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Current Issues in Adolescent Varicocele: Pediatric Urological Perspectives

  • Chung, Jae Min (Department of Urology, Pusan National University School of Medicine) ;
  • Lee, Sang Don (Department of Urology, Pusan National University School of Medicine)
  • Received : 2017.11.02
  • Accepted : 2018.01.03
  • Published : 2018.05.01

Abstract

While varicocele is the most common cause of surgically correctable infertility in adult males, with repair resulting in improved semen parameters in 60% to 80% of men and a higher likelihood of conception in up to 60% of men, the rationale for varicocele repair in the pediatric population is less clear. Additionally, prepubertal varicoceles are much less common and their management is controversial. Adolescents with a varicocele are often in the midst of a progressive disease process. Despite the high prevalence of varicocele and its association with progressive disease processes, the indications for adolescent varicocele repair and the effects thereof on paternity have been persistently challenging to study. This review will briefly present some of the current issues regarding adolescent varicocele from a pediatric urological point of view, including the evaluation of adolescent varicocele, the optimal surgical indications, the optimal choice of surgical intervention to be performed, and outcomes.

Keywords

Acknowledgement

Supported by : Pusan National University Yangsan Hospital

References

  1. Agarwal A, Deepinder F, Cocuzza M, Agarwal R, Short RA, Sabanegh E, et al. Efficacy of varicocelectomy in improving semen parameters: new meta-analytical approach. Urology 2007;70:532-8. https://doi.org/10.1016/j.urology.2007.04.011
  2. Goldstein M. Surgical management of male infertility. In: Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA, editors. Campbell-Walsh urology. Philadelphia: Elsevier Saunders; 2012;648-87.
  3. Chiba K, Ramasamy R, Lamb DJ, Lipshultz LI. The varicocele: diagnostic dilemmas, therapeutic challenges and future perspectives. Asian J Androl 2016;18:276-81. https://doi.org/10.4103/1008-682X.167724
  4. Akbay E, Cayan S, Doruk E, Duce MN, Bozlu M. The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. BJU Int 2000;86:490-3. https://doi.org/10.1046/j.1464-410X.2000.00735.x
  5. Kumanov P, Robeva RN, Tomova A. Adolescent varicocele: who is at risk? Pediatrics 2008;121:e53-7. https://doi.org/10.1542/peds.2007-0340
  6. Zampieri N, Cervellione RM. Varicocele in adolescents: a 6-year longitudinal and followup observational study. J Urol 2008;180(4 Suppl):1653-6. https://doi.org/10.1016/j.juro.2008.03.114
  7. Sayfan J, Siplovich L, Koltun L, Benyamin N. Varicocele treatment in pubertal boys prevents testicular growth arrest. J Urol 1997;157:1456-7. https://doi.org/10.1016/S0022-5347(01)65021-3
  8. Shen JK, Huang GO, Ko EY. Controversies in varicocele repair: much ado about nothing? Asian J Androl 2016;18:317-8. https://doi.org/10.4103/1008-682X.168789
  9. Glassberg KI, Korets R. Update on the management of adolescent varicocele. F1000 Med Rep 2010;2:25. doi: 10.3410/M2-25.
  10. Mehta A, Goldstein M. Microsurgical varicocelectomy: a review. Asian J Androl 2013;15:56-60. https://doi.org/10.1038/aja.2012.98
  11. Kadyrov ZA, Teodorovich OV, Zokirov OO, Ishonakov KhS, Muminov NO. Bilateral varicocele: epidemiology, clinical presentation and diagnosis. Urologiia 2007;(3):64-8.
