Journal of Sasang Constitutional Medicine (사상체질의학회지)

The Society Of Sasang Constitutional Medicine (사상체질의학회)
권호 표지
DOI QR코드

DOI QR Code

Review of experimental and clinical studies on Cheongsimyeonja-tang in Korea

청심연자탕의 연구 동향

  • An, Da-Young (Depart. of Sasang Constitutional Medicine, College of Korean Medicine, Sangji University) ;
  • Han, Su-Zy (Depart. of Sasang Constitutional Medicine, College of Korean Medicine, Sangji University) ;
  • Yu, Jun-Sang (Depart. of Sasang Constitutional Medicine, College of Korean Medicine, Sangji University)
  • 안다영 (상지대학교 한의과대학 사상체질의학교실) ;
  • 한수지 (상지대학교 한의과대학 사상체질의학교실) ;
  • 유준상 (상지대학교 한의과대학 사상체질의학교실)
  • Received : 2018.09.17
  • Accepted : 2018.09.21
  • Published : 2018.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective This study was aimed to provide the information about Cheongsimyeonja-tang by domestic papers and theses. Method 50 Domestic papers related to Cheongsimyeonja-tang were selected according to the criteria. These papers were classified and analyzed by research designs, methods and results. Result The following results were obtained in this study. 1. 19 experimental studies on the effect of Cheongsimyeonja-tang were mainly focused on anti-aging, followed by anti-allergy, anti-inflammation, improvement of immune system. And there were 4 experimental studies on the safety of Cheongsimyeonja-tang, proving safety by acute toxicity test, nephrotoxicity test, drug interaction, and test of residual ingredients after decoction. 2. 25 clinical studies on the effect of Cheongsimyeonja-tang were mainly focused on cardiovascular and cerebral vascular diseases, followed by psychiatric and otologic disorder, dermatologic and musculoskeletal diseases. Also, there were 2 studies on the effect of Cheongsimyeonja-tang for diabetes insipidus, macular degeneration, digestive disorder in terminal cancer, drug-induced hepatitis. 3. More evidenced studies on Cheongsimyeonja-tang are needed and it is recommended that psychiatric questionnaire should be used for assessing the effects of Cheongsimyeonja-tang.

