Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Behaviour of Nanoemulsions Containing Ceramide IIIB and Stratum Corneum Lipids

세라마이드 IIIB와 각질층 지질을 함유한 나노에멀젼의 거동

  • Cho, Wan Goo (Dept. of Functional Foods & Biotechnology, College of Medical Science, Jeonju University) ;
  • Kim, Kyung Ah (Dept. of Functional Foods & Biotechnology, College of Medical Science, Jeonju University) ;
  • Jang, Seon Il (Dept. of Healthcare & Science, Jeonju University) ;
  • Cho, Byoung Ok (Dept. of Healthcare & Science, Jeonju University)
  • 조완구 (전주대학교 의과학대학 바이오기능성식품학과) ;
  • 김경아 (전주대학교 의과학대학 바이오기능성식품학과) ;
  • 장선일 (전주대학교 의과학대학 보건관리학과) ;
  • 조병옥 (전주대학교 의과학대학 보건관리학과)
  • Received : 2018.02.23
  • Accepted : 2018.03.07
  • Published : 2018.03.31
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Abstract

Oil/water (O/W) nanoemulsions are effective vehicles to change the permeability of the skin. In this study, we focused on the preparation and characterization of nanoemulsion which serve as colloidal carriers for the dermal application of ceramide IIIB (CIIIB) and stratum corneum (SC) lipids such as cholesterol, and palmitic acid. In order to optimize the nanoemulsions, emulsification process conditions were conducted with regard to droplet size, nanoemulsion stability, and solubility of CIIIB. A decrease in droplet size was observed through emulsification temperature of $80^{\circ}C$ and phase inversion composition (PIC) method. CIIIB has low solubility in oil and water. When the concentration of CIIIB was increased, the droplet size of nanoemulsion was increased. When Lipoid S75-3 was added to the oil phase, the solubility of CIIIB increased, indicating some interactions shown in DSC measurements. CIIIB and SC lipids could be successfully incorporated in nanoemulsions without crystallization or physical instability. In conclusion, a stable nanoemulsion containing the SC lipids could be effective as an efficient moisturizing system for skin.

오일/정제수(O/W) 나노에멀젼은 피부의 투과성을 변화시키는 효과적인 매개체이다. 본 연구에서 우리는 콜레스테롤, 팔미틴산과 같은 피부 각질층 지질과 세라마이드 IIIB (CIIIB)의 피부 적용을 위한 콜로이드성 운반체 역할을 하는 나노에멀젼의 제조와 특성화에 초점을 두었다. 나노에멀젼을 최적화하기 위해, 입자 크기, 나노에멀젼 안정성 및 CIIIB의 용해도와 관련하여 유화 공정 조건을 검토하였다. $80^{\circ}C$의 유화 온도 및 PIC (phase inversion composition) 유화법을 통해 입자 크기의 감소가 관찰되었다. CIIIB는 오일 및 물에 대한 용해도가 낮다. CIIIB의 농도가 증가하면 나노 에멀젼의 입자 크기가 증가하였다. Lipoid S75-3을 오일 상에 첨가하면 CIIIB의 용해도가 증가하여 DSC 측정에서 보여지는 일부 상호 작용을 나타냈다. CIIIB와 피부 각질층 지질은 결정화 또는 물리적 불안정성 없이 성공적으로 나노 에멀젼에 혼입될 수 있었다. 결론적으로, 피부 각질층 지질을 함유하는 안정한 나노 에멀젼은 피부를 위한 효과적인 보습 시스템으로서 효과적일 수 있다.

Keywords

References

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