DOI QR코드

DOI QR Code

Prevalence of Comorbidities among Patients with Diabetes

당뇨병에서의 동반질환 유병률 및 조합유병률

  • Kim, Suyoung (Health Promotion Research Institute, Korea Association of Health Promotion) ;
  • Nah, Eun-Hee (Health Promotion Research Institute, Korea Association of Health Promotion) ;
  • Cho, Seon (Health Promotion Research Institute, Korea Association of Health Promotion)
  • 김수영 (한국건강관리협회 건강증진연구소) ;
  • 나은희 (한국건강관리협회 건강증진연구소) ;
  • 조선 (한국건강관리협회 건강증진연구소)
  • Received : 2018.07.31
  • Accepted : 2018.08.28
  • Published : 2018.08.31

Abstract

Objectives: The patients with diabetes often have one or more comorbidities. To make a clinical decision for the choice of medicine as well as to manage chronic diseases, understanding individual or combination of comorbidities is necessary. This study aimed to investigate the prevalence of comorbidities in diabetes patients. Methods: The comorbidities was defined to include obesity, hypertension (HTN), anemia, dyslipidemia, liver disease or kidney disease. This study included 212,608 adults with diabetes defined as fasting blood glucose ${\geq}126mg/dL$, hemoglobin A1c ${\geq}6.5%$ or individuals who have taken anti-diabetes medication, from 16 health promotion centers in Korea from January 2014 to Decemver 2015. Data was summarized by descriptive analyses on the combinations of comorbidity of condition by subgroups of age and sex. Results: Of the Korean adults with diabetes, 88% had one or more comorbidity. The highest prevalence of individual comorbidity was 50.5% in hypertension, followed 50% in obesity, 47.1% in dyslipidemia, 25.7% in liver disease and 14.8% in kidney disease. Comorbid conditions such as HTN, anemia and kidney disease tended to increase in older age group. Most of individual comorbidities were similaror higherin men except for hypertensionand anemia. In addition, 67.3% of the participants had at least two comorbidities with diabetes. The comorbidity burden of the diabetes patients with obesity and other disease was high; 28.8% in obesity and HTN, 26.0% in obesity and dyslipidemia. Conclusions: There is a high prevalence of comorbidity of two or more diseases including obesity or HTN among diabetes patients. To effectively treat and manage diabetes, there should be careful consideration about the presence of multi-morbidity and approach to health promotion including chronic disease management.