Keywords

References

  1. Sang-Hyuk Kim, Yunjeong Kim, Hoseok Kim, Kyoungsik Jeong, Siwoo Lee, Research on the Usage Frequency of Sasang Constitutional Herbal Formula with Case Record Form, Korea J. Orient. Medicine Vol.17 No.2 2011.(Korean)
  2. 四象醫學. 全國韓醫科大學 四象醫學敎室. 集文堂. 1997. 157-158.
  3. Lee EH, Kim SH, Park SE, Song SJ, Seo CU, Lee YT, Kim WI, Clinical Case of Drug Induced Liver Injury Treated with Herbal Medicines in Conjunction with Western Medicines, 2007;21(1):285-290.(Korean)
  4. Yoon YG, Son DC, Song WS, A Clinical Case of Liver Injury Induced by Chungsim Yeonja-tang, Korean J. Orient. Int. Med, 2004; 25(3);539-544. (Korean)
  5. Chou LS, Ahn TW, Lee H. Studies of Chengsimyeonja- tang and Taeeumjowi-tang that get change by Wistar rat's aging. J Sasang Constitut Med. 2005;17(2):74-84. (Korean)
  6. Kim Jeong-Yeol, Kim Dong-Jun, Kim Dal-Rae, A Literature Study on Taeumin Chungsimyeonjatang on the ShinChukPan Dongyi Suse Bowon, Kim, J of Sasang Constitutional Medicine Vol. 16, No. 1, 2004; pp.12-19.(Korean)
  7. Jung Ki Kim, Anti-inflammatory effect mechanism of Quercetin, ingredient of Chungsim-Yeunja-Tang through inhibition of caspase-1 activation, Kyeong Hee University, 2009.(Korean)
  8. Kim Kyung-yo, Noh Hyun-soo, Studies on the Regulatory Effect of Cytokine Production in Taumin Patients with Cerebral Infarction by Cheongsimyeonjatang, J Sasang Constitut Med. 2000;12(2):162-170.(Korean)
  9. Seong-Eun Jin, Hye-Kyung Ha, Hyeun-Kyoo Shin, Effects of Yuldahanso-tang and Chungsimyonja-tang on Cytochrome P450 Activities, J Sasang Constitut Med 2012;24(4):84-91.(Korean) https://doi.org/10.7730/JSCM.2012.24.4.84
  10. Ok Yun-young, Ryu Do-gon, Kim Kyung-yo, Effects of Taeumin Chungsimyeunjatang on the Cerebral neurons injured by Hydrogen PeroxideJ Sasang Constitut Med 1999;11(42):251-266.(Korean)
  11. Hwang SY, Lee JH, Kim HS, Bae YC, Kim KY, Won KS. Effects of cheongsimyeonja-tang water ex- tract on the cultured primary hippocampal cell dam- agee by XO/HX. J Sasang Constitut Med. 2002: 14(3):132-145.(Korean)
  12. Han Byeung-Sam, Bae Young-Chun, Song Seung-Yun, Park Hye Sun, Lee Jae-Heung, Kim Kyung-Yo, Antioxidant effects and its mechanism of Cheongsi- myeonjatang in Sasang Constitutional Medicine, J of Sasang Constitutional Medicine Vol. 16, No. 1, 2004; 130-147.(Korean)
  13. Ohn-Soon Kim, Ye-Ji Kim, Hyeun-Kyoo Shin, Anti-atherosclerotic Effects of Herbal Formulas for Sasang Constitutional Medicine, J Sasang Constitut Med 2012;24(4):51-61.(Korean) https://doi.org/10.7730/JSCM.2012.24.4.51
  14. Ju LS, Ahn TW. Study of Cheongsimyeonja-tang that get weight, hematology, biochemistry change by Wistar rat's aging. J Daejeon Orient Med. 2004; 13(2):337-345.(Korean)
  15. Lim JP, Ahn TK. The anti-oxidative and immune-reg- ulatory effect of Chungsimyeonja-tang in aged rat. J Sasang Constitut Med. 2007;19(3):227-241.(Korean)
  16. Yoon HD, Shin OC, Shin YJ, Kim SM, Effect of Chungsimyeonjatang on Myocardiac Cell Injury in Mouse Myoblast C2C12 Cells, J. Orient. Int. Korean Med. 2007;28(2):333-345.(Korean)
  17. Han BS, Ryu DG, Lee SW, Kim KO, Effects of the Chungsimyonjatang water Extract on the Rat Myocardial Cells in Cultures, J Sasang Constitut Med. 2001;13(1):70-78.(Korean)
  18. Park JH, Kim KY, Effect of Taeumin Chungsimyoinjatang Extract on Blood Pressure and Regional Cerebral Blood Flow in Rats, J Sasang Constitut Med. 2000;12(1): 216-227.(Korean)
  19. Chang-Seob Seo, Soo-Jin Jeong, Jung-Hoon Kim, Sae-Rom Yoo, and Hyeun-Kyoo Shin, Simultaneous Analysis and Anti-obesity Effect of Taeeumin Cheongsimyeonja-tang, J Sasang Constitut Med 2013; 25(1):51-61.(Korean) https://doi.org/10.7730/JSCM.2013.25.1.51
  20. Young-Sik Yoon, Seon-Oh Keum, Se-Won Lee, Il-Hyun Kim, Ha-Il Lee, Yung-Sun Song, Effects of Cheongshimyeonja-tang on Body Weight and Serum Lipid Levels in High Fat Diet Induced Obese Mice, Herbal Formula Science 2014;22(1):123-139.(Korean) https://doi.org/10.14374/HFS.2014.22.1.123
