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Psychosocial Factors Influence the Functional Gastrointestinal Disorder among Psychiatric Patients

정신질환자들에 동반된 기능성 위장질환에 영향을 미치는 정신사회적 요인에 관한 연구

  • Kang, Deung-Hyun (Department of Psychiatry, School of Medicine, Wonkwang University) ;
  • Jang, Seung-Ho (Department of Psychiatry, School of Medicine, Wonkwang University) ;
  • Ryu, Han-Seung (Department of Internal Medicine, School of Medicine, Wonkwang University) ;
  • Choi, Suck-Chei (Department of Internal Medicine, School of Medicine, Wonkwang University) ;
  • Rho, Seung-Ho (Department of Psychiatry, School of Medicine, Wonkwang University) ;
  • Paik, Young-Suk (Department of Psychiatry, School of Medicine, Wonkwang University) ;
  • Lee, Hye-Jin (Department of Public Health, Wonkwang University Graduate School) ;
  • Lee, Sang-Yeol (Department of Psychiatry, School of Medicine, Wonkwang University)
  • 강등현 (원광대학교병원 정신건강의학과) ;
  • 장승호 (원광대학교병원 정신건강의학과) ;
  • 류한승 (원광대학교병원 소화기내과) ;
  • 최석채 (원광대학교병원 소화기내과) ;
  • 노승호 (원광대학교병원 정신건강의학과) ;
  • 백영석 (원광대학교병원 정신건강의학과) ;
  • 이혜진 (원광대학교 대학원 보건학과) ;
  • 이상열 (원광대학교병원 정신건강의학과)
  • Received : 2017.10.26
  • Accepted : 2018.03.08
  • Published : 2018.06.30

Abstract

Objectives : This study aimed to investigate the psychosocial characteristics of functional gastrointestinal disorder (FGID) in patients with psychiatric disorders. Methods : This study was conducted with 144 outpatients visiting the psychiatric clinic at a university hospital. FGIDs were screened according to the Rome III questionnaire-Korean version. Demographic factors were investigated, and psychosocial factors were evaluated using the Hospital Anxiety Depression Scale, Patient Health Questionnaire-15, Childhood Trauma Questionnaire-Korean, and State-Trait Anger Expression Inventory. Chisquared test and student's t-test were used as statistical analysis methods. Results : There were differences in education level between two groups divided according to FGID status (${\chi}^2=10.139$, p=0.017). Comparing the psychiatric disorder by FGID group, irritable bowel syndrome (IBS) group showed significant differences (${\chi}^2=11.408$, p=0.022). According to FGID status, IBS group showed significant differences for anxiety (t=-3.106, p=0.002), depressive symptom (t=-2.105, p=0.037), somatic symptom (t=-3.565, p<0.001), trait anger (t=-3.683, p<0.001), anger-in (t=-2.463, p=0.015), and anger-out (t=-2.355, p=0.020). Functional dyspepsia group showed significant differences for anxiety (t=-4.893, p<0.001), depressive symptom (t=-3.459, p<0.001), somatic symptom (t=-7.906, p<0.001), trait-anger (t=-4.148, p<0.001), state-anger (t=-2.181, p=0.031), anger-in (t=-2.684, p=0.008), and anger-out (t=-3.005, p=0.003). Nonerosive reflux disease group showed significant differences for anxiety (t=-4.286, p<0.001), depressive symptom (t=-3.402, p<0.001), somatic symptom (t=-7.162, p<0.001), trait anger (t=-2.994, p=0.003), state anger (t=-2.259, p=0.025), anger-in (t=-2.772, p=0.006), and anger-out (t=-2.958, p=0.004). Conclusions : Patients with psychiatric disorders had a high prevalence of FGID, and various psychosocial factors contributed to such differences. Therefore, the psychiatric approach can offer better understandings and treatments to patients with FGID.