  12. Diamond DA, Gargollo PC, Caldamone AA. Current management principles for adolescent varicocele. Fertil Steril 2011;96:1294-8. https://doi.org/10.1016/j.fertnstert.2011.10.034
  13. Dubin L, Amelar RD. Varicocele size and results of varicocelectomy in selected subfertile men with varicocele. Fertil Steril 1970;21:606-9. https://doi.org/10.1016/S0015-0282(16)37684-1
  14. Glassberg KI. My indications for treatment of the adolescent varicocele (and why?). Transl Androl Urol 2014;3:402-12.
  15. Diamond DA, Zurakowski D, Bauer SB, Borer JG, Peters CA, Cilento BG Jr, et al. Relationship of varicocele grade and testicular hypotrophy to semen parameters in adolescents. J Urol 2007;178:1584-8. https://doi.org/10.1016/j.juro.2007.03.169
  16. Masson P, Brannigan RE. The varicocele. Urol Clin North Am 2014;41:129-44. https://doi.org/10.1016/j.ucl.2013.08.001
  17. Vasavada S, Ross J, Nasrallah P, Kay R. Prepubertal varicoceles. Urology 1997;50:774-7. https://doi.org/10.1016/S0090-4295(97)00332-4
  18. Roque M, Esteves SC. A systematic review of clinical practice guidelines and best practice statements for the diagnosis and management of varicocele in children and adolescents. Asian J Androl 2016;18:262-8. https://doi.org/10.4103/1008-682X.169559
  19. Sakamoto H, Ogawa Y, Yoshida H. Relationship between testicular volume and testicular function: comparison of the Prader orchidometric and ultrasonographic measurements in patients with infertility. Asian J Androl 2008;10:319-24. https://doi.org/10.1111/j.1745-7262.2008.00340.x
  20. Diamond DA, Paltiel HJ, DiCanzio J, Zurakowski D, Bauer SB, Atala A, et al. Comparative assessment of pediatric testicular volume: orchidometer versus ultrasound. J Urol 2000; 164:1111-4. https://doi.org/10.1016/S0022-5347(05)67264-3
  21. Kurtz MP, Migliozzi M, Rosoklija I, Zurakowski D, Diamond DA. Accuracy of orchidometry in boys with varicocele. J Pediatr Urol 2015;11:185.e1-5. https://doi.org/10.1016/j.jpurol.2015.02.011
  22. Esteves SC, Agarwal A. Afterword to varicocele and male infertility: current concepts and future perspectives. Asian J Androl 2016;18:319-22. https://doi.org/10.4103/1008-682X.172820
  23. Coutinho K, McLeod D, Stensland K, Stock JA. Variations in the management of asymptomatic adolescent grade 2 or 3 left varicoceles: a survey of practitioners. J Pediatr Urol 2014;10: 430-4. https://doi.org/10.1016/j.jpurol.2013.11.001
  24. Lee TH, Jung JH, Hong YK. Diagnosis and management of pediatric and adolescent varicocele: a survey of pediatric urologists in Korea. Chonnam Med J 2016;52:207-11. https://doi.org/10.4068/cmj.2016.52.3.207
  25. Chu DI, Zderic SA, Shukla AR, Srinivasan AK, Tasian GE, Weiss DA, et al. The natural history of semen parameters in untreated asymptomatic adolescent varicocele patients: A retrospective cohort study. J Pediatr Urol 2017;13:77.e1-77.e5. https://doi.org/10.1016/j.jpurol.2016.09.008
  26. Rajfer J. Varicoceles: practice guidelines. Rev Urol 2007;9:161.
  27. de Los Reyes T, Locke J, Afshar K. Varicoceles in the pediatric population: Diagnosis, treatment, and outcomes. Can Urol Assoc J 2017;11:S34-9. https://doi.org/10.5489/cuaj.4340
  28. Tanrikut C, Goldstein M, Rosoff JS, Lee RK, Nelson CJ, Mulhall JP. Varicocele as a risk factor for androgen deficiency and effect of repair. BJU Int 2011;108:1480-4. https://doi.org/10.1111/j.1464-410X.2010.10030.x