Keywords

References

  1. WHO. WHO Diabetes fact sheets. Available at http://www.who.int/news-room/fact-sheets/detail/diabetes [accessed on July 12, 2018].
  2. Korean Diabetes Association. Diabetes fact sheet in Korea 2018. Seoul: Korean Diabetes Association; 2018 (Korean).
  3. The Organisation for Economic Co-operation and Developmen. OECD stat, health status. Available at https://stats.oecd.org/viewhtml.aspx?datasetcode=HEALTH_STAT&lang=en# [accessed on July 12, 2018].
  4. Korean Diabetes Association. Korean diabetes fact sheet 2015. Seoul: Korean Diabetes Association, National health insurance service; 2015(Korean).
  5. Ha KH, Kim DJ. Trends in the diabetes epidemic in Korea. Endocrinol Metab 2015;30:142-146. https://doi.org/10.3803/EnM.2015.30.2.142
  6. Korean Diabetes Association. Diabetes fact sheet in Korea 2012. Seoul: Korean Diabetes Association, Korea Centers for Disease Control and Prevention; 2012 (Korean).
  7. Gu K, Cowie CC, Harris MI. Diabetes and decline in heart disease mortality in US adults. JAMA J Am Med Assoc 1999; 281:1291-1297. https://doi.org/10.1001/jama.281.14.1291
  8. Oldridge NB, Stump TE, Nothwehr FK, Clark DO. Prevalence and outcomes of comorbid metabolic and cardiovascular conditions in middle- and older-age adults. J Clin Epidemiol 2001;54:928-934. https://doi.org/10.1016/S0895-4356(01)00350-X
  9. Colosia AD, Palencia R, Khan S. Prevalence of hypertension and obesity in patients with type 2 diabetes mellitus in observational studies: a systematic literature review. Diabetes Metab Syndr Obes 2013;6:327-338.
  10. Bajaj S, Makkar BM, Abichandani VK, Talwalkar PG, Saboo B, Srikanta SS, et al. Management of anemia in patients with diabetic kidney disease: a consensus statement. Indian J Endocrinol Metab 2016;20(2):268-281. https://doi.org/10.4103/2230-8210.176348
  11. Meduru P, Helmer D, Rajan M, Tseng CL, Pogach L, Sambamoorthi U. Chronic illness with complexity: implications for performance measurement of optimal glycemic control. J Gen Intern Med 2007;22(Suppl 3):408-418. https://doi.org/10.1007/s11606-007-0310-5
  12. World Health Organization. The Asia-Pacific perspective: redefining obesity and its treatment. Regional office for the Western Pacific; 2000, p. 17-20.
  13. Ministry of Health and Welfare. Framework act on national health examination 2015. Sejong: Ministry of Health and Welfare; 2015 (Korean).
  14. Teljeur C, Smith SM, Paul G, Kelly A, O'Dowd T. Multimorbidity in a cohort of patients with type 2 diabetes. Eur J Gen Pract 2013:19(1);17-22. DOI: 10.3109/13814788.2012.714768
  15. Luijks H, Schermer T, Bor H, Weel C, Lagro-Janssen T, Biermans M, et al. Prevalence and incidence density rates of chronic comorbidity in type 2 diabetes patients: an exploratory cohort study. BMC Med 2012;10(128):1-10. https://doi.org/10.1186/1741-7015-10-1
  16. Alonso-Moran E, Orueta JF, Esteban JIF, ArteagoitiaAxpe JM, Marques Gonzalez ML, Polanco NT, et al. The prevalence of diabetes-related complications and multimorbidity in the population with type 2 diabetes mellitus in the Basque Country. BMC Public Health 2014;14(1059):1-9. https://doi.org/10.1186/1471-2458-14-1
  17. Gomis R, Artola S, Conthe P, Vidal J, Casamor R, Font B, et al. Prevalence of type 2 diabetes mellitus in overweight or obese patients outpatients in Spain. OBEDIA Study. Med Clin (Barc) 2014;142:485-492. https://doi.org/10.1016/j.medcli.2013.03.013
  18. Harjutsalo V, Groop PH. Epidemiology and risk factors for diabetic kidney disease. Adv Chronic Kidney Dis 2014;21:260-266. https://doi.org/10.1053/j.ackd.2014.03.009
  19. Kabakov E, Norymberg C, Osher E, Koffler M, Tordjman K, Greenman Y, et al. Prevalence of hypertension in type 2 diabetes mellitus: impact of the tightening definition of high blood pressure and association with confounding risk factors. J Cardiometabolic Syndr 2006;1(2):95-101. https://doi.org/10.1111/j.1559-4564.2006.05513.x
  20. Bralic Lang V, Bergman Markovic B. Prevalence of comorbidity in primary care patients with type 2 diabetes and its association with elevated HbA1c: a cross-sectional study in Croatia. Scand J Prim Health Care 2016;34(1):66-72. DOI: 10.3109/02813432.2015.1132886
  21. Wexler DJ, Grant RW, Meigs JB, Nathan DM, Cagliero E. Sex disparities in treatment of cardiac risk factors in patients with type 2 diabetes. Diabetes care 2005;28(3):514-520. https://doi.org/10.2337/diacare.28.3.514
  22. Davis JW, Chung R, Juarez DT. Prevalence of comorbid conditions with aging among patients with diabetes and cardiovascular disease. Hawaii Med J 2011;70(10):209-213.
  23. Ferrannini E, Cushman WC. Diabetes and hypertension: the bad companions. Lancet 2012;380:601-610. https://doi.org/10.1016/S0140-6736(12)60987-8
  24. Lin P, Kent DM, Winn AN, Cohen JT, Neumann PJ. Multiple chronic conditions in type 2 diabetes mellitus: prevalence and consequences. Am J Manag Care 2015;21(1):e23-e34.
  25. Chen H, Zhang Y, Wu D, Gong C, Pan Q, Dong X, et al. Comorbidity in adult patients hospitalized with type 2 diabetes in Northeast China: an analysis of hospital discharge data from 2002 to 2013. BioMed Res Int 2016; 2016(10/25/2016):1-9. DOI: 10.1155/2016/1671965
  26. Shibata M, Kihara Y, Taguchi M, Tashiro M, Otsuki M. Nonalcoholic fatty liver disease is arisk factor for type 2 diabetes in middle-aged Japanese men. Diabetes Care 2007;30:2940-2944. https://doi.org/10.2337/dc07-0792

Cited by

  1. Intraocular Pressure: Intravitreal Preservative-free Triamcinolone Injection in Diabetic Macular Edema and Branch Retinal Vein Occlusion vol.61, pp.2, 2018, https://doi.org/10.3341/jkos.2020.61.2.167
  2. 당뇨병 환자의 당뇨성 안질환 및 신장질환 합병증 검사 수검 여부에 영향을 주는 요인 vol.21, pp.4, 2018, https://doi.org/10.5762/kais.2020.21.4.226
  3. Challenges in the Management of Diabetes in Primary Care vol.21, pp.3, 2020, https://doi.org/10.4093/jkd.2020.21.3.161
  4. 제2형 당뇨병 환자에게 한방의료보험용 혼합엑기스산제와 경구혈당강하제 병용요법이 혈당 변화에 미치는 영향 vol.41, pp.6, 2018, https://doi.org/10.22246/jikm.2020.41.6.1231
  5. Factors Associated with Poor Glycemic Control Amongst Rural Residents with Diabetes in Korea vol.9, pp.4, 2018, https://doi.org/10.3390/healthcare9040391
  6. Efficacy and Safety of Aronia, Red Ginseng, Shiitake Mushroom, and Nattokinase Mixture on Insulin Resistance in Prediabetic Adults: A Randomized, Double-Blinded, Placebo-Controlled Trial vol.10, pp.7, 2018, https://doi.org/10.3390/foods10071558