연구목적 본 연구에서는 기능성 위장질환(Functional gastrointestinal disorder, 이하 FGID)이 동반된 정신질환자들의 정신사회적 특성을 알아보고자 하였다. 방 법 일 대학병원 정신건강의학과 외래를 방문한 환자를 대상으로 Rome III questionnaire - Korean version에 따라 FGID를 선별하여 144명의 자료를 분석하였다. 인구학적 요인을 조사하였으며, 정신사회적 요인을 평가하기 위해 Hospital Anxiety Depression Scale, Patient Health Questionnaire-15, Childhood Trauma Questionnaire-Korean, State-Trait Anger Expression Inventory를 사용하였다. 통계분석은 독립표본 t-검정(independent t-test)과 교차분석(chi-square test)을 사용하였다. 결 과 FGID에 따른 집단간 비교에서 학력에 따른 차이가 나타났다(${\chi}^2=10.139$, p=0.017). FGID 집단에 따른 정신질환의 차이에서는 과민성 대장증후군(Irritable bowel syndrome, 이하 IBS) 집단에서 유의한 차이가 있었다. (${\chi}^2=11.408$, p=0.022) IBS 집단은 불안(t=-3.106, p=0.002), 우울증상(t=-2.105, p=0.037), 신체증상(t=-3.565, p<0.001), 특성분노(t=-3.683, p<0.001), 분노-억제(t=-2.463, p=0.015), 분노-표출(t=-2.355, p=0.020)에서 높은 점수를 나타냈다. 기능성 소화불량(Functional dyspepsia) 집단에서는 불안(t=-4.893, p<0.001), 우울증상(t=-3.459, p<0.001), 신체증상(t=-7.906, p<0.001), 특성분노(t=-4.148, p<0.001), 상태분노(t=-2.181, p=0.031), 분노-억제(t=-2.684, p=0.008), 분노-표출(t=-3.005, p=0.003)지표가 유의하게 높았다. 비미란성 위식도 역류증(Nonerosive reflux disease) 집단에서는 불안(t=-4.286, p<0.001), 우울증상(t=-3.402, p<0.001), 신체증상(t=-7.162, p<0.001), 특성분노(t=-2.994, p=0.003), 상태분노(t=-2.259, p=0.025), 분노-억제(t=-2.772, p=0.006), 분노-표출(t=-2.958, p=0.004)에서 유의미하게 높은 수준을 나타냈다. 결 론 본 연구에서는 정신질환자에서 FGID의 유병률이 매우 높고, 다양한 정신사회적 변인들이 이에 영향을 미치는 것으로 나타났다. 따라서 이러한 정신의학적 접근은 FGID 환자를 더 잘 이해하고 치료하는데 있어서 도움이 될 것으로 생각된다.

