The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Review of Clinical Research for Herbal Medicine Treatment on Rhinosinusitis

비부비동염의 보완대체의학 약물치료에 대한 최신 임상 연구 동향 -RCT 연구를 중심으로 -

  • Jang, Eun Ha (Department of Pediatrics, Dongguk University Bundang Oriental Hospital) ;
  • Min, Sang Yeon (Department of Pediatrics, Dongguk University Ilsan Oriental Hospital) ;
  • Kim, Jang Hyun (Department of Pediatrics, Dongguk University Bundang Oriental Hospital)
  • 장은하 (동국대학교 분당한방병원 한방소아과) ;
  • 민상연 (동국대학교 일산한방병원 한방소아과) ;
  • 김장현 (동국대학교 분당한방병원 한방소아과)
  • Received : 2018.07.25
  • Accepted : 2018.08.14
  • Published : 2018.08.31
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Abstract

Objectives The purpose of this study is to analyze clinical studies on effectiveness of herbal medicine in rhinosinusitis. Methods We searched the randomized controlled trials (RCTs) with herbal medicine treatment on rhinosinusitis from the Pubmed in recent 10 years (from 2008 to 2018). Results 11 RCTs were reviewed. In 10 out of 11 studies showed that the herbal medicine may be effective in the treatment of chronic rhinosinusitis without nasal polyp and uncomplicated acute rhinosinusitis. However, inclusion and exclusion criteria, and outcome measures were varied among different studies. No serious adverse reactions were reported from the herbal medicine treatment. Conclusions The results of these trials showed that herbal medicine may be effective in the treatment of rhinosinusitis. Well-designed RCTs for domestic herbal medicine treatment on rhinosinusitis are needed to prove its efficacy clearly.

