Korean Journal of Psychosomatic Medicine (정신신체의학)

Korean Psychosomatic Society (한국정신신체의학회)
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Factors Influencing on the Cognitive Function in Type 2 Diabetics

2형 당뇨병 환자의 인지 기능에 영향 미치는 인자

  • Goh, Dong Hwan (Department of Psychiatry, Kosin University College of Medicine) ;
  • Cheon, Jin Sook (Department of Psychiatry, Kosin University College of Medicine) ;
  • Choi, Young Sik (Department of Internal Medicine, Kosin University College of Medicine) ;
  • Kim, Ho Chan (Department of Psychiatry, Kosin University College of Medicine) ;
  • Oh, Byoung Hoon (Department of Psychiatry, Yonsei University College of Medicine)
  • 고동환 (고신대학교 의과대학 정신건강의학교실) ;
  • 전진숙 (고신대학교 의과대학 정신건강의학교실) ;
  • 최영식 (고신대학교 의과대학 내과학교실) ;
  • 김호찬 (고신대학교 의과대학 정신건강의학교실) ;
  • 오병훈 (연세대학교 의과대학 정신건강의학교실)
  • Received : 2018.04.25
  • Accepted : 2018.06.25
  • Published : 2018.06.30
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Abstract

Objectives : The aims of this study were to know the frequency and the nature of cognitive dysfunction in type 2 diabetics, and to reveal influencing variables on it. Methods : From eighty type 2 diabetics (42 males and 38 females), demographic and clinical data were obtained by structured interviews. Cognitive functions were measured using the MMSE-K (Korean Version of the Mini-Mental State Examination) and the Korean Version of the Montreal Cognitive Assessment (MoCA-K) tests. Severity of depression was evaluated by the Korean Version of the Hamilton Depression Rating Scale (K-HDRS). Results : 1) Among eighty type 2 diabetics, 13.75% were below 24 on the MMSE-K, while 38.8% were below 22 on the MoCA-K. 2) The total scores and subtest scores of the MoCA-K including visuospatial/ executive, attention, language, delayed recall and orientation were significantly lower in type 2 diabetics with cognitive dysfunction (N=31) than those without cognitive dysfunction (N=49) (p<0.001, respectively). 3) There were significant difference between type 2 diabetics with and those without cognitive dysfunction in age, education, economic status, body mass index, duration of diabetes, total scores of the K-HDRS, the MMSE-K and the MoCA-K (p<0.05, respectively). 4) The total scores of the MoCA-K had significant correlation with age, education, body mass index, family history of diabetes, duration of diabetes, total scores of the K-HDRS (p<0.05, respectively). 5) The risks of cognitive dysfunction in type 2 diabetics were significantly influenced by sex, education, fasting plasma glucose and depression. Conclusions : The cognitive dysfunction in type 2 diabetics seemed to be related to multiple factors. Therefore, more comprehensive biopsychosocial approaches needed for diagnosis and management of type 2 diabetes.

연구목적 본 연구의 목적은 2형 당뇨병 환자에서 인지 장애의 빈도와 특성 및 이에 연관되는 변인과 위험 인자를 알아보기 위함이다. 방 법 2형 당뇨병 환자 80명(남성 42명, 여성 38명)을 대상으로 구조적 면담을 통해서 인구학적 및 임상적 정보를 얻었다. 한국판 간이 정신상태 평가(K-MMSE)와 한국판 몬트리올 인지평가(MoCA-K)를 사용해서 인지기능을 평가하였고, 한국판 Hamilton 우울증 평가 척도(K-HDRS)를 사용해서 우울증을 평가하였다. 결 과 1) MMSE-K 총점 24점 이하는 13.75%, MoCA-K 총점 22점 이하는 38.8%였다. 2) 2형 당뇨병 환자 중에서 인지 장애가 있는 군(N=31명)은 인지 장애가 없는 군(N=49명) 보다 MoCA-K 총점, 시공간/실행력, 주의력, 언어, 지연 회상력, 지남력 소검사 점수가 유의하게 낮았다(p<0.001). 3) 인지 장애가 있는 군과 인지 장애가 없는 군 간에는 연령, 교육 수준, 경제 상태, 체질량 지수, 당뇨병 이병 기간, K-HDRS 총점, MMSE-K 총점 및 MoCA-K 총점에서 유의한 차이가 있었다(p<0.05). 4) MoCA-K 총점은 연령, 교육 수준, 체질량 지수, 당뇨병의 가족력, 당뇨병의 이병 기간, K-HDRS 총점과 유의한 상관관계가 있었다(p<0.05). 5) 2형 당뇨병 환자에서 남성, 낮은 교육 수준, 높은 공복 혈당치, 우울증의 심한 정도는 유의하게 인지 장애의 위험을 증가시킨다. 결 론 2형 당뇨병 환자의 인지 장애는 복합적인 여러 요인이 관계되는 것으로 생각된다. 따라서 이들의 진단과 치료에는 생물 심리 사회학적인 관점이 망라된 좀 더 포괄적인 접근이 요청된다.

Keywords

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