Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Comparison of Clinical Characteristics and Severity of Glyphosate and Glufosinate Herbicide Poisoning Patients

Glyphosate와 Glufosinate 제초제 중독 환자의 임상양상과 중증도 비교

  • Joo, Hyung Sun (Department of Emergency Medicine, College of Medicine, Chosun University) ;
  • Yoo, Tae Ho (Department of Emergency Medicine, College of Medicine, Chosun University) ;
  • Cho, Soo Hyung (Department of Emergency Medicine, College of Medicine, Chosun University)
  • 주형선 (조선대학교 의과대학 응급의학교실) ;
  • 유태호 (조선대학교 의과대학 응급의학교실) ;
  • 조수형 (조선대학교 의과대학 응급의학교실)
  • Received : 2018.08.01
  • Accepted : 2018.10.15
  • Published : 2018.12.31
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Abstract

Purpose: The number of glyphosate and glufosinate intoxication cases are increasing in Korea. This study was undertaken is to compare the clinical manifestations of poisoning by these two herbicides and to document severities and clinical outcomes. Methods: We retrospectively evaluated cases of glyphosate or glufosinate intoxication among patients that visited our emergency department between January 1, 2013, and December 31, 2017. Incidences of intoxications were analyzed over this five year period, and underlying diseases, transportation, mental state, shock occurrence, inotropics, gastric lavage, charcoal administration, intubation and ventilator therapy, and hemodialysis were investigated. In addition, we included transfer to the intensive care unit, incidences of pneumonia and of other complications, death, and hopeless discharge. Results: There were 119 cases of glyphosate intoxication and 42 of glufosinate intoxication. Levels of consciousness were lower for glufosinate and vasopressor usage was higher due to a high shock rate (p=0.019). In addition, many patients were referred to the ICU for intubation and ventilation. The incidences of pneumonia and of other complications were significantly higher for glufosinate. Conclusion: Overall glufosinate intoxication was found to be more severe than glyphosate intoxication as determined by complication and ICU admission rates.

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References

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