  29. Trost LW, Mulhall JP. Challenges in testosterone measurement, data interpretation, and methodological appraisal of interventional trials. J Sex Med 2016;13:1029-46. https://doi.org/10.1016/j.jsxm.2016.04.068
  30. Choi WS, Kim SW. Current issues in varicocele management: a review. World J Mens Health 2013;31:12-20. https://doi.org/10.5534/wjmh.2013.31.1.12
  31. Moursy EE, ElDahshoury MZ, Hussein MM, Mourad MZ, Badawy AA. Dilemma of adolescent varicocele: long-term outcome in patients managed surgically and in patients managed expectantly. J Pediatr Urol 2013;9:1018-22. https://doi.org/10.1016/j.jpurol.2013.01.017
  32. Richter F, Stock JA, LaSalle M, Sadeghi-Nejad H, Hanna MK. Management of prepubertal varicoceles-results of a questionnaire study among pediatric urologists and urologists with infertility training. Urology 2001;58:98-102. https://doi.org/10.1016/S0090-4295(01)01118-9
  33. Practice Committee of the American Society for Reproductive Medicine. Report on varicocele and infertility. Fertil Steril 2006;86:S93-5.
  34. Pastuszak AW, Kumar V, Shah A, Roth DR. Diagnostic and management approaches to pediatric and adolescent varicocele: a survey of pediatric urologists. Urology 2014;84:450-5. https://doi.org/10.1016/j.urology.2014.04.022
  35. Decastro GJ, Shabsigh A, Poon SA, Laor L, Glassberg KI. Adolescent varicocelectomy: is the potential for catch-up growth related to age and/or Tanner stage? J Urol 2009;181:322-7.
  36. Resorlu B, Kara C, Sahin E, Unsal A. The significance of age on success of surgery for patients with varicocele. Int Urol Nephrol 2010;42:351-6. https://doi.org/10.1007/s11255-009-9589-y
  37. Laven JS, Haans LC, Mali WP, te Velde ER, Wensing CJ, Eimers JM. Effects of varicocele treatment in adolescents: a randomized study. Fertil Steril 1992;58:756-62. https://doi.org/10.1016/S0015-0282(16)55324-2
  38. Jungwirth A, Giwercman A, Tournaye H, Diemer T, Kopa Z, Dohle G, et al. European Association of Urology guidelines on male infertility: the 2012 update. Eur Urol 2012;62:324-32. https://doi.org/10.1016/j.eururo.2012.04.048
  39. Bogaert G, Orye C, De Win G. Pubertal screening and treatment for varicocele do not improve chance of paternity as adult. J Urol 2013;189:2298-303. https://doi.org/10.1016/j.juro.2012.12.030
  40. Van Batavia JP, Woldu SL, Raimondi PM, Spencer BA, Insel BJ, Poon SA, et al. Adolescent varicocele: influence of Tanner stage at presentation on the presence, development, worsening and/or improvement of testicular hypotrophy without surgical intervention. J Urol 2010;184(4 Suppl):1727-32. https://doi.org/10.1016/j.juro.2010.05.053
  41. Paduch DA, Niedzielski J. Repair versus observation in adolescent varicocele: a prospective study. J Urol 1997;158:1128-32. https://doi.org/10.1016/S0022-5347(01)64403-3
  42. Cayan S, Akbay E, Bozlu M, Doruk E, Erdem E, Acar D, et al. The effect of varicocele repair on testicular volume in children and adolescents with varicocele. J Urol 2002;168:731-4. https://doi.org/10.1016/S0022-5347(05)64735-0
  43. Sathya Srini V, Belur Veerachari S. Does varicocelectomy improve gonadal function in men with hypogonadism and infertility? Analysis of a prospective study. Int J Endocrinol 2011. doi: 10.1155/2011/916380.
