Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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Formulation of the Scope and Key Questions of the Guideline Recommendations for Immunosuppressive Treatment in Kidney Transplantation

신장이식 면역억제요법 가이드라인 개발을 위한 권고안 적용 범위 및 핵심질문 선정

  • Huh, Seungyeon (College of Pharmacy & Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Han, Nayoung (College of Pharmacy & Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Sohn, Minji (College of Pharmacy & Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Ryu, Junghwa (Transplantation Center, Seoul National University Hospital) ;
  • Yang, Jaeseok (Transplantation Center, Seoul National University Hospital) ;
  • Oh, Jung Mi (College of Pharmacy & Research Institute of Pharmaceutical Science, Seoul National University)
  • 허승연 (서울대학교 약학대학) ;
  • 한나영 (서울대학교 약학대학) ;
  • 손민지 (서울대학교 약학대학) ;
  • 류정화 (서울대학교병원 장기이식센터) ;
  • 양재석 (서울대학교병원 장기이식센터) ;
  • 오정미 (서울대학교 약학대학)
  • Received : 2018.12.19
  • Accepted : 2019.03.06
  • Published : 2019.03.31
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Abstract

Background: Although a growing number of guidelines and clinical researches are available for immunosuppressive treatment of post-transplantation, there is no clinical practice guideline for the care of kidney transplant recipients in Korea. Selection of a researchable question is the most important step in conducting qualified guideline development. Thus, we aimed to formulate key questions for Korean guideline to aid clinical decision-making for immunosuppressive treatment. Methods: Based on previous published guidelines review, a first survey was constructed with 29 questions in the range of immunosuppressive treatments. The experts were asked to rate the clinical importance of the question using a 5-point Likert scale. The questions reached 60% or more from the first survey and additional new questions were included in the second survey. In analyzing the responses to items rated on the 9-point scale, consensus agreement on each question was defined as 75% or more of experts rating 7 to 9. Results: In the first survey, 50 experts were included. Among the 29 questions, 27 were derived to get 60% or more importance and 3 new questions were additionally identified. Through the second survey, 9 questions were selected that experts reached consensus on 75% and over of the options. Finally, we developed key questions using PICO (patient, intervention, comparison, and outcome) methodology. Conclusion: The experts reached a high level of consensus on many of key questions in the survey. Final key questions provide direction for developing clinical practice guideline in the immunosuppressive treatment of transplantation.

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References

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