  21. Jin-Ho Ha, Comparative Efficacy Study of Hyeong banggiwhang-tang, Cheongsimyeonja-tang and Hyangsayangyi-tang on the 5/6 Nephrectomy induced Chronic Renal Failure Rats, Daegu Haany University, 2013.(Korean)
  22. Da Young Jung, Hyekyung Ha, Ho-Young Lee, Jin-Ah Lee, Nam-Hun Lee, Jun Kyoung Lee, Dae Sun Huang, Hyeun-Kyoo Shin, Stimulation of the Immune Response by Herbal Formulas for Taeeumin, J of Sasang Constitutional Medicine Vol. 22, No. 3, 2010:141-151.(Korean)
  23. Park SC. Effects CheongSimYeonJaTang(CSYJT) on control of immune-function in highly purified mouse B cells and Mast cell. J Sasang Constitut Med. 2003; 15(2):166-179.(Korean)
  24. Jin-Ah Lee, Hyekyung Ha, Ho-Young Lee, Da Young Jung, Jun Kyoung Lee, Dae Sun Huang, Hyeun-Kyoo Shin, Anti-inflammatory Activities of Herbal Formulas for Sasang Constitutional Medicine, J of Sasang Constitutional Medicine Vol. 22, No. 4, 2010:56-64. (Korean)
  25. The Cure Effect of Cheongsimyeonjatang on Atopic Dermatitis by Regulation of Th2 Cell Differentiation and Anti-Inflammatory Mechanism, Man-Woo Kim, Dongguk university, 2006.(Korean)
  26. Suk-Woo Kim, Effect of Yuldahansotang and Chung- simyeonjatang on the Hepatic Injury, 2001, Woosuk University.(Korean)
  27. Jin-Yeul Ma, Dae-Sun Huang, Chang-Seob Seo, Si-woo Lee, Jong-Yeol Kim, Hyeun-Kyoo Shin, Acute Toxicity Study on Cheongsimyeonja-tang in Mice, J of Sasang Constitutional Medicine Vol. 22, No. 1, 2010:59-65.(Korean)
  28. Young-Jung Kim, Tae-Won Kim, Chang-Seob Seo, So-Ra Park, Hyekyung Ha, Hyeun-Kyoo Shin and Ju-Young Jung, Quatification of Flavonoid Contents in Chungsimyeonja-tang, a Multi-Herbal Decoction, and Its Protective Effect against Cisplatin-induced Nephrotoxicity, Natural Product Sciences, 2014;20(4): 251-257.(Korean)
  29. Seo CS, Huang DS, Lee JK, Ha HK, Chun JM, Um YR, Jang S, Kim JY, Lee SW, Shin HK, Concentration of Heavy Metals, Residual Pesticides and Sulfur Dioxide of before/after Decoction, 2009;21(1):237-246. (Korean)
  30. Chul-Soo Kim, Ho-Lim Song, Yong-Hyun Lee, Hyung-Joon Kim, Jung-Sun Hwang, Se-Young Lim, Sang-Min Yoo, Yoon-Chul Cho. A Case report of panic disorder patient with climacteric symptoms. THE JOURNAL OF ORIENTAL OBSTETRICS & GYNECOLOGY. 2004 Aug;17(3):190-198.(Korean)
  31. Woon-Ki Jung, Dong-Youn Han, Sang-Min Lee, Min-Jong Kim, Mee-Ran Shin, Sang-Mook Yang, Gyu-Heoun Shim, Dal-Rae Kim. A Clinical Report of Taeumin Hwa-Byeong Patient with Conversion Disorder. J. of Sasang Const. Med. 2005 Dec;17(3): 142-149.(Korean)
  32. Seung-Yun Lee, Duk-Jin Ban, Hee-Seung Lee, Kyung-Suk Han, Hyo-Sang Bae, Seong-Sik Park. A Clinical Report of the Treatment for Numbness due to Stress. J. of Sasang Const. Med. 2008 Dec;20(1): 100-108.(Korean)
  33. Kyong-Min Oh. Dong-Ho Yang. Youn-Song Cho. Bo-Kyong Kim. Clinical Report of two TGA cases. J. of Oriental Neuropsychiat. 2008 Nov;19(3):265-276. (Korean)
  34. Eun-Young Hwang, Sun-Yong Chung, Jong-Woo Kim. A Case Report of Psychogenic Tremor Patient with Head Tremor. 2010 Sep;21(3):95-103.(Korean)
  35. Jeong-ho Kim , Dong-yun Shin, Jeong-mo Song. A case study of one patient who has the sudden deafness and tinnitus caused by stress. J. of Sasang Const. Med. 2003;15(2):84-88.(Korean)
  36. Mi-Suk Lee , Min-Woo Hwang, Yun-Hee Kim. A Case Study of a Taeeumin Patient with Idiopathic Sudden Sensorineural Hearing Loss that accompanied with Tinnitus who was treated with Cheongsimyeonja-tang. J of Sasang Constitutional Medicine. 2011 Aug;23(3): 419-428.(Korean)
  37. Mi-Suk Lee, Yu-Gyeong Park, Na-Young Bae. A Case Study of a Taeeumin Patient with Meniere's Disease Treated with Cheongsimyeonja-tang. J Sasang Constitut Med. 2014 Sep;26(3):328-337.(Korean) https://doi.org/10.7730/JSCM.2014.26.3.328
  38. Jae-hyun Cho, Go-eun Bae, Hee-jeong Seo, Jin-yong Choi, So-hyun Shim, Chang-woo Han, So-yeon Kim, Jun-yong Choi, Seong-ha Park, Young-ju Yun, In Lee, Jung-nam Kwon, Si-woo Lee, Jin-woo Hong. Changes in Results of Vital Signs, Blood Tests, and Functional Tests after Taking Cheongsimyeonja-tang. J. Int. Korean Med. 2017 Dec;38(6):971-979.(Korean) https://doi.org/10.22246/jikm.2017.38.6.971
