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Study on the VEGF Gene Expression and the Role of PMSG Hormone in the Development of Endometrial Cancer in Mice

  • Kim, Sang-Hwan (Institute of Genetic Engineering, Hankyong National University) ;
  • Jung, Na-Hyeon (Major in the Animal Biotechnology, Graduate School of Future Convergence Technology, Hankyong National University) ;
  • Oh, Min-Gee (Department of Animal Life Science, Hankyong National University) ;
  • Yoon, Jong-Taek (Institute of Genetic Engineering, Hankyong National University)
  • Received : 2020.03.07
  • Accepted : 2020.03.16
  • Published : 2020.03.31

Abstract

In this study, we investigated whether infusion of colorectal cancer cell line and PMSG could increase endometrial cancer. As a result, our study confirmed that the injection of colorectal cancer can cause inflammation and cancer in the uterus and increase the VEGF gene in the uterus. The study also found that endometrial cancer was associated with PMSG.

Keywords

References

  1. Arnold CN, Goel A, Blum HE, Boland CR. 2005. Molecular pathogenesis of colorectal cancer: implications for molecular diagnosis. Cancer 104:2035-2047. https://doi.org/10.1002/cncr.21462
  2. Biswas D and Hyun SH. 2007. Effect of vascular endothelial growth factor on porcine in vitro maturation. J. Embryo Transf. 22:213-218.
  3. Cheung LW, Hennessy BT, Li J, Yu S, Myers AP, Djordjevic B, Lu Y, Stemke-Hale K, Dyer MD, Zhang F, Ju Z, Cantley LC, Scherer SE, Liang H, Lu KH, Broaddus RR, Mills GB. 2011. High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov. 1:170-185. https://doi.org/10.1158/2159-8290.CD-11-0039
  4. Contreras CM, Akbay EA, Gallardo TD, Haynie JM, Sharma S, Tagao O, Bardeesy N, Takahashi M, Settleman J, Wong KK, Castrillon DH. 2010. Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis. Model. Mech. 3:181-193. https://doi.org/10.1242/dmm.004440
  5. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. 2015. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer 136:E359-E386. https://doi.org/10.1002/ijc.29210
  6. Ferrara N and Davis-Smyth T. 1997. The biology of vascular endothelial growth factor. Endocr. Rev. 18:4-25. https://doi.org/10.1210/er.18.1.4
  7. Glaab WE, Risinger JI, Umar A, Kunkel TA, Barrett JC, Tindall KR. 1998. Characterization of distinct human endometrial carcinoma cell lines deficient in mismatch repair that originated from a single tumor. J. Biol. Chem. 273:26662-26669. https://doi.org/10.1074/jbc.273.41.26662
  8. Jeong W and Song G. 2014. EGF, IGF-I, VEGF and CSF2: effects on trophectoderm of porcine conceptus. Reprod. Dev. Biol. 38:21-34. https://doi.org/10.12749/RDB.2014.38.1.21
  9. Jin DI and Yang MH. 1997. Effects of superovulation induction on embryo quantity and quality in rat. Korean J. Embryo Transf. 12:127-132.
  10. Kim DS, Kim SH, Yoon JT. 2011. Expression of PAPP-A and $20{\alpha}$-HSD in the bovine corpus luteum during early pregnancy. J. Embryo Transf. 26:57-63.
  11. Kim KY and Choi KC. 2009. Gonadotropin-releasing hormone and its receptor as a therapeutic concept in the progression of epithelial ovarian cancer. J. Embryo Transf. 24:1-14.
  12. Kim SH, Kim KL, Lee JH, Shin DH, Jung NH, Lee HJ, Yoon JT. 2018. Detection of matrix metalloproteinases patterns in bovine luteum cell during pregnancy. J. Embryo Transf. 33:61-68. https://doi.org/10.12750/JET.2018.33.2.61
  13. Lee JY and Song G. 2013. The laying hen: an animal model for human ovarian cancer. Reprod. Dev. Biol. 37:41-49. https://doi.org/10.12749/RDB.2013.37.1.41
  14. Lee M, Ahn JI, Kwun H, Ko DW, Ahn J, Lim JM. 2018. Possible improvement of oocyte supply by the use of aged mice and different gonadotrophins. J. Embryo Transf. 33:69-73. https://doi.org/10.12750/JET.2018.33.2.69
  15. Lin Q, Wang Y, Chen D, Sheng X, Liu J, Xiong H. 2017. Cisplatin regulates cell autophagy in endometrial cancer cells via the PI3K/AKT/mTOR signalling pathway. Oncol. Lett. 13:3567-3571. https://doi.org/10.3892/ol.2017.5894
  16. Lionti S, Reggiani Bonetti L, Bettelli S, Spallanzani A, Gelsomino F, Barresi V. 2018. Histopathological variables in liver metastases of patients with stage IV colorectal cancer: potential prognostic relevance of poorly differentiated clusters. Hum. Pathol. 78:115-124. https://doi.org/10.1016/j.humpath.2018.04.019
  17. McConechy MK, Ding J, Cheang MC, Wiegand K, Senz J, Tone A, Yang W, Prentice L, Tse K, Zeng T, McDonald H, Schmidt AP, Mutch DG, McAlpine JN, Hirst M, Shah SP, Lee CH, Goodfellow PJ, Gilks CB, Huntsman DG. 2012. Use of mutation profiles to refine the classification of endometrial carcinomas. J. Pathol. 228:20-30. https://doi.org/10.1002/path.4056
  18. Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E. 2016. Endometrial cancer. Lancet 387:1094-1108. https://doi.org/10.1016/S0140-6736(15)00130-0
  19. Otrock ZK, Makarem JA, Shamseddine AI. 2007. Vascular endothelial growth factor family of ligands and receptors: review. Blood Cells Mol. Dis. 38:258-268. https://doi.org/10.1016/j.bcmd.2006.12.003
  20. Park HY and Kang MJ. 2011. Regulation of long-chain Acyl-CoA synthetase 4 expression with progesterone and estradiol-$17{\beta}$. Reprod. Dev. Biol. 35:215-219.
  21. Roskoski R Jr. 2007. Vascular endothelial growth factor (VEGF) signaling in tumor progression. Crit. Rev. Oncol. Hematol. 62:179-213. https://doi.org/10.1016/j.critrevonc.2007.01.006
  22. Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A, Jemal A. 2017. Colorectal cancer statistics, 2017. CA Cancer J. Clin. 67:177-193. https://doi.org/10.3322/caac.21395
  23. Siegel RL, Miller KD, Jemal A. 2015. Cancer statistics, 2015. CA Cancer J. Clin. 65:5-29. https://doi.org/10.3322/caac.21254
  24. Sillars-Hardebol AH, Carvalho B, de Wit M, Postma C, Delis-van Diemen PM, Mongera S, Ylstra B, van de Wiel MA, Meijer GA, Fijneman RJ. 2010. Identification of key genes for carcinogenic pathways associated with colorectal adenomato-carcinoma progression. Tumour Biol. 31:89-96. https://doi.org/10.1007/s13277-009-0012-1
  25. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. 2015. Global cancer statistics, 2012. CA Cancer J. Clin. 65:87-108. https://doi.org/10.3322/caac.21262
  26. Weigelt B, Warne PH, Lambros MB, Reis-Filho JS, Downward J. 2013. PI3K pathway dependencies in endometrioid endometrial cancer cell lines. Clin. Cancer Res. 19:3533-3544. https://doi.org/10.1158/1078-0432.CCR-12-3815
  27. Yun SK, Yu WJ, Yun YW. 1998. Differential effects of gonadotropin-releasing hormone (GnRH) agonist on ovarian function in early and late follicular phase of pregnant mare serum gonadotropin (PMS G) -pretreated immature rats. Korean J. Embryo Transf. 13:261-275.