Keywords

References

  1. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaert P, Georgalas C, Goossens H, Harvey R, Hellings P, Hopkins C, Jones N, Joos G, Kalogjera L, Kern B, Kowalski M, Price D, Riechelmann H, Schlosser R, Senior B, Thomas M, Toskala E, Voegels R, Wang DW, Wormald PJ. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology. 2012;50(1):1-12. https://doi.org/10.4193/Rhino50E2
  2. Lee HJ. Diagnosis and treatment of acute rhinosinusitis in children. J Korean Med Assoc. 2018;61(2):125-9. https://doi.org/10.5124/jkma.2018.61.2.125
  3. Schultz MJ. Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and cystic fibrosis. J Antimicrob Chemother. 2004;54(1):21-8. https://doi.org/10.1093/jac/dkh309
  4. Wallwork B, Coman W, Mackay-Sim A, Greiff L, Cervin A. A double-blind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis. Laryngoscope. 2006;116(2):189-93. https://doi.org/10.1097/01.mlg.0000191560.53555.08
  5. Pearlman AN, Conley DB. Review of current guidelines related to the diagnosis and treatment of rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2008;16(3):226-30. https://doi.org/10.1097/MOO.0b013e3282fdcc9a
  6. Jang YW, Kim JY, Lee SH, Lim SH. A literature study of Korean medicine for sinusitis. J Korean Med Ophthalmol Otolaryngol Dermatol. 2017;30(3):134-54. https://doi.org/10.6114/JKOOD.2017.30.3.134
  7. Jiang RS, Wu SH, Tsai CC, Li YH, Liang KL. Efficacy of Chinese herbal medicine compared with a macrolide in the treatment of chronic rhinosinusitis without nasal polyps. Am J Rhinol Allergy. 2012;26(4):293-7. https://doi.org/10.2500/ajra.2012.26.3778
  8. Liang KL, Su YC, Tsai CC, Lin JS, Jiang RS, Su MS. Postoperative care with Chinese herbal medicine or amoxicillin after functional endoscopic sinus surgery: a randomized, double-blind, placebo-controlled study. Am J Rhinol Allergy. 2011;25(3):170-5. https://doi.org/10.2500/ajra.2011.25.3610
  9. Maragalawaththa MG, Ediriweera ER, Chandimarathne PB. A clinical trial of Sri Lankan traditional decoction of Pitawakka Navaya in treatment of Kaphaja Shirsha Shoola (chronic sinusitis). Ayu. 2010;31(2):193-6. https://doi.org/10.4103/0974-8520.72390
  10. Ediriweera ER, Rathnayaka RL, Premakeerthi WM, Weerasinghe KD. Efficacy of Sri Lankan traditional decoction of Katuwelbatu Deduru Katukadi in treatment of Kaphaja Shira Shula (chronic sinusitis). Ayu. 2010; 31(1):58-61. https://doi.org/10.4103/0974-8520.68208
  11. Tesche S, Metternich F, Sonnemann U, Engelke JC, Dethlefsen U. The value of herbal medicines in the treatment of acute non-purulent rhinosinusitis. Results of a double-blind, randomised, controlled trial. Eur Arch Otorhinolaryngol. 2008;265(11):1355-9. https://doi.org/10.1007/s00405-008-0683-z
  12. Jund R, Mondigler M, Steindl H, Stammer H, Stierna P, Bachert C. Clinical efficacy of a dry extract of five herbal drugs in acute viral rhinosinusitis. Rhinology. 2012;50(4):417-26. https://doi.org/10.4193/Rhin12.015
  13. Jund R, Mondigler M, Steindl H, Stammer H, Stierna P, Bachert C. Clinical efficacy of a herbal drug combination in acute viral rhinosinusitis. MMW Fortschr Med. 2015;157(157Suppl4):6-11.
  14. Passali D, Loglisci M, Passali GC, Cassano P, Rodriguez HA, Bellussi LM. A prospective open-label study to assess the efficacy and safety of a herbal medicinal product (Sinupret) in patients with acute rhinosinusitis. ORL J Otorhinolaryngol Relat Spec. 2015;77(1):27-32. https://doi.org/10.1159/000370123
  15. Jund R, Mondigler M, Stammer H, Stierna P, Bachert C. Herbal drug BNO 1016 is safe and effective in the treatment of acute viral rhinosinusitis. Acta Otolaryngol. 2015;135(1):42-50. https://doi.org/10.3109/00016489.2014.952047
  16. Palm J, Steiner I, Abramov-Sommariva D, Ammendola A, Mitzenheim S, Steindl H, Wonnemann M, Bachert C. Assessment of efficacy and safety of the herbal medicinal product BNO 1016 in chronic rhinosinusitis. Rhinology. 2017;55(2):142-51. https://doi.org/10.4193/Rhin16.103
  17. Vazifehkah S, Shams-Ardekani MR, Kamalinejad M, Saderhossein SM, Hosseini H, Shams SM, Abbassi S, Eghtesad S, Saedi B. Evaluation of a novel natural drop for treatment of chronic rhinosinusitis without nasal polyps: a single blind randomized trial. Int Forum Allergy Rhinol. 2016;6(9):943-9. https://doi.org/10.1002/alr.21785
  18. Cho HJ, Kim HY. Pediatric chronic rhinosinusitis. Korean J Otorhinolaryngol Head Neck Surg. 2015;58 (10):667-75. https://doi.org/10.3342/kjorl-hns.2015.58.10.667
  19. Korea Centers for Disease Control and Prevention. Guidelines for the antibiotic use in children with acute upper respiratory tract infections. Cheongju: Korea Centers for Disease Control and Prevention. 2016.
  20. Chow AW, Benninger MS, Brook I, Brozek JL, Goldstein EJ, Hicks LA, Pankey GA, Seleznick M, Volturo G, Wald ER, File TM. IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis. 2012;54(8):e72-112. https://doi.org/10.1093/cid/cis370
  21. Hong SN, Kim DW. Medical treatment according to phenotypes of chronic rhinosinusitis. Allergy Asthma Respir Dis. 2015;3(3):167-72. https://doi.org/10.4168/aard.2015.3.3.167
  22. Pynnonen MA, Mukerji SS, Kim HM, Adams ME, Terrell JE. Nasal saline for chronic sinonasal symptoms: a randomized controlled trial. Arch Otolaryngol Head Neck Surg. 2007;133(11):1115-20. https://doi.org/10.1001/archotol.133.11.1115
  23. Browne JP, Hopkins C, Slack R, Cano SJ. The Sino-Nasal Outcome Test (SNOT): can we make it more clinically meaningful?. Otolaryngol Head Neck Surg. 2007;136(5): 736-41. https://doi.org/10.1016/j.otohns.2007.01.024
  24. Hong JH, Kim KH, An JH, Jung HA. A case of sinusitis patient improved by Kami-Hyunggyeyungyotang. J Korean Med Ophthalmol Otolaryngol Dermatol. 2015; 28(2):66-74. https://doi.org/10.6114/jkood.2015.28.2.066
  25. Jang JH, Park JH. Two cases report of oriental medical therapy for sinusitis in the overweight children. J Korean Med Ophthalmol Otolaryngol Dermatol. 2016;29(2): 149-60. https://doi.org/10.6114/jkood.2016.29.2.149
  26. Nam HJ, Kim YB. A case of headache induced by paranasal sinusitis in child. J Korean Med Ophthalmol Otolaryngol Dermatol. 2003;16(1):159-67.
  27. Lee HM, Park SH. A case of chronic sinusitis patient improved by Yangdokbackho-tang. J Sasang Constitut Med. 2007;19(3):283-92.
  28. Lee KJ, Yoon YH, Choi IH, Ko SG. 5 cases of rhinosinusitis diagnosed and evaluated by OMU CT. J Korean Med Ophthalmol Otolaryngol Dermatol. 2014;27(3):133-44. https://doi.org/10.6114/jkood.2014.27.3.133
  29. Kim SB, Kim JS, Kim GJ. The clinical observation on cases of chronic paranasal sinus. J Korean Med Ophthalmol Otolaryngol Dermatol. 2001;14(2):1-8.