Lakind JS. 2007. Introduction to the Biomonitoring Equivalents pilot projects: Development of quidlines for the derivation and communication of Biomonitoring Equivalents. Regul Toxicol and Phramacol. 47: 96-109. https://doi.org/10.1016/j.yrtph.2006.08.004