DOI QR코드

DOI QR Code

Requirement of Establishment of Frozen Blood Storage System for Management of Rare Blood Supply and Strategic National Stockpile

희귀혈액형 수급관리 및 국가 재난대비 혈액비축을 위한 동결혈액보관시스템 구축의 필요성

  • Kim, Jaehyun (Blood Transfusion Research Institute, Korean Red Cross) ;
  • Choi, Kyoung Young (Blood Transfusion Research Institute, Korean Red Cross) ;
  • Youn, Kyoung Won (Blood Transfusion Research Institute, Korean Red Cross) ;
  • Kim, Yeongbin (Blood Transfusion Research Institute, Korean Red Cross) ;
  • Min, Hyuk Ki (Blood Transfusion Research Institute, Korean Red Cross) ;
  • Kim, Hyun Ok (Department of Laboratory Medicine, Yonsei University College of Medicine)
  • 김재현 (대한적십자사 혈액수혈연구원) ;
  • 최경영 (대한적십자사 혈액수혈연구원) ;
  • 윤경원 (대한적십자사 혈액수혈연구원) ;
  • 김영빈 (대한적십자사 혈액수혈연구원) ;
  • 민혁기 (대한적십자사 혈액수혈연구원) ;
  • 김현옥 (연세대학교 의과대학 진단검사의학교실)
  • Received : 2018.01.31
  • Accepted : 2018.03.23
  • Published : 2018.04.30

Abstract

The blood supply can become disrupted in situations of increased demand during unexpected national catastrophes and when a patient needs a rare blood transfusion, which depends on the blood inventory in peacetime. Cryopreservation of blood, which can be stored up to 10 years, represents a possible solution to this problem by avoiding storage lesions. This review describes frozen red cell technologies, quality control issues related to post-thaw red blood cells, and preconditions and practical considerations for implementation of a frozen blood banking system in Korea.

혈액은 예상치 못한 국가 위기상황에서 다량의 혈액이 필요할 때, 또는 평시에 희귀혈액의 수혈이 필요한 환자가 발생하였을 때 혈액재고에 따라 수급이 매우 어려울 수 있다. 이러한 문제에 대한 가능한 해결방법으로 저장과정 중 발생할 수 있는 손상 없이 혈액을 10년까지 보존할 수 있는 동결혈액 보관방법이 있다. 본 종설에서는 적혈구 동결기술, 동결해동적혈구의 품질관리와 동결혈액보관시스템의 국내 도입을 위한 선결과제와 현실적으로 고려해야 할 문제점을 요약하고 고찰하였다.

