Genomics & Informatics

Korea Genome Organization (한국유전체학회)
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HisCoM-GGI: Software for Hierarchical Structural Component Analysis of Gene-Gene Interactions

  • Choi, Sungkyoung (Department of Pharmacology, Yonsei University College of Medicine) ;
  • Lee, Sungyoung (Center for Precision Medicine, Seoul National University Hospital) ;
  • Park, Taesung (Department of Statistics, Seoul National University)
  • Received : 2018.12.11
  • Accepted : 2018.12.18
  • Published : 2018.12.31
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Abstract

Gene-gene interaction (GGI) analysis is known to play an important role in explaining missing heritability. Many previous studies have already proposed software to analyze GGI, but most methods focus on a binary phenotype in a case-control design. In this study, we developed "Hierarchical structural CoMponent analysis of Gene-Gene Interactions" (HisCoM-GGI) software for GGI analysis with a continuous phenotype. The HisCoM-GGI method considers hierarchical structural relationships between genes and single nucleotide polymorphisms (SNPs), enabling both gene-level and SNP-level interaction analysis in a single model. Furthermore, this software accepts various types of genomic data and supports data management and multithreading to improve the efficiency of genome-wide association study data analysis. We expect that HisCoM-GGI software will provide advanced accessibility to researchers in genetic interaction studies and a more effective way to understand biological mechanisms of complex diseases.

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References

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