The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Xuefuzhuyu Decoction for Essential Hypertension: Meta-Analysis and Systemic Review

혈부축어탕의 본태성 고혈압에 대한 치료 효과 관한 메타 분석 및 체계적 고찰

  • Han, In-sik (Dept. of Korean Internal Medicine, College of Korean Medicine, Sang-Ji University) ;
  • Jang, In-soo (Dept. of Korean Internal Medicine, College of Korean Medicine, Woo-Suk University) ;
  • Sun, Seung-ho (Dept. of Korean Internal Medicine, College of Korean Medicine, Sang-Ji University)
  • 한인식 (상지대학교 한의과대학 한방내과학교실) ;
  • 장인수 (우석대학교 한의학대학 한방내과학교실) ;
  • 선승호 (상지대학교 한의과대학 한방내과학교실)
  • Received : 2018.11.19
  • Accepted : 2018.12.31
  • Published : 2018.12.30
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Abstract

Objective: The purpose of this study was to investigate the effect reducing blood pressure (BP) using Xuefuzhuyu Decoction (XFZYD) in adults with essential hypertension (EH). Method: Search engine, such as PubMed, EMBASE, Cochrane library, Web of Science, J-STAGE, CiNii, CNKI, OASIS, NDSL, KISS, RISS, and DBpia, were used. The search period was from the beginning of the search engine to June 30, 2018 and there were no limits regarding languages. The selection and extraction of literatures were performed independently by two authors. Meta-analysis was done on the total effective rate (TER), Systolic BP (SBP) and Diastolic BP (DBP). Cochrane's risk of bias (ROB) was used as the methodological quality assessment scale. Results: Twenty studies were finally selected. We observed that a combination treatment using XFZYD and an antihypertensive drug (AHD) was 5.1 times more effective in lowering BP than using AHD alone on TER. The mean differences in SBP and DBP were -10.65 mmHg (95% Confidential Interval (CI) -13.55 mmHg, -7.74 mmHg, P<0.00001), -5.92 mmHg (95% CI -7.14, -4.38, P<0.00001), respectively. Conclusion: A combination treatment using XFZYD and AHD may be more effective in reducing BP than using AHD alone. Because of the poor methodological quality of the studies conducted thus far, high-quality clinical trials will be required in the future.

Keywords

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