Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes

보골탕이 Monosodium Iodoacetate 유도 골관절염과 Interleukin-1β 유도 연골세포에 미치는 보호 효과

  • Sung, Jin Wook (Department of Korean Rehabilitation Medicine, College of Korean Medicine, Dong-eui University) ;
  • Lee, Hai Woong (Department of Preventive Medicine, College of Korean Medicine, Dong-eui University) ;
  • Kang, Kyung Hwa (Department of Physiology, College of Korean Medicine, Dong-eui University) ;
  • Kim, Kyoung Min (Department of Oriental Internal Medicine, College of Korean Medicine, Dong-eui University) ;
  • Cho, Sung Woo (Department of Korean Rehabilitation Medicine, College of Korean Medicine, Dong-eui University)
  • 성진욱 (동의대학교 한의과대학 한방재활의학과교실) ;
  • 이해웅 (동의대학교 한의과대학 예방의학교실) ;
  • 강경화 (동의대학교 한의과대학 생리학교실) ;
  • 김경민 (동의대학교 한의과대학 한방내과학교실) ;
  • 조성우 (동의대학교 한의과대학 한방재활의학과교실)
  • Received : 2019.03.14
  • Accepted : 2019.04.17
  • Published : 2019.04.30
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Abstract

Objectives Bogol-tang has clinically been used to protect joint cartilage and to treat osteoarthritis. Our objective was to study the protective effect of Bogol-tang extract (BGT) in functional impairment, behavioral disorders, cartilage loss and pathological changes in a monoiodoacetate (MIA)-induced murine osteoarthritis (OA) model and interleukin (IL)-$1{\beta}$ -treated primary rat chondrocytes. Methods Mouse knee joints were injected with MIA, a chemical that inhibits glycolysis and causes joint inflammation and matrix loss. MIA-OA induced mice orally administered BGT or acetaminophen (AAP) for 18 days by daily. Primary rat chondrocytes were pretreated with BGT or dexamethasone (DEX) and followed by co-incubation with IL-$1{\beta}$ (10 ng/mL). Results In MIA-OA mice model, BGT led to delayed response on hot plate analysis, and suppressed the cartilage loss and damages in joint tissues. BGT suppressed the elevated levels of inflammatory mediators, nitrite and $PGE_2$, the gene expression of matrix degrading enzymes, and extracellular-signal-regulated kinases 1/2 and c-JunN-terminal kinase phosphorylation in IL-$1{\beta}$-treated primary rat chondrocytes. Conclusions Our results suggest that BGT improve the knee joint function and delay the cartilage damages by anti-nociceptive, anti-inflammatory and ant-catabolic effects, which indicate BGT could be a potential candidate for osteoarthritis treatment.

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References

  1. The Society of Korean Medicine Rehabilitation. Korean Rehabilitation Medicine. 4th ed. Paju:Koonja Publishing. 2015:115.
  2. Blagojevic M, Jinks C, Jeffery A, Jordan KP. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis and Cartilage/OARS, Osteoarthritis Research Society. 2010;18(1): 24-33. https://doi.org/10.1016/j.joca.2009.08.010
  3. Hamilton JL, Nagao M, Levine BR, Chen D, Olsen BR, Im HJ. Targeting VEGF and its receptors for the treatment of osteoarthritis and associated pain. Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research. 2016; 31(5):911-24. https://doi.org/10.1002/jbmr.2828
  4. Lories RJ, Luyten FP. The bone-cartilage unit in osteoarthritis. Nature reviews Rheumatology. 2011;7(1):43-9. https://doi.org/10.1038/nrrheum.2010.197
  5. Valdes AM, Spector TD. Genetic epidemiology of hip and knee osteoarthritis. Nature reviews Rheumatology. 2011;7(1):23-32. https://doi.org/10.1038/nrrheum.2010.191
  6. Berenbaum F. New horizons and perspectives in the treatment of osteoarthritis. Arthritis Research and Therapy. 2008;10 Suppl 2:S1. https://doi.org/10.1186/ar2462
  7. Ringdahl E, Pandit S. Treatment of knee osteoarthritis. American Family Physician. 2011;83(11):1287-92.
  8. Corbett MS, Rice SJ, Madurasinghe V, Slack R, Fayter DA, Harden M, Sutton AJ, Macpherson H, Woolacott NF. Acupuncture and other physical treatments for the relief of pain due to osteoarthritis of the knee: network meta-analysis. Osteoarthritis and cartilage/OARS, Osteoarthritis Research Society. 2013;21(9):1290-8. https://doi.org/10.1016/j.joca.2013.05.007
  9. Magden ER, Haller RL, Thiele EJ, Buchl SJ, Lambeth SP, Schapiro SJ. Acupuncture as an adjunct therapy for osteoarthritis in chimpanzees (Pan troglodytes). Journal of the American Association for Laboratory Animal Science. 2013;52(4):475-80.
  10. Ren X, Yao C, Wu F, Li Z, Xing J, Zhang H. Effectiveness of moxibustion treatment in quality of life in patients with knee osteoarthritis: a randomized, double-blinded, placebo-controlled trial. Evid Based Complement Alternat Med. 2015;2015:569523.
  11. Kim EJ, Jang MK, Yoon EH, Jung CY, Nam DW, Lee SD, Kim KS. Efficacy of pharmacopuncture using root bark of Ulmus davidiana Planch in patients with knee osteoarthritis: a double-blind randomized controlled trial. Journal of Acupuncture and Meridian Studies. 2010;3(1):16-23. https://doi.org/10.1016/S2005-2901(10)60003-9
  12. Sharma L. Osteoarthritis year in review 2015: clinical. Osteoarthritis and cartilage/OARS, Osteoarthritis Research Society. 2016;24(1):36-48. https://doi.org/10.1016/j.joca.2015.07.026
  13. Park JH, Jeong SH. Review of the studies on the influence of experimental arthritis model of herbal medicine extract. J Korean Med Rehabil. 2018;18(3):39-53. https://doi.org/10.18325/jkmr.2018.28.3.39
  14. Dumond H, Presle N, Pottie P, Pacquelet S, Terlain B, Netter P, Gepstein A, Livne E, Jouzeau JY. Site specific changes in gene expression and cartilage metabolism during early experimental osteoarthritis. Osteoarthritis and Cartilage. 2004;12(4):284-95. https://doi.org/10.1016/j.joca.2003.11.008
  15. Pitcher T, Sousa-Valente J, Malcangio M. The monoiodoacetate model of osteoarthritis pain in the mouse. J Vis Exp. 2016;(111). doi: 10.3791/53746.
  16. Focht BC, Ewing V, Gauvin L, Rejeski WJ. The unique and transient impact of acute exercise on pain perception in older, overweight, or obese adults with knee osteoarthritis. Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine. 2002;24(3):201-10. https://doi.org/10.1207/S15324796ABM2403_05
  17. Inglis JJ, McNamee KE, Chia SL, Essex D, Feldmann M, Williams RO, Hunt SP, Vincent T. Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system. Arthritis and Rheumatism. 2008;58(10):3110-9. https://doi.org/10.1002/art.23870
  18. Luyten FP, Lories RJ, Verschueren P, de Vlam K, Westhovens R. Contemporary concepts of inflammation, damage and repair in rheumatic diseases. Best Practice and Research Clinical Rheumatology. 2006;20(5):829-48. https://doi.org/10.1016/j.berh.2006.06.009