The Korean journal of helicobacter and upper gastrointestinal research (대한상부위장관⦁헬리코박터학회지)

Korean College of Helicobacter and upper Gastrointestinal Reseaarch (대한상부위장관ㆍ헬리코박터학회)
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Randomized, Double-blind, Placebo-controlled Clinical Trial for the Evaluation of the Efficacy and Safety of Artemisia and Green Tea Extract SD1003F in Volunteers with Helicobacter pylori-associated Gastric Discomfort

인진쑥과 녹차 추출물 복합물인 SD1003F의 Helicobacter pylori 연관 기능성 위장장애 지원자에 대한 유효성 및 안전성 평가를 위한 무작위 배정, 이중 맹검, 위약대조 임상시험

  • Kwon, Sang Oh (S&D Food Research Center) ;
  • Kwak, Dong Yun (S&D Food Research Center) ;
  • Hong, Sung Pyo (Digestive Disease Center, CHA Bundang Medical Center, CHA University) ;
  • Kim, Won Hee (Digestive Disease Center, CHA Bundang Medical Center, CHA University) ;
  • Park, Jong Min (CHA Cancer Prevention Research Center) ;
  • Han, Young Min (CHA Cancer Prevention Research Center) ;
  • Kang, You (CHA Cancer Prevention Research Center) ;
  • Kang, Eun A (CHA Cancer Prevention Research Center) ;
  • Jo, Seohyun (Digestive Disease Center, CHA Bundang Medical Center, CHA University) ;
  • Hahm, Ki Baik (Digestive Disease Center, CHA Bundang Medical Center, CHA University)
  • 권상오 (S&D 기업부설연구소) ;
  • 곽동윤 (S&D 기업부설연구소) ;
  • 홍성표 (CHA 의과학대학교 분당차병원 소화기센터) ;
  • 김원희 (CHA 의과학대학교 분당차병원 소화기센터) ;
  • 박종민 (CHA Bio Complex 차 암예방 연구센터) ;
  • 한영민 (CHA Bio Complex 차 암예방 연구센터) ;
  • 강유 (CHA Bio Complex 차 암예방 연구센터) ;
  • 강은아 (CHA Bio Complex 차 암예방 연구센터) ;
  • 조서현 (CHA 의과학대학교 분당차병원 소화기센터) ;
  • 함기백 (CHA 의과학대학교 분당차병원 소화기센터)
  • Received : 2017.08.29
  • Accepted : 2017.11.09
  • Published : 2018.03.10
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Abstract

Background/Aims: A previous study showed that dietary intervention with Artemisia and green tea extracts, i.e., SD1003F, relieved Helicobacter pylori-associated chronic atrophic gastritis in a mouse model. We continue the research through the current randomized double-blind clinical trial to evaluate the efficacy and safety of the intervention for H. pylori-associated gastric discomfort. Materials and Methods: Forty-nine volunteers who tested positive for H. pylori infection received either placebo or SD1003F for 10 weeks and their functional dyspepsia-related quality of life (QOL) was evaluated. H. pylori infection using a urea breath test (UBT), measurement of pepsinogen level using GastroPanel. Adverse effects with biochemical changes were also evaluated. Results: SD1003F administration significantly improved health related-QOL, including dietary intake, emotional stability, life pattern, and social factors relevant to gastric discomfort, in comparison to the control (P<0.05). The mean UBT measurement significantly decreased in the SD1003F group (P<0.05). In 2 of the 24 volunteers, SD1003F alone eradicated H. pylori infection, with significant improvements in endoscopic findings. GastroPanel analysis revealed significant improvements that reflect rejuvenation of gastric atrophy in the SD1003F group. No significant side effect was observed in any participant. Conclusions: SD1003F (Artemisia and green tea extract), is a potential phytochemical to improve H. pylori-associated gastric discomfort.

Keywords

References

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