Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Impact of Model-Based Iterative Reconstruction on the Correlation between Computed Tomography Quantification of a Low Lung Attenuation Area and Airway Measurements and Pulmonary Function Test Results in Normal Subjects

  • Kim, Da Jung (Department of Radiology, Korea University College of Medicine, Korea University Ansan Hospital) ;
  • Kim, Cherry (Department of Radiology, Korea University College of Medicine, Korea University Ansan Hospital) ;
  • Shin, Chol (Department of Pulmonology, Korea University College of Medicine, Korea University Ansan Hospital) ;
  • Lee, Seung Ku (Institute for Human Genomic Study, Korea University College of Medicine, Korea University Ansan Hospital) ;
  • Ko, Chang Sub (Department of Radiology, Korea University College of Medicine, Korea University Ansan Hospital) ;
  • Lee, Ki Yeol (Department of Radiology, Korea University College of Medicine, Korea University Ansan Hospital)
  • Received : 2018.03.20
  • Accepted : 2018.06.28
  • Published : 2018.12.01
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Abstract

Objective: To compare correlations between pulmonary function test (PFT) results and different reconstruction algorithms and to suggest the optimal reconstruction protocol for computed tomography (CT) quantification of low lung attenuation areas and airways in healthy individuals. Materials and Methods: A total of 259 subjects with normal PFT and chest CT results were included. CT scans were reconstructed using filtered back projection, hybrid-iterative reconstruction, and model-based IR (MIR). For quantitative analysis, the emphysema index (EI) and wall area percentage (WA%) were determined. Subgroup analysis according to smoking history was also performed. Results: The EIs of all the reconstruction algorithms correlated significantly with the forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) (all p < 0.001). The EI of MIR showed the strongest correlation with FEV1/FVC (r = -0.437). WA% showed a significant correlation with FEV1 in all the reconstruction algorithms (all p < 0.05) correlated significantly with FEV1/FVC for MIR only (p < 0.001). The WA% of MIR showed the strongest correlations with FEV1 (r = -0.205) and FEV1/FVC (r = -0.250). In subgroup analysis, the EI of MIR had the strongest correlation with PFT in both eversmoker and never-smoker subgroups, although there was no significant difference in the EI between the reconstruction algorithms. WA% of MIR showed a significantly thinner airway thickness than the other algorithms ($49.7{\pm}7.6$ in ever-smokers and $49.5{\pm}7.5$ in never-smokers, all p < 0.001), and also showed the strongest correlation with PFT in both ever-smoker and never-smoker subgroups. Conclusion: CT quantification of low lung attenuation areas and airways by means of MIR showed the strongest correlation with PFT results among the algorithms used, in normal subjects.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF), Korea Centers for Disease Control and Prevention, Reyon Pharmaceutical, Philips Company

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