Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Potential uses of Aristotelia chilensis extracts as novel cosmetic materials

마키베리 추출물의 화장품 신규 원료로서의 가능성

  • Kim, Mijung (Department of Health and Cosmetics, Dongduk Women's University) ;
  • Park, Seyeon (Department of Applied Chemistry, Dongduk Women's University)
  • Received : 2019.07.23
  • Accepted : 2019.10.02
  • Published : 2019.12.31
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Abstract

The present study aims to investigate the potential applications of Aristotelia chilensis (A. chilensis) extracts as novel cosmetic materials. The total extracts of A. chilensis were partitioned into chloroform (CHCl3), ethyl acetate (EtOAc), and distilled water (DW) fractions. A. chilensis extracts exhibited no cytotoxicity toward HaCaT human keratinocyte and B16F10 mouse melanoma cell lines. CHCl3, EtOAc, and DW extracts reduced oxidative stress, and EtOAc extract was superior to glutathione, a natural human antioxidant positive control. The extracts of A. chilensis reduced melanin synthesis in cells treated with α-melanocyte-stimulating hormone. The extracts of A. chilensis exhibited antibacterial effects toward Staphylococcus aureus (S. aureus), Staphylococcus epidermidis (S. epidermidis), and Pseudomonas aeruginosa (P. aeruginosa). In particular, the EtOAc extract was effective in terms of antibacterial activity against S. aureus. In the present study, we identified several potential applications of A. chilensis extracts in terms of novel antioxidant and whitening cosmetic materials as well as antibacterial preservatives.

본 연구는 마키베리 추출물이 화장품의 신규 원료로서 가능성이 있는지를 타진하는 것을 목적으로 진행되었다. 마키베리 조추출물을 클로로포름층과 에틸아세테이트층, 증류수층으로 분리하였다. 먼저, 마키베리 추출물들의 독성 여부를 피부각질세포주인 HaCaT 세포와 색소형성세포주인 B16F10 세포를 통해 확인하였다. 항산화 효과 실험에서 클로로포름층, 에틸아세테이트층 그리고 증류수층 추출물들은 모두 산화적 스트레스를 줄이는 효과를 보였고 그 중에 에틸아세테이트층 추출물은 양성대조군인 글루타치온에 비해서도 우수한 결과를 나타내었다. 마키베리 추출물들은 α-MSH에 의한 멜라닌 합성도 저해하였다. 또한, 마키베리 추출물들은 그람양성균인 황색포도상구균과 표피포도상구균, 그람음성균인 녹농균에 대해서도 항균 효과를 보였다. 특히, 에틸아세테이트층 추출물은 황색포도상구균에 대해서 뛰어난 항균 효과를 보였다. 본 연구를 통해서 마키베리 추출물들이 화장품의 항산화나 미백 기능성 원료로서뿐만 아니라 화장품의 천연방부제 원료로서도 잠재적인 가능성이 있음을 확인할 수 있었다.

Keywords

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