Keywords

References

  1. Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 2006;130:1377-1390. https://doi.org/10.1053/j.gastro.2006.03.008
  2. Thompson WG, Heaton KW. Functional bowel disorders in apparently healthy people. Gastroenterology 1980;79:283-288.
  3. Mayer EA. Emerging disease model for functional gastrointestinal disorders. Am J Med 1999;107:12-19.
  4. Mayer EA, Tillisch K, Bradesi S. Review article: modulation of the brain-gut axis as a therapeutic approach in gastrointesti- nal disease. Aliment Pharmacol Ther 2006;24:919-933. https://doi.org/10.1111/j.1365-2036.2006.03078.x
  5. Kim DY, Camilleri M. Serotonin: a mediator of the brain-gut connection. Am J Gastroenterol 2000;95:2698-2709.
  6. Creed F. The relationship between psychosocial parameters and outcome in irritable bowel syndrome. Am J Med 1999;107: 74-80.
  7. Kang SG, Kim HJ, Lee SY, Cha MJ, Hwang HH. A study of anger, alexithymia, and depression in the functional dyspepsia. J Korean Acad Fam Med 2002;23:881-889.
  8. Jang SH, Ryu HS, Choi SC, Lee HJ, Lee SY. A study of ef- fects of psychosocial factors and quality of life on functional dyspepsia in firefighters. Korean J Psychosom Med 2016;24: 66-73.
  9. Yang XJ, Jiang HM, Hou XH, Song J. Anxiety and depres- sion in patients with gastroesophageal refux disease and their effect on quality of life. World J Gastroenterol 2015;21:4302- 4309. https://doi.org/10.3748/wjg.v21.i14.4302
  10. Oreski I, Jakovljevic M, Aukst-Margetic B, Crncevic Orlic Z, Vuksan-Cusa B. Comorbidity and multimorbidity in patients with schizophrenia and bipolar disorder: similarities and dif- ferencies. Psychiatr Danub 2012;24:80-85.
  11. Molloy CA, Manning-Courtney P. Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders. Autism 2003;7:165-171. https://doi.org/10.1177/1362361303007002004
  12. Noyes R, Cook B, Garvey M, Summers R. Reduction of gastrointestinal symptoms following treatment for panic disorder. Psychosomatics 1990;31:75-79. https://doi.org/10.1016/S0033-3182(90)72220-7
  13. Lydiard R. Increased prevalence of functional gastrointestinal disorders in panic disorder: clinical and theoretical implications. CNS Spectr 2005;10:899-908. https://doi.org/10.1017/S1092852900019878
  14. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R. The montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastrol 2006;101:1900-1920. https://doi.org/10.1111/j.1572-0241.2006.00630.x
  15. Upadhyaya AK, Stanley I. Hospital anxiety depression scale. Br J Gen Pract 1993;43:349-373.
  16. Oh SM, Min KJ, Park DB. A study on the standardization of the hospital anxiety and depression scale for Koreans. J Korean Neuropsychiatr Assoc 1999;38:289-296.
  17. Forgays DG, Forgays DK, Spielberger CD. Factor structure of the state-trait anger expression inventory. J Pers Assess 1997; 69:497-507. https://doi.org/10.1207/s15327752jpa6903_5
  18. Hahn DW. Korean adaptation of the state-trait anger expression inventory (STAXI-K): The case of college students. Korean J Health Psychol 1998;3:18-32.
  19. Yu JH, Park JS, Park DH, Yu SH, Ha JH. Validation of the Korean childhood trauma questionnaire: the practical use in counselling and therapeutic intervention. Korean J Health Psychol 2009;4:563-578.
  20. Kim DH, Park SC, Yang HJ, Oh DH. Reliability and validity of the korean version of the childhood trauma questionnaire-short form for psychiatric outpatients. Psychiatry Investig 2011;8:305-311. https://doi.org/10.4306/pi.2011.8.4.305
  21. Kroenke K, Spitzer RL, Williams JB, Lowe B. The patient health questionnaire somatic, anxiety, and depressive symptom scales: a systematic review. Gen Hosp Psychiatry 2010;32:345-359. https://doi.org/10.1016/j.genhosppsych.2010.03.006
  22. Han C, Pae CU, Patkar AA, Masand PS, Kim KW, Joe SH, Jung IK. Psychometric properties of the Patient Health Questionnaire-15 (PHQ-15) for measuring the somatic symptoms of psychiatric outpatients. Psychosomatics 2009;50:580-585.
  23. Koloski NA, Talley NJ, Boyce PM. Epidemiology and health care seeking in the functional GI disorders: a population-based study. Am J Gastroenterol 2002;97:2290-2299. https://doi.org/10.1111/j.1572-0241.2002.05783.x
  24. Kim PH, Kim HS. Relationships between perceived stress, mental health, and social support in community residents. J Korean Public Health Nurs 2010;24:197-210.
  25. Lydiard RB, Fossey MD, Marsh W, Ballenger JC. Prevalence of psychiatric disorders in patients with irritable bowel syndrome. Psychosomatics 1993;34:229-234. https://doi.org/10.1016/S0033-3182(93)71884-8
  26. Modabbernia, MJ, Mansour-Ghanaei F, Imani A, Mirsafa-Moghaddam SA, Sedigh-Rahimabadi M, Yousefi-Mashhour M, Bidel S. Anxiety-depressive disorders among irritable bowel syndrome patients in Guilan, Iran. BMC Res Notes 2012;5:112-118. https://doi.org/10.1186/1756-0500-5-112
  27. Cardno AG, Gottesman II. Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. Am J Med Genet A 2000;97:12-17. https://doi.org/10.1002/(SICI)1096-8628(200021)97:1<12::AID-AJMG3>3.0.CO;2-U
  28. Lee SP, Sung IK, Kim JH, Lee SY, Park HS, Shim CS. The effect of emotional stress and depression on the prevalence of digestive diseases. J Neurogastroenterol Motil 2015;21:273- 282. https://doi.org/10.5056/jnm14116
  29. Pinto-Sanchez MI, Ford AC, Avila CA, Verdu EF, Collins SM, Morgan D. Anxiety and depression increase in a step- wise manner in parallel with multiple FGID and symptom se- verity and frequency. Am J Gastroenterol 2015;110:1038-1048. https://doi.org/10.1038/ajg.2015.128
  30. Foster JA, Neufeld KAM. Gut-brain axis: how the microbi- ome infuences anxiety and depression. Trends Neurosci 2013; 36:305-312. https://doi.org/10.1016/j.tins.2013.01.005
  31. Vanuytsel T, Van Wanrooy S, Vanheel H, Vanormelingen C, Verschueren S, Houben E, Van Oudenhove L. Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut 2014;63:1293-1299. https://doi.org/10.1136/gutjnl-2013-305690
  32. Larauche M. Novel insights in the role of peripheral corticotropin-releasing factor and mast cells in stress-induced visceral hypersensitivity. J Neurogastroenterol Motil 2012;2:201-205.
  33. Levy RL, Olden KW, Naliboff BD, Bradley LA, Francisconi C, Drossman DA, Creed F. Psychosocial aspects of the functional gastrointestinal disorders. Gastroenterol 2006;130: 1447-1458. https://doi.org/10.1053/j.gastro.2005.11.057
  34. Drossman DA, Leserman J, Nachman G, Li Z, Gluck H, Toomey TC, Mitchell CM. Sexual and physical abuse in women with functional or organic gastrointestinal disorders. Ann Intern Med 1990;113:828-833. https://doi.org/10.7326/0003-4819-113-11-828
  35. Bennett EJ, Piesse C, Palmer K, Badcock CA, Tennant CC, Kellow JE. Functional gastrointestinal disorders: psychological, social, and somatic features. Gut 1998;42:414-420. https://doi.org/10.1136/gut.42.3.414
  36. Bennett EJ, Evans P, Scott AM, Badcock CA, Shuter B, Hoschl R, Kellow JE. Psychological and sex features of delayed gut transit in functional gastrointestinal disorders. Gut 2000; 46:83-87. https://doi.org/10.1136/gut.46.1.83
  37. Spielberger CD, Krasner SS, Solomon EP. The experience, expression, and control of anger: Individual differences, stress, and health psychology. New York: N.Y. Springer;1988. p.89-108.