Journal of Animal Science and Technology

Korean Society of Animal Sciences and Technology (한국축산학회)
권호 표지
DOI QR코드

DOI QR Code

Intravenous administration of L-tryptophan stimulates gastrointestinal hormones and melatonin secretions: study on beef cattle

  • Lee, Sang-Bum (Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University) ;
  • Lee, Kyung-Won (Life Science Technology, Inc.) ;
  • Wang, Tao (Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural University) ;
  • Lee, Jae-Sung (Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University) ;
  • Jung, U-Suk (Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University) ;
  • Nejad, Jalil Ghassemi (Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University) ;
  • Oh, Young-Kyoon (Department of Nutrition and Physiology, National Institute of Animal Science, RDA) ;
  • Baek, Youl-Chang (Department of Nutrition and Physiology, National Institute of Animal Science, RDA) ;
  • Kim, Kyoung Hoon (Graduate School of International Agricultural Technology, Pyeongchang Campus, Seoul National University) ;
  • Lee, Hong-Gu (Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University)
  • Received : 2019.03.29
  • Accepted : 2019.06.10
  • Published : 2019.07.31
Download PDF
⟨ Previous Next ⟩

Abstract

This study aimed to determine the effective dose of intravenous administration of L-tryptophan (L-T) on gastrointestinal hormones (GIH) secretions and melatonin using Hanwoo cattle. Three steers ($362{\pm}23kg$) fitted with indwelling jugular vein catheters were assigned in a $3{\times}3$ Latin square design. Treatments were intravenous administration of saline (control), 28.9 mg L-T/kg body weight (BW; low) and 57.8 mg L-T/kg BW (high) L-T for 1 day with 7 days of adaptation. Samples were collected after adaptation period at -60, 0, 30, 60, 90, 120, 150, 180, 240, and 300 min of sampling day. The levels of serum cholecystokinin (CCK) and secretin were higher (p < 0.05) in the high L-T group than those in the other groups. Serum Melatonin (MEL) levels were increased upon L-T administration (p < 0.05) in the high L-T group. Taken together, the effective dose of L-T administration was defined at 57.8 mg L-T/kg BW in order to stimulate increase of GIH and MEL.

Keywords

References

  1. Guzik AC, Matthews JO, Kerr BJ, Bidner TD, Southern LL. Dietary tryptophan effects on plasma and salivary cortisol and meat quality in pigs. J Anim Sci. 2006;84:2251-9. https://doi.org/10.2527/jas.2005-292
  2. Lee SB, Choi CW, Jin YC, Wang T, Lee KH, Ku MB, et al. Effect of oral administration of intact casein on gastrointestinal hormone secretion and pancreatic alpha-amylase activity in Korean Native Steer. Asian-Australas J Anim Sci. 2013;26:654-60. https://doi.org/10.5713/ajas.2012.12510
  3. Kasuya E, Yayou K, Hashizume T, Kitagawa S, Sutoh M. A possible role of central serotonin in L-tryptophan-induced GH secretion in cattle. Anim Sci J. 2010;81:345-51. https://doi.org/10.1111/j.1740-0929.2010.00747.x
  4. Seeve B. Physiological roles of tryptophan in pig nutrition. In: Huether G, Kochen W, Simat TJ, Steinhart H, editors. Tryptophan, serotonin, and melatonin: basic aspects and applications. New York, NY, USA: Academic/Plenum; 1999. p.729-41.
  5. Ma H, Cheng J, Zhu X, Jia Z. Effects of rumen-protected tryptophan on performance, nutrient utilization and plasma tryptophan in cashmere goats. Afr J Biotechnol. 2011;10:5806-11.
  6. Alkozi HA, Sanchez Montero JM, Doadrio AL, Pintor J. Docking studies for melatonin receptors. Expert Optin Drug Discov. 2018;13:241-8. https://doi.org/10.1080/17460441.2018.1419184
  7. Bello AU, Idrus Z, Meng GY, Award EA, Farjam AS. Gut microbiota and transportation stress response affected by tryptophan supplementation in broiler chickens. Ital J Anim Sci. 2018;17:107-13. https://doi.org/10.1080/1828051X.2017.1340814
  8. Liang H, Dai Z, Liu N, Ji Y, Chen J, Zhang Y, et al. Dietary L-tryptophan modulates the structural and functional composition of the intestinal microbiome in weaned piglets. Front Microbiol. 2018;9:1-12. https://doi.org/10.3389/fmicb.2018.00001
  9. Leja-Szpak A, Jaworek J, Nawrot-Porabka K, Palonek M, Mitis-Musiol M, Dembinski A, et al. Modulation of pancreatic enzyme secretion by melatonin and its precursor; L-tryptophan. Role of CCK and afferent nerves. J Physiol Pharmacol. 2004;55 Suppl 2:33-46.
  10. Montgomery GW, Flux DS, Greenway RM. Tryptophan deficiency in pigs: changes in food intake and plasma levels of glucose, amino acids, insulin and growth hormone. Horm Metab Res. 1980;12:304-9. https://doi.org/10.1055/s-2007-996276
  11. Henry Y, Seve B, Colleaux Y, Ganier P, Saligaut C, Jego P. Interactive effects of dietary levels of tryptophan and protein on voluntary feed intake and growth performance in pigs, in relation to plasma free amino acids and hypothalamic serotonin. J Anim Sci. 1992;70:1873-87. https://doi.org/10.2527/1992.7061873x
  12. Charney DS, Heninger GR, Reinhard JF Jr, Strenberg DE, Hafstead KM. The effect of intravenous L-tryptophan on prolactin and growth hormone and mood in healthy subjects. Psychopharmacol. 1982;77:217-22. https://doi.org/10.1007/BF00464569
  13. Jaworek J. Ghrelin and melatonin in the regulation of pancreatic exocrine secretion and maintaining of integrity. J Physiol Pharmacol. 2006;57 Suppl 5:83-96.
  14. Lee KH, Wang T, JinYC, Lee SB, Oh JJ, Hwang JH, et al. Identification of proteins involved in the pancreatic exocrine by exogenous ghrelin administration in Sprague-Dawley rats. J Anim Sci Technol. 2014;56:6. https://doi.org/10.1186/2055-0391-56-6
  15. National Institute of Animal Science [NIAS]. Korean feeding standard for Hanwoo. Suwon, Korea: Rural Development Administration; 2007. p.158.
  16. Association of Official Analytical Chemists [AOAC]. Official methods of analysis of AOAC. 13th ed. Washington, DC, USA: AOAC; 1980.
  17. National Academies of Sciences, Engineering, and Medicine. Nutrient requiremnets of beef cattle. 8th ed. Washington, DC, USA: The National Academies Press; 2016. p.406.
  18. Jaworek J, Nawrot K, Konturek SJ, Leja-Szpak A, Thor P, Pawlik WW. Melatonin and its precursor, L-tryptophan: influence on pancreatic amylase secretion in vivo and in vitro. J Pineal Res. 2004;36:155-64. https://doi.org/10.1046/j.1600-079X.2003.00110.x
  19. Zhang H, Yin J, Li D, Zhou X, Li X. Tryptophan enhances ghrelin expression and secretion associated with increased food intake and weight gain in weanling pigs. Domest Anim Endocrinol. 2007;33:47-61. https://doi.org/10.1016/j.domaniend.2006.04.005
  20. Arnold MA, Fernstrom JD. L-Tryptophan injection enhances pulsatile growth hormone secretion in the rat. Endocrinol. 1981;108:331-5. https://doi.org/10.1210/endo-108-1-331
  21. Brunetti L, Recinella L, Orlando G, Michelotto B, Di Nisio C, Vacca M. Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus. Eur J Pharmacol. 2002;454:189-92. https://doi.org/10.1016/S0014-2999(02)02552-9
  22. Ipharraguerre IR, Clark JH. Impacts of the source and amount of crude protein on the intestinal supply of nitrogen fractions and performance of dairy cows. J Dairy Sci. 2005;88 Suppl 1:E22-37. https://doi.org/10.3168/jds.S0022-0302(05)73134-9
  23. Go VL, Hofmann AF, Summerskill WH. Pancreozymin bioassay in man based on pancreatic enzyme secretion: potency of specific amino acids and other digestive products. J Clin Invest. 1970;49:1558-64. https://doi.org/10.1172/JCI106373
  24. Hashimoto N, Hara H. Dietary branched-chain amino acids suppress the expression of pancreatic amylase mRNA in rats. Biosci Biotechnol Biochem. 2004;68:1067-72. https://doi.org/10.1271/bbb.68.1067

Cited by

  1. Administration of encapsulated L-tryptophan improves duodenal starch digestion and increases gastrointestinal hormones secretions in beef cattle vol.33, pp.1, 2020, https://doi.org/10.5713/ajas.19.0498
  2. Supplementing with L-Tryptophan Increases Medium Protein and Alters Expression of Genes and Proteins Involved in Milk Protein Synthesis and Energy Metabolism in Bovine Mammary Cells vol.22, pp.5, 2021, https://doi.org/10.3390/ijms22052751
  3. Dietary supplementation of acetate-conjugated tryptophan alters feed intake, milk yield and composition, blood profile, physiological variables, and heat shock protein gene expression in heat-stressed vol.98, 2019, https://doi.org/10.1016/j.jtherbio.2021.102949
  4. Effects of Dietary Supplementation of Acetate and L-Tryptophan Conjugated Bypass Amino Acid on Productivity of Pre- and Post-Partum Dairy Cows and Their Offspring vol.11, pp.6, 2019, https://doi.org/10.3390/ani11061726
  5. Effects of Duodenal 5-Hydroxytryptophan Perfusion on Melatonin Synthesis in GI Tract of Sheep vol.26, pp.17, 2019, https://doi.org/10.3390/molecules26175275
  6. Effect of Heat Stress on Bovine Mammary Cellular Metabolites and Gene Transcription Related to Amino Acid Metabolism, Amino Acid Transportation and Mammalian Target of Rapamycin (mTOR) Signaling vol.11, pp.11, 2021, https://doi.org/10.3390/ani11113153