Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Cytotoxic Constituents from the Roots of Asarum sieboldii in Human Breast Cancer Cells

  • Kim, Eunae (College of Pharmacy, Chosun University) ;
  • Kim, Hyun Jung (College of Pharmacy, Mokpo National University) ;
  • Oh, Ha-Na (College of Pharmacy, Mokpo National University) ;
  • Kwak, Ah-Won (College of Pharmacy, Mokpo National University) ;
  • Kim, Su-Nam (KIST Gangneung Institute) ;
  • Kang, Bok Yun (College of Pharmacy, Chonnam National University) ;
  • Cho, Seung-Sik (College of Pharmacy, Mokpo National University) ;
  • Shim, Jung-Hyun (College of Pharmacy, Mokpo National University) ;
  • Yoon, Goo (College of Pharmacy, Mokpo National University)
  • Received : 2018.07.26
  • Accepted : 2018.12.01
  • Published : 2019.03.31
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Abstract

Bioassay-guided fractionation of the roots of Asarum sieboldii led to the isolation of the six compounds methylkakuol (1), sesamin (2), asarinin (3), xanthoxylol (4), and (2E,4E,8Z,10E/Z)-N-(2-methylpropyl) dodeca-2,4,8,10-tetraenamide (5/6). Among the isolates, xanthoxylol (4) exhibited significant cytotoxicity against human breast cancer cells MCF-7 and MDA-MB-231 in vitro with $IC_{50}$ values of 9.15 and $13.95{\mu}M$, respectively.

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References

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