  39. Yeo-Kwang Yoon, Teh-Cheng Sun, Li-San Chou, Dae-Young Jung. A Clinical Study about Capability of hepatotoxicity asssociated with Chungsim yeonjatang. Korean J.Orient.Int. Med. 2003 Dec; 24(4):792-795. (Korean)
  40. Tae-Soo Kim, Chang-Yeon Kim, Ji-Yeun Min, Young-Gue Choi, Dae-Hee Kang. The Effects of Use of Sasang-Bang with Western Medicine on Liver and Kidney Function. J of Sasang Constitutional Medicine. 2004 Dec;16(3):70-75.(Korean)
  41. Gu-Hyeng Kang, Hyung-Soon Yong, Yong-Soo Jung, Seong-Gyu Ko, Kyoung-Hoon Park. Two case of Stroke patients assume an aspect of Cheiro-oral Syndrome. J.Orient.Int. Med. 2001 Jun;22(2):257-262. (Korean)
  42. Hyoung-soon Kim, Si-woo Lee, Hye-sun Park, Kyung-yo Kim. A Case Study about Treatment of Taeumin Patient diagnosed as Lateral medullary syn- drome(wallenberg syndrome). J. of Sasang Const. Med. 2001 Aug;13(2):182-189.(Korean)
  43. Seung-Ho Sun, Jae-eun Lee, Dong-youn Han, Seong-woo Lee, Seon-Lan Lee, Seong-Gyu Ko. The Two Case Reports of Taeumin with Central Dizziness and Cerebellar Ataxia. Korean J.Orient.Int. Med. 2004 April;25(2):335-343.(Korean)
  44. Han-Su Joung, Hyung-Soon Yung, Seung-Ho Sun, Seong-Gyu Ko. A case of cerebellum infarction treat- ment with Taeumin Chungsimtonjatang. J. of Oriental. Chr. Dis. 2003;9(1):70-77.(Korean)
  45. Hyoung soon Kim, Yung Chun Bae, Sasang Min Lee, kyung yo Kim. A study of the effects of Cheongsi- myeonjatang (CYT) on ECG in comparing before and after CYT medication: Case study of hospitalized Taeumin patients. J. of Sasang Const. Med. 2003 Dec;25(3):147-157.(Korean)
  46. Jung-chul Kim, Sung-won Oh, Chang-Hoon Song, Seul-hee Lee, Jong-jin Jeong, Seung-Ho Sun. Case Report of Chengsim Yeunja-tang (CYT) for Atrial Fibrillation with Cerebral-infarction. 2006 Sep;27(3): 751-761.(Korean)
  47. Jin-ny Lim, Eui-ju Lee, Byung-hee Koh, Il-byung Song. A Case of Treatment of a Taeumin patient with Sweaty Scrotum and Dysuria. J. of Sasang Const. Med. 2001 Dec;13(3):114-117.(Korean)
  48. Teh-Cheng Sun , Yeo-Kwang Yoon, Hae-Jin Jang, Li-San Chou, Woo-Sup Song. One Year Follow up for Severe Adult Atopic Dermatitis of 15 Patients After Sasang Constitutional Therapy. Korean J Orient.Int. Med. 2004 Sep;25(4):45-51.(Korean)
  49. Mi-Kyung Im, Jung-Mo Song. A Case Study of Taeeumin's Chronic Idiopathic Urticaria Patient. J. of Sasang Const. Med. 2008 Nov;20(3):190-198. (Korean)
  50. Teh-Cheng Sun, Hae-Jin Jang, Joong-Ki Sun. A Case Report of Chengsim Yeunja-Tang for Ankylosing Spondylitis associated with Severe Ulcerative Colitis. The Journal of Korean Oriental Internal Medicine. 2005 Sep;26(3):685-691.(Korean)
  51. Tae Hyung Lim, Hye Sun Park. Two Cases Reports of Behcet's Disease with Arthritis Treated with Oriental Medical Treatment Including Cheongsimyeonja- tang and Cheonglijagam-tang on each. J Physiol & Pathol Korean Med. Dec;28(6):643-649.(Korean) https://doi.org/10.17208/kjopp.2014.12.28.6.643
  52. Byung-Cheol Lee, Won-Man Chang, Young-Min Ahn, Se-Young Ahn, Ho-Kyung Doo. Central Diabetes Insipidus. A Case Report. J Korean Oriental Med. 2000 Jun;21(1):99-102.(Korean)
  53. Chang-Hoon Seo, Jung-Nam Kwon, Young-Kyun Kim. Senile Macular Degeneration. A Case Report. J Korean Oriental Med. 2000 Dec;21(4):260-263. (Korean)
  54. Hye-weon Kim, Woong Seo, Jeong-mo Song. A case about the patient prescribed Taeumin Chongsim Yonja Tang, suffered abdominal pain with terminal gastric cancer. J. of Sasang Const. Med. 2000 Dec; 12(2):195-200.(Korean)
  55. Byung-Ha Moon, Jae-Gwan Kim. A Case Study of hepatitis on drug metabolism Impoved with Chungsimyeunjatang. J. of Sasang Const. Med. 2003 Jun;15(1):129-131.(Korean)
  56. Jun-su Lee, Min-serh Kim, Sang-eun Park. Hematology Change about Using Korean Traditional Medicine on Inpatients. J. Int. Korean Med. 2017 Mar;38(1):64-71. (Korean) https://doi.org/10.22246/jikm.2017.38.1.64