Keywords

References

  1. Smith AU. Prevention of haemolysis during freezing and thawing of red blood-cells. Lancet 1950;2:910-1
  2. Valeri CR, Runck AH. Long term frozen storage of human red blood cells: studies in vivo and in vitro of autologous red blood cells preserved up to six years with high concentrations of glycerol. Transfusion 1969;9:5-14 https://doi.org/10.1111/j.1537-2995.1969.tb04906.x
  3. Valeri CR, Ragno G, Pivacek LE, Cassidy GP, Srey R, Hansson-Wicher M, et al. An experiment with glycerol-frozen red blood cells stored at -80 degrees C for up to 37 years. Vox Sang 2000;79:168-74 https://doi.org/10.1046/j.1423-0410.2000.7930168.x
  4. Hampton DA, Wiles C, Fabricant LJ, Kiraly L, Differding J, Underwood S, et al. Cryopreserved red blood cells are superior to standard liquid red blood cells. J Trauma Acute Care Surg 2014;77:20-7; discussion 26-7 https://doi.org/10.1097/TA.0000000000000268
  5. Fabricant L, Kiraly L, Wiles C, Differding J, Underwood S, Deloughery T, et al. Cryopreserved deglycerolized blood is safe and achieves superior tissue oxygenation compared with refrigerated red blood cells: a prospective randomized pilot study. J Trauma Acute Care Surg 2013;74:371-6; discussion 376-7 https://doi.org/10.1097/TA.0b013e31827e1d40
  6. Fung MK, Eder A, Spitalnik SL, Westhoff CM; AABB. Technical manual. 19th ed. Bethesda, Maryland: American Association of Blood Banks, 2017:457-88
  7. European Directorate for the Quality of Medicine and HealthCare (EDQM). Guide to the preparation, use and quality assurance of blood components. 19th ed. Strasbourg, France: Council of Europe, 2017:318-23
  8. Valeri CR, Ragno G, Van Houten P, Rose L, Rose M, Egozy Y, et al. Automation of the glycerolization of red blood cells with the high-separation bowl in the Haemonetics ACP 215 instrument. Transfusion 2005;45:1621-7 https://doi.org/10.1111/j.1537-2995.2005.00588.x
  9. Bandarenko N, Hay SN, Holmberg J, Whitley P, Taylor HL, Moroff G, et al. Extended storage of AS-1 and AS-3 leukoreduced red blood cells for 15 days after deglycerolization and resuspension in AS-3 using an automated closed system. Transfusion 2004;44:1656-62 https://doi.org/10.1111/j.1537-2995.2004.04101.x
  10. Bohonek M, Petras M, Turek I, Urbanova J, Hradek T, Chmatal P, et al. Quality evaluation of frozen apheresis red blood cell storage with 21-day postthaw storage in additive solution 3 and saline-adenine-glucose-mannitol: biochemical and chromium-51 recovery measures. Transfusion 2010;50:1007-13
  11. Lagerberg JW, Truijens-de Lange R, de Korte D, Verhoeven AJ. Altered processing of thawed red cells to improve the in vitro quality during postthaw storage at 4 degrees C. Transfusion 2007;47:2242-9 https://doi.org/10.1111/j.1537-2995.2007.01453.x
  12. Sen A, Khetarpal A. Comparative study of automated cryopreservation of red blood cells. Med J Armed Forces India 2013;69:345-50 https://doi.org/10.1016/j.mjafi.2013.06.005
  13. Valeri CR, Ragno G. Cryopreservation of human blood products. Transfus Apher Sci 2006;34:271-87 https://doi.org/10.1016/j.transci.2005.11.010
  14. Lelkens CC, Noorman F, Koning JG, Truijensde Lange R, Stekkinger PS, Bakker JC, et al. Stability after thawing of RBCs frozen with the high- and low-glycerol method. Transfusion 2003;43:157-64 https://doi.org/10.1046/j.1537-2995.2003.00293.x
  15. Szymanski IO, Teno RA, Lockwood WB, Hudgens R, Johnson GS. Effect of rejuvenation and frozen storage on 42-day-old AS-1 RBCs. Transfusion 2001;41:550-5 https://doi.org/10.1046/j.1537-2995.2001.41040550.x
  16. Reid ME, Lomas-Francis C, Olsson M. The blood group antigen factsbook. 3rd ed. New York: Academic Press, 2012:361-6
  17. Nance S, Scharberg EA, Thornton N, Yahalom V, Sareneva I, Lomas-Francis C. International rare donor panels: a review. Vox Sang 2016;110:209-18 https://doi.org/10.1111/vox.12357
  18. Nance ST. How to find, recruit and maintain rare blood donors. Curr Opin Hematol 2009;16:503-8 https://doi.org/10.1097/MOH.0b013e3283316bed
  19. Hong YJ, Chung Y, Hwang SM, Park JS, Kwon JR, Choi YS, et al. Genotyping of 22 blood group antigen polymorphisms and establishing a national recipient registry in the Korean population. Ann Hematol 2016;95:985-91 https://doi.org/10.1007/s00277-016-2645-7
  20. Shinar E, Yahalom V, Silverman BG. Meeting blood requirements following terrorist attacks: the Israeli experience. Curr Opin Hematol 2006;13:452-6 https://doi.org/10.1097/01.moh.0000245691.32085.66
  21. Dann EJ, Bonstein L, Arbov L, Kornberg A, Rahimi-Levene N. Blood bank protocols for large-scale civilian casualty events: experience from terrorist bombing in Israel. Transfus Med 2007;17:135-9 https://doi.org/10.1111/j.1365-3148.2006.00713.x
  22. Hess JR, Thomas MJ. Blood use in war and disaster: lessons from the past century. Transfusion 2003;43:1622-33 https://doi.org/10.1046/j.1537-2995.2003.00576.x
  23. Farion KJ, McLellan BA, Boulanger BR, Szalai JP. Changes in red cell transfusion practice among adult trauma victims. J Trauma 1998;44:583-7 https://doi.org/10.1097/00005373-199804000-00004
  24. Como JJ, Dutton RP, Scalea TM, Edelman BB, Hess JR. Blood transfusion rates in the care of acute trauma. Transfusion 2004;44:809-13 https://doi.org/10.1111/j.1537-2995.2004.03409.x
  25. MDA Blood Services, Israel. Use of blood and blood products in disasters 24-25.11.08, Israel. http://www.mvcr.cz/soubor/blood-final-presentation-pdf.aspx [Online] (last visited on 30 January 2018)
  26. Manning FJ, Sparacino L. Blood donors and the supply of blood and blood products. Washington DC: National Academy Press, 1996:91-7
  27. Spinella PC, Dunne J, Beilman GJ, O'Connell RJ, Borgman MA, Cap AP, et al. Constant challenges and evolution of US military transfusion medicine and blood operations in combat. Transfusion 2012;52:1146-53 https://doi.org/10.1111/j.1537-2995.2012.03594.x
  28. Armed Services Blood Program (ASBP). Frozen red blood cells. ASBP tech. http://www.militaryblood.dod.mil/tech/doc/Frozen_Red_Cell_WP.pdf [Online] (last visited on 30 January 2018)
  29. Erickson ML, Champion MH, Klein R, Ross RL, Neal ZM, Snyder EL. Management of blood shortages in a tertiary care academic medical center: the Yale-New Haven Hospital frozen blood reserve. Transfusion 2008;48:2252-63 https://doi.org/10.1111/j.1537-2995.2008.01816.x
  30. Hess JR. Red cell freezing and its impact on the supply chain. Transfus Med 2004;14:1-8 https://doi.org/10.1111/j.0958-7578.2004.00472.x

Cited by

  1. Case of Acute Hemolytic Transfusion Reaction due to Anti-Fya Alloantibody in a Patient with Autoimmune Hemolytic Anemia vol.29, pp.3, 2018, https://doi.org/10.17945/kjbt.2018.29.3.320
  2. Alloantibodies to High-Incidence Antigen: Review of Cases and Transfusion Experiences in Korea vol.30, pp.2, 2018, https://doi.org/10.17945/kjbt.2019.30.2.101
  3. Anti-PP1Pk (Tja) Antibody in a Korean Female Patient with p Phenotype Confirmed by Genotyping vol.10, pp.1, 2018, https://doi.org/10.3343/lmo.2020.10.1.84