  44. Harel M, Herbst KW, Nelson E. Practice patterns in the surgical approach for adolescent varicocelectomy. Springerplus 2015;4:772. https://doi.org/10.1186/s40064-015-1573-7
  45. Kass EJ, Belman AB. Reversal of testicular growth failure by varicocele ligation. J Urol 1987;137:475-6. https://doi.org/10.1016/S0022-5347(17)44072-9
  46. Feber KM, Kass EJ. Varicocelectomy in adolescent boys: longterm experience with the Palomo procedure. J Urol 2008; 180(4 Suppl):1657-9; discussion 1659-60. https://doi.org/10.1016/j.juro.2008.03.099
  47. Sinanoglu O, Eyyupoglu SE, Ekici S. Ipsilateral testicular catch-up growth rate following microsurgical inguinal adolescent varicocelectomy. ScientificWorldJournal 2012. doi:10.1100/2012/356374.
  48. Poon SA, Kozakowski KA, Decastro GJ, Gjertson CK, Glassberg KI. Adolescent varicocelectomy: postoperative catch-up growth is not secondary to lymphatic ligation. J Pediatr Urol 2009;5:37-41. https://doi.org/10.1016/j.jpurol.2008.08.002
  49. Fast AM, Deibert CM, Van Batavia JP, Nees SN, Glassberg KI. Adolescent varicocelectomy: does artery sparing influence recurrence rate and/or catch-up growth? Andrology 2014;2: 159-64. https://doi.org/10.1111/j.2047-2927.2013.00142.x
  50. Li F, Chiba K, Yamaguchi K, Okada K, Matsushita K, Ando M, et al. Effect of varicocelectomy on testicular volume in children and adolescents: a meta-analysis. Urology 2012;79:1340-5. https://doi.org/10.1016/j.urology.2012.02.022
  51. Shiraishi K, Oka S, Matsuyama H. Surgical comparison of subinguinal and high inguinal microsurgical varicocelectomy for adolescent varicocele. Int J Urol 2016;23:338-42. https://doi.org/10.1111/iju.13050
  52. Atassi O, Kass EJ, Steinert BW. Testicular growth after successful varicocele correction in adolescents: comparison of artery sparing techniques with the Palomo procedure. J Urol 1995;153:482-3. https://doi.org/10.1097/00005392-199502000-00065
  53. Chiba K, Fujisawa M. Clinical outcomes of varicocele repair in infertile men: a review. World J Mens Health 2016;34:101-9. https://doi.org/10.5534/wjmh.2016.34.2.101
  54. Nork JJ, Berger JH, Crain DS, Christman MS. Youth varicocele and varicocele treatment: a meta-analysis of semen outcomes. Fertil Steril 2014;102:381-7.e6. https://doi.org/10.1016/j.fertnstert.2014.04.049
  55. Pastuszak AW, Wang R. Varicocele and testicular function. Asian J Androl 2015;17:659-67. https://doi.org/10.4103/1008-682X.153539
  56. Pajovic B, Radojevic N. Prospective follow up of fertility after adolescent laparoscopic varicocelectomy. Eur Rev Med Pharmacol Sci 2013;17:1060-3.
  57. Kim SO, Jung H, Park K. Outcomes of microsurgical subinguinal varicocelectomy for painful varicoceles. J Androl 2012; 33:872-5. https://doi.org/10.2164/jandrol.111.014993
  58. Park HJ, Lee SS, Park NC. Predictors of pain resolution after varicocelectomy for painful varicocele. Asian J Androl 2011; 13:754-8. https://doi.org/10.1038/aja.2010.87
  59. Kim HT, Song PH, Moon KH. Microsurgical ligation for painful varicocele: effectiveness and predictors of pain resolution. Yonsei Med J 2012;53:145-50. https://doi.org/10.3349/ymj.2012.53.1.145
  60. Park YW, Lee JH. Preoperative predictors of varicocelectomy success in the treatment of testicular pain. World J Mens Health 2013;31:58-63. https://doi.org/10.5534/wjmh.2013.31.1.58

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