The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Traditional Korean Medicine for Skin Toxic Side Effects from Afatinib in a Non-Small Cell Lung Cancer Patient: A Case Report

Afatinib 복약 후 발생한 비소세포성 폐암환자의 피부독성 부작용에 대한 한방치료 1례

  • Shim, So-hyun (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Seo, Hee-jeong (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Choi, Jin-yong (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Bae, Go-eun (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Seo, Hyung-bum (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Kim, So-yeon (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Han, Chang-woo (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Park, Seong-ha (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Yun, Young-ju (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Lee, In (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Kwon, Jung-nam (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Hong, Jin-woo (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Choi, Jun-yong (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University)
  • 심소현 (부산대학교 한방병원 내과학교실) ;
  • 서희정 (부산대학교 한방병원 내과학교실) ;
  • 최진용 (부산대학교 한방병원 내과학교실) ;
  • 배고은 (부산대학교 한방병원 내과학교실) ;
  • 서형범 (부산대학교 한방병원 내과학교실) ;
  • 김소연 (부산대학교 한방병원 내과학교실) ;
  • 한창우 (부산대학교 한방병원 내과학교실) ;
  • 박성하 (부산대학교 한방병원 내과학교실) ;
  • 윤영주 (부산대학교 한방병원 내과학교실) ;
  • 이인 (부산대학교 한방병원 내과학교실) ;
  • 권정남 (부산대학교 한방병원 내과학교실) ;
  • 홍진우 (부산대학교 한방병원 내과학교실) ;
  • 최준용 (부산대학교 한방병원 내과학교실)
  • Received : 2018.08.03
  • Accepted : 2018.10.26
  • Published : 2018.10.30
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Abstract

Objectives: We report a case of traditional Korean medicine (TKM) treatment for skin side effects after taking afatinib (Giotrif$^{(R)}$). Methods: A 62-year-old female who was diagnosed with non-small cell lung cancer stage 4 (T4N2M1b) and was on treatment with afatinib (29.56 mg/day for 4 months) complained of skin toxicity as a side effect. For 16 admission days, the patient was treated with acupuncture, moxibustion, and herbal medicine (oral decoction and external ointment). Results: Improvement of skin toxicity was measured by a numeric rating scale. In addition, Quality of life (QOL) was measured using EORTC Quality of Life Questionnaire, Core 30 (EORTC QLQ-C30) and EORTC Quality of Life Questionnaire, 13-item lung cancer-specific module (EORTC QLQ-LC13) Developed by the European Organization for Research and Treatment of Cancer (EORTC). Tumor size and carcinoembryonic antigen (CEA) were also examined during follow up. Conclusions: After a combined TKM treatment, skin toxicity symptoms and quality of life scales were significantly improved with no side effects. The tumor size was not changed on computed tomography during follow-up period. CEA levels were decreased.

Keywords

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