Journal of the Korean Medical Association (대한의사협회지)

Korean Medical Association (대한의사협회)
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Etiology and treatment of central precocious puberty

중추성 사춘기 조숙증의 원인 및 치료

  • Kim, Se Young (Division of Endocrinology and Metabolism, Department of Pediatrics, Bundang Jesaeng General Hospital, Daejin Medical Center)
  • 김세영 (분당제생병원 소아청소년과 내분비분과)
  • Received : 2018.08.23
  • Accepted : 2018.08.24
  • Published : 2018.10.20
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Abstract

The timing of pubertal onset is occurring at younger ages. This phenomenon is associated with many environmental factors such as sufficient nutrition, stress, many kinds of endocrine-disrupting chemicals, and genetic background. The loss of transcriptional repression induces kisspeptin release, resulting in pulsatile gonadotropin-releasing hormone secretion, which trigger pubertal onset. According to many reports, gonadotropin-releasing hormone agonists therapy for patients with rapidly progressive central precocious puberty is effective for improving final adult height. However, those results were obtained from the treatment of relatively young patients at earlier stages of puberty. A large cohort study investigating the environmental causes of precocious puberty as well as genetic factors is needed.

Keywords

References

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