Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Immunomodulatory Effects by Bifidobacterium longum KACC 91563 in Mouse Splenocytes and Macrophages

  • Choi, Mijoo (Department of Food and Nutrition, Kyungnam University) ;
  • Lee, Yunjung (Department of Food and Nutrition, Kyungnam University) ;
  • Lee, Na-Kyoung (Department of Food Science and Biotechnology of Animal Resources, Konkuk University) ;
  • Bae, Chun Ho (Aram Co., Ltd.) ;
  • Park, Dae Chul (Aram Co., Ltd.) ;
  • Paik, Hyun-Dong (Department of Food Science and Biotechnology of Animal Resources, Konkuk University) ;
  • Park, Eunju (Department of Food and Nutrition, Kyungnam University)
  • Received : 2018.12.03
  • Accepted : 2019.09.05
  • Published : 2019.11.28
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Abstract

The present study evaluates the immunomodulatory effect of Bifidobacterium longum KACC 91563 in murine primary splenocytes and macrophages. B. longum KACC 91563 regulated T- and B-cell proliferation and inhibited the Th1 (IL-2, IFN-γ)/Th2 (IL-4, IL-10) cytokine imbalance and immune cytokine production. Moreover, immunoglobulin E (IgE) levels were significantly lower after treatment with B. longum KACC 91563. These findings suggest that B. longum KACC 91563 could modulate the systemic immune system toward both IgE production and regulation of the Th1/Th2 balance.

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