The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Effect of Red Ginseng on Sarcopenic Rat

홍삼의 Dexamethasone 유도 근감소증 모델 백서에 대한 효과 연구

  • Seo, Yoon-jeong (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Lew, Jae-hwan (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung Hee University)
  • 서윤정 (경희대학교 한의과대학 내과학교실) ;
  • 류재환 (경희대학교 한의과대학 내과학교실)
  • Received : 2018.11.26
  • Accepted : 2018.12.27
  • Published : 2018.12.30
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Abstract

Objective: As the number of sarcopenic patients worldwide is increasing, the need for the treatment of sarcopenia is increasing. Ginseng has been reported to be a major herbal supplement. We tested whether red ginseng would be effective for sarcopenia using red ginseng preparation which can be easily obtained locally in Korea. Methods: 30 rats were randomly divided into three groups: the control group (n=10) (Group C), the group with Dexamethasone -induced sarcopenia (n=10) (Group D), and the group to which red ginseng was administered group after induced sarcopenia with Dexamethasone (n=10) (Group DH). Dexamethasone was intraperitoneally administered to group D and group DH for 7 days to make sarcopenic model. After that, the red ginseng tablets prepared by Korea Ginseng Corporation were diluted in distilled water and administered orally to the DH group for 2 weeks. Body weight and grip strength were measured 8 times during the experiment. At the end of the experiment, blood was collected by cardiac puncture. In addition, the tibialis muscle was extracted, a myofibril cross section was measured by immunohistochemical staining and MyHC (myosin heavy chain) was quantified by Western blotting. Results: The ratio of the area on myofibril cross-section showed significant differences after administration of the red ginseng tablet. Conclusions: Red ginseng has a significant effect on the recovery of myofibril cross-section on sarcopenia. This experiment will be helpful for future clinical studies on drug effects in sarcopennia